Therapeutic effects of Δ9-THC and modafinil in a marmoset Parkinson model

Current therapies for Parkinson's disease (PD) like l-dopa and dopamine (DA) agonists have declined efficacy after long term use. Therefore, research towards supplementary or alternative medication is needed. The implementation in PD can be expedited by application of compounds already used in the clinic. In this study the therapeutic effects of...

Efficacy of caffeine and modafinil in counteracting sleep deprivation in the marmoset monkey

Neuroprotective effects of modafinil in a marmoset Parkinson model: Behavioral and neurochemical aspects

The vigilance-enhancing agent modafinil has neuroprotective properties: it prevents striatal ischemic injury, nigrostriatal pathway deterioration after partial transsection and intoxication with 1-methyl-1,2,3,6-tetrahydropyridine. The present study determines the protective effects of modafinil in the marmoset 1-methyl-1,2,3,6...

Behavioral effects of modafinil in marmoset monkeys

Rationale: Modafinil is increasingly used in sleep disturbances in general and in neurodegenerative diseases and is recently being used in healthy people for attention control. However, the application of modafinil is possibly not only restricted to alertness enhancing effects. More insight in this compound may lead to new applications. Not all...

Human threat test: A method to test anxiety related behavior in a marmoset monkey

The human threat test is a non-human primate putative model of anxiety. It is based on findings that marmosets will exhibit anxiety-related behavior in the presence of a human observer in front of the cage. The test is applied to our marmoset colony to asses the effects of three psychoactive compounds: diazepam, modafinil and Δ9-THC on anxiety...