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Buist, H.E. (author), Devito, S. (author), Goldbohm, R.A. (author), Stierum, R.H. (author), Venhorst, J. (author), Kroese, E.D. (author)Carbon capture and storage (CCS) technologies are considered vital and economic elements for achieving global CO2 reduction targets, and is currently introduced worldwide (for more information on CCS, consult for example the websites of the International Energy Agency (http://www.iea.org/topics/ccs/) and the Global CCS Institute (http://www...article 2015
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Chen, Q. (author), Balaji, S.P. (author), Ramdin, M. (author), Gutiérrez-Sevillano, J.J. (author), Bardow, A. (author), Goetheer, E.L.V. (author), Vlugt, T.J.H. (author)CO2 readily reacts in aqueous amine solutions. The properties of free CO2 in amine solutions are therefore difficult to obtain directly and are often predicted from the nonreacting molecule N2O due to the similarities in mass and structure. This often-used empirical "CO2/N2O analogy" is verified in this work using molecular simulation....article 2014
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TNO Defensie en Veiligheid (author), Tuin, A.W. (author), Mol, M.A.E. (author), van den Berg, R.M. (author), Fidder, A. (author), van der Marel, G.A. (author), Overkleeft, H.S. (author), Noort, D. (author)Elucidation of noncholinesterase protein targets of organophosphates, and nerve agents in particular, may reveal additional mechanisms for their high toxicity as well as clues for novel therapeutic approaches toward intoxications with these agents. Within this framework, we here describe the synthesis of the activity-based probe 3, which...article 2009
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Damsten, M.C. (author), Commandeur, J.N.M. (author), Fidder, A. (author), Hulst, A.G. (author), Touw, D. (author), Noort, D. (author), Vermeulen, N.P.E. (author), TNO Defensie en Veiligheid (author)Covalent binding of reactive electrophilic intermediates to proteins is considered to play an important role in the processes leading to adverse drug reactions and idiosyncratic drug reactions. Consequently, both for the discovery and the development of new drugs, there is a great interest in sensitive methodologies that enable the detection of...article 2007
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Usta, M. (author), Wortelboer, H.M. (author), Vervoort, J. (author), Boersma, M.G. (author), Rietjens, I.M.C.M. (author), van Bladeren, P.J. (author), Cnubben, N.H.P. (author), TNO Kwaliteit van Leven (author)Curcumin, an α,β-unsaturated carbonyl compound, reacts with glutathione, leading to the formation of two monoglutathionyl curcumin conjugates. In the present study, the structures of both glutathione conjugates of curcumin were identified by LC-MS and one- and two-dimensional 1H NMR analysis, and their formation in incubations with human...article 2007
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van der Veen, M. (author), Norde, W. (author), Stuart, M.C. (author)The influence of succinylation on lysozyme is studied using circular dichroism, fluorescence spectroscopy, and differential scanning calorimetry. The spectroscopic data reveal that at room temperature the structures of succinylated lysozyme and native lysozyme are similar. However, the calorimetric results show that the thermal stability of...article 2005
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TNO Voeding (author), van der Woude, H. (author), Alink, G.M. (author), van Rossum, B.E.J. (author), Walle, K. (author), van Steeg, H. (author), Walle, T. (author), Rietjens, I.M.C.M. (author)This study investigates the role of cellular tyrosinase and/or peroxidase-like oxidative enzyme activity in the covalent binding of quercetin to glutathione, protein, and DNA, as well as the stability of quercetin DNA adducts in time. This was done by studying the formation of glutathionyl quercetin adducts in various in vitro models, and the...article 2005
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Wolterbeek, A.P.M. (author), Roberts, A. (author), Korte, H. (author), Unkila, M. (author), Waalkens-Berendsen, D.H. (author), TNO Voeding (author)Plant lignan 7-hydromatairesinol, a novel precursor of the mammalian lignan enterolactone was evaluated in a prenatal developmental toxicity study conducted in the Wistar rat. Mated female rats were fed diets containing 0, 0.25, 1, and 4% (w/w) of 7-hydroxymatairesinol in the form of potassium acetate complex (HMRlignan; potassium acetate level...article 2004
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Brunner, K. (author), van Dijken, A. (author), Börner, H. (author), Bastiaansen, J.J.A.M. (author), Kiggen, N.M.M. (author), Langeveld, B.M.W. (author), TNO Industrie (author)A series of novel carbazole compounds was synthesized and tested for their suitability as host for triplet emitters in an organic-light emitting diode (OLED). In these compounds, a carbazole unit is either connected to other carbazole units to form carbazole dimers and trimers or to fluorene and oxadiazole derivatives to form mixed compounds....article 2004
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Sengupta, S. (author), Toh, S.A. (author), Sellers, L.A. (author), Skepper, J.N. (author), Koolwijk, P. (author), Leung, H.W. (author), Yeung, H.W. (author), Wong, R.N.S. (author), Sasisekharan, R. (author), Fan, T.P.D. (author)Background-Ginseng is a commonly used nutraceutical. Intriguingly, existing literature reports both wound-healing and antitumor effects of ginseng extract through opposing activities on the vascular system. To elucidate this perplexity, we merged a chemical fingerprinting approach with a deconstructional study of the effects of pure molecules...article 2004
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Martin, A.H. (author), Meinders, M.B.J. (author), Bos, M.A. (author), Cohen Stuart, M.A. (author), van Vliet, T. (author)From absorption spectra obtained with infrared reflection - absorption spectroscopy (IRRAS), it is possible to obtain information on conformational changes at a secondary folding level of proteins adsorbed at the air/water interface. In addition, information on protein concentration at the interface can be retrieved by means of spectral...article 2003
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van Zanden, J.J. (author), Hamman, O.B. (author), van Iersel, M.L.P.S. (author), Boeren, S. (author), Cnubben, N.H.P. (author), Lo Bello, M. (author), Vervoort, J. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author)In the present study, the inhibition of human glutathione S-transferase P1-1 (GSTP1-1) by the flavonoid quercetin has been investigated. The results show a time- and concentration-dependent inhibition of GSTP1-1 by quercetin. GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 μM quercetin or 2 h incubation with 25 μM quercetin...article 2003
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Derksen, G.C.H. (author), Naayer, M. (author), van Beek, T.A. (author), Capelle, A. (author), Haaksman, I.K. (author), van Doren, H.A. (author), de Groot, Æ. (author)For the production of a commercially useful dye extract from madder, the glycoside ruberythric acid has to be hydrolysed to the aglycone alizarin which is the main dye component. An intrinsic problem is the simultaneous hydrolysis of the glycoside lucidin pritneveroside to the unwanted mutagenic aglycone lucidin. Madder root was treated with...article 2003
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Nieuwenhuizen, W.F. (author), van Leeuwen, S. (author), Götz, F. (author), Egmond, M.R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Ceramidase (CDase) hydrolyses the N-acyl linkage of the sphingolipid ceramide. We synthesized the non-fluorescent ceramide analogue (4E,2S,3R)-2-N-(10-pyrenedecanoyl)-1,3,17-trihydroxy-17- (3,5-dinitrobenzoyl)-4-heptadecene (10) that becomes fluorescent upon hydrolysis of its N-acyl bond. This novel substrate was used to study several kinetic...article 2002
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Soffers, A.E.M.F. (author), Boersma, M.G. (author), Vaes, W.H.J. (author), Vervoort, J. (author), Tyrakowska, B. (author), Hermens, J.L.M. (author), Rietjens, I.M.C.M. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Over the past decades the description of quantitative structure-activity relationships (QSARs) has been undertaken in order to find predictive models and/or mechanistic explanations for chemical as well as biological activities. This includes QSAR studies in toxicology. In an approach beyond the classical QSAR approaches, attempts have been made...article 2001
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Lake, B.G. (author), Rumsby, P.C. (author), Price, R.J. (author), Cunninghame, M.E. (author), TNO BIBRA TNO Kwaliteit van Leven (author)The objective of this study was to evaluate species differences in the hepatic effects of three potent rodent peroxisome proliferators, namely methylclofenapate (MCP), ciprofibrate (CIP) and Wy-14,643 (WY), particularly with respect to effects on replicative DNA synthesis and transforming growth factor-β1 (TGF-β1) gene expression. Male Sprague...article 2000
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Weidisch, R. (author), Michler, G.H. (author), Fischer, H. (author), Arnold, M. (author), Hofmann, S. (author), Stamm, M. (author), Technisch Physische Dienst TNO - TH (author)Mechanical properties of poly(styrene-b-n-butylmethacrylate) diblock copolymers, PS-b-PBMA, with different lengths of the polystyrene block were investigated. The copolymers display a composition range where the tensile strength of the block copolymers exceeds the values of the corresponding homopolymers. At a PS-content of 74 vol% not only the...article 1999
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Pestman, J.M. (author), Kevelam, J. (author), Blandamer, M.J. (author), van Doren, H.A. (author), Kellogg, R.M. (author), Engberts, J.B.F.N. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Eight homologous series of nonionic carbohydrate-derived surfactants in which the alkyl chains are linked through N-acylated amine bonds were synthesized, and their critical micelle concentrations (cmc's) and standard enthalpies of micellization were determined using titration microcalorimetry. Gibbs energies of micellization (ΔmicG°) were...article 1999
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Weidisch, R. (author), Stamm, M. (author), Michler, G.H. (author), Fischer, H.R. (author), Jérôme, R. (author), Technisch Physische Dienst TNO - TH (author)Poly(styrene-b-butyl methacrylate) diblock copolymers, PS-6-PBMA, with different morphologies are investigated with respect to the influence of strain rate and temperature on tensile properties. In the first part the mechanical properties of bicontinuous and perforated lamellar structure are compared with other morphologies. Diblock copolymers...article 1999
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Kleter, G.A. (author), Damen, J.J.M. (author), van den Kettenes-Bosch, J.J. (author), Bank, R.A. (author), te Koppele, J.M. (author), Veraart, J.R. (author), ten Cate, J.M. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)The aim was to identify suspect collagen cross-links in dentine, eluting close to known cross-links in ion-exchange HPLC. Bovine tooth roots as source of dentine were powdered, demineralised, reduced, and acid-hydrolysed. Cross-linking amino acids were isolated from the acid hydrolysate by size exclusion, adsorption, and sequential ion exchange...article 1998
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