Searched for: subject:"Models%2C%5C+Statistical"
(1 - 20 of 39)

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Fransman, W. (author)
[No abstract available]
article 2018
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Schinkel, J. (author), Fransman, W. (author), Heussen, H. (author), Kromhout, H. (author), Marquart, H. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)
Objectives: For regulatory risk assessment under REACH a tiered approach is proposed in which the first tier models should provide a conservative exposure estimate that can discriminate between scenarios which are of concern and those which are not. The Stoffenmanager is mentioned as a first tier approach in the REACH guidance. In an attempt to...
article 2010
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Thissen, U. (author), Wopereis, S. (author), van den Berg, S.A.A. (author), Bobeldijk, I. (author), Kleemann, R. (author), Kooistra, T. (author), van Dijk, K.W. (author), van Ommen, B. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)
Background: In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant information while diminishing unwanted variation (noise). Knowledge about the study design can be used to decompose the total data...
article 2009
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de Jong, E. (author), Louisse, J. (author), Verwei, M. (author), Blaauboer, B.J. (author), van de Sandt, J.J.M. (author), Woutersen, R.A. (author), Rietjens, I.M.C.M. (author), Piersma, A.H. (author), TNO Kwaliteit van Leven (author)
The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classes. Evaluation within a distinct class of chemically related compounds can define the usefulness...
article 2009
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Steeneken, P.A.M. (author), Woortman, A.J.J. (author), TNO Kwaliteit van Leven (author)
The occurrence of surface effects in the acetylation of granular potato starch with acetic anhydride to degrees of substitution 0.04-0.2 was studied by two different approaches. The first approach involved the fractionation of granular starch acetates into five different size classes and analysis of their acetate content. Alternatively, two...
article 2008
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Joling, C.I. (author), Blatter, B.M. (author), Ybema, J.F. (author), Bongers, P.M. (author), TNO Kwaliteit van Leven (author)
Objectives. This study investigated whether work dedication and job resources are longitudinally related to work-related musculoskeletal disorders and whether job resources buffer the impact of job demands on these disorders? Methods. Data were used from a longitudinal three-phase study (2004, 2005, 2006) on health at work among a sample of...
article 2008
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Kruizinga, A.G. (author), Briggs, D. (author), Crevel, R.W.R. (author), Knulst, A.C. (author), Bosch, L.M.C.v.d. (author), Houben, G.F. (author), TNO Kwaliteit van Leven (author), KvL (author)
Previously, TNO developed a probabilistic model to predict the likelihood of an allergic reaction, resulting in a quantitative assessment of the risk associated with unintended exposure to food allergens. The likelihood is estimated by including in the model the proportion of the population who is allergic, the proportion consuming the food and...
article 2008
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Hageman, J.A. (author), Hendriks, M.M.W.B. (author), Westerhuis, J.A. (author), van der Werf, M.J. (author), Berger, R. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author), KvL (author)
One of the new expanding areas in functional genomics is metabolomics: measuring the metabolome of an organism. Data being generated in metabolomics studies are very diverse in nature depending on the design underlying the experiment. Traditionally, variation in measurements is conceptually broken down in systematic variation and noise where the...
article 2008
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Loizou, G. (author), Spendiff, M. (author), Barton, H.A. (author), Bessems, J. (author), Bois, F.Y. (author), d'Yvoire, M.B. (author), Buist, H. (author), Clewell III, H.J. (author), Meek, B. (author), Gundert-Remy, U. (author), Goerlitz, G. (author), Schmitt, W. (author), TNO Kwaliteit van Leven (author), KvL (author)
The increasing use of tissue dosimetry estimated using pharmacokinetic models in chemical risk assessments in various jurisdictions necessitates the development of internationally recognized good modelling practice (GMP). These practices would facilitate sharing of models and model evaluations and consistent applications in risk assessments....
article 2008
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Spanjersberg, M.Q.I. (author), Kruizinga, A.G. (author), Rennen, M.A.J. (author), Houben, G.F. (author), TNO Kwaliteit van Leven (author)
In order to assess the risk of unintended exposure to food allergens, traditional deterministic risk assessment is usually applied, leading to inconsequential conclusions as 'an allergic reaction cannot be excluded'. TNO therefore developed a quantitative risk assessment model for allergens based on probabilistic techniques resulting in a more...
article 2007
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Jacobusse, G. (author), van Buuren, S. (author), TNO Kwaliteit van Leven (author)
Developmental indicators that are used for routine measurement in The Netherlands are usually chosen to optimally identify delayed children. Measurements on the majority of children without problems are therefore quite imprecise. This study explores the use of computerized adaptive testing (CAT) to monitor the development of young children. CAT...
article 2007
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van Buuren, S. (author), TNO Kwaliteit van Leven (author)
The goal of multiple imputation is to provide valid inferences for statistical estimates from incomplete data. To achieve that goal, imputed values should preserve the structure in the data, as well as the uncertainty about this structure, and include any knowledge about the process that generated the missing data. Two approaches for imputing...
article 2007
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Nueda, M.J. (author), Conesa, A. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Smilde, A.K. (author), Talón, M. (author), Ferrer, A. (author), TNO Kwaliteit van Leven (author)
Motivation: Designed microarray experiments are used to investigate the effects that controlled experimental factors have on gene expression and learn about the transcriptional responses associated with external variables. In these datasets, signals of interest coexist with varying sources of unwanted noise in a framework of (co)relation among...
article 2007
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Heymans, M.W. (author), van Buuren, S. (author), Knol, D.L. (author), van Mechelen, W. (author), de Vet, H.C.W. (author), TNO Kwaliteit van Leven (author)
Background. Missing data is a challenging problem in many prognostic studies. Multiple imputation (MI) accounts for imputation uncertainty that allows for adequate statistical testing. We developed and tested a methodology combining MI with bootstrapping techniques for studying prognostic variable selection. Method. In our prospective cohort...
article 2007
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Vis, D.J. (author), Westerhuis, J.A. (author), Smilde, A.K. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
Background: Innovative extensions of (M) ANOVA gain common ground for the analysis of designed metabolomics experiments. ASCA is such a multivariate analysis method; it has successfully estimated effects in megavariate metabolomics data from biological experiments. However, rigorous statistical validation of megavariate effects is still...
article 2007
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Jacobusse, G. (author), van Buuren, S. (author), Verkerk, P.H. (author)
Measurement of development is often less precise than that of height and weight. Developmental scores are typically based on passing one or more developmental markers, but do not have interval scale so calculating differences between scores can be nonsensical. Age-specific standardized scores are sometimes used, but fail to have a common metric...
article 2006
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Miedema, H.M.E. (author), Groothuis-Oudshoorn, C.G.M. (author), TNO Bouw en Ondergrond (author)
A method for modeling the relationship of polychotomous health ratings with predictors such as area characteristics, the distance to a source of environmental contamination, or exposure to environmental pollutants is presented. The model combines elements of grouped regression and multilevel analysis. The statistical model describes the entire...
article 2006
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Bemelmans, W.J.E. (author), van Lenthe, F. (author), Hoogenveen, R. (author), Kunst, A. (author), Deeg, D.J.H. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Verschuren, W.M.M. (author), TNO Kwaliteit van Leven (author)
Background and Objective: To estimate the effects of reducing the prevalence of smoking in lower educated groups on educational differences in life expectancy. Methods: A dynamic Markov-type multistate transition model estimated the effects on life expectancy of two scenarios. A "maximum scenario" where educational differences in prevalence of...
article 2006
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Hoeksma, M. (author), van Rijn, M. (author), Verkerk, P.H. (author), Bosch, A.M. (author), Mulder, M.F. (author), de Klerk, J.B.C. (author), de Koning, T.J. (author), Rubio-Gozalbo, E. (author), de Vries, M. (author), Sauer, P.J.J. (author), van Spronsen, F.J. (author), TNO Preventie en Gezondheid (author)
In a previous study, Dutch children with phenylketonuria (PKU) were found to be slightly shorter than their healthy counterparts. In the literature, it has been hypothesized that a higher protein intake is necessary to optimize growth in PKU patients. The study aimed to investigate whether protein intake (total, natural and protein substitute)...
article 2005
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Hendriks, A.J. (author), Maas-Diepeveen, J.L.M. (author), Heugens, E.H.W. (author), van Straalen, N.M. (author), TNO Kwaliteit van Leven (author)
Most of the thousands of substances and species that are of concern for environmental management will not be investigated empirically at ecologically relevant levels because of financial, practical, and ethical constraints. To allow risk assessment for these less well-known categories, we have developed a mechanistic model with classical...
article 2005
Searched for: subject:"Models%2C%5C+Statistical"
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