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Reisinger, K. (author), Blatz, V. (author), Brinkmann, J. (author), Downs, T.R. (author), Fischer, A. (author), Henkler, F. (author), Hoffmann, S. (author), Krul, C. (author), Liebsch, M. (author), Luch, A. (author), Pirow, R. (author), Reus, A.A. (author), Schulz, M. (author), Pfuhler, S. (author)Recently revised OECD Testing Guidelines highlight the importance of considering the first site-of-contact when investigating the genotoxic hazard. Thus far, only in vivo approaches are available to address the dermal route of exposure. The 3D Skin Comet and Reconstructed Skin Micronucleus (RSMN) assays intend to close this gap in the in vitro...article 2018
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Clare, M.G. (author), Lorenzon, G. (author), Akhurst, L.C. (author), Marzin, D. (author), van Delft, J. (author), Montero, R. (author), Botta, A. (author), Bertens, A. (author), Cinelli, S. (author), Thybaud, V. (author), Lorge, E. (author), TNO Kwaliteit van Leven (author)This study on the in vitro micronucleus assay, comprising 11 laboratories using human lymphocytes, was coordinated by an organizing committee supported by the SFTG (the French branch of the European Environmental Mutagen Society). Nine coded substances were assessed for their ability to induce micronuclei in human lymphocytes in vitro, mitomycin...article 2006
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Delaney, B. (author), de Vogel, N. (author), Krul, C.A.M. (author), TNO Voeding (author)Chemicals / CAS: corn oil, 8001-30-7; mitomycin C, 50-07-7, 74349-48-7; Glucans; Mutagensarticle 2004
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Rompelberg, C.J.M. (author), Vogels, J.T.W.E. (author), de Vogel, N. (author), Bruijntjes-Rozier, G.C.D.M. (author), Stenhuis, W.H. (author), Bogaards, J.J.P. (author), Verhagen, H. (author), TNO Voeding (author)1. In order to study the antigenotoxic potential of eugenol in humans, ten healthy non-smoking males ingested a daily amount of 150 mg eugenol or the placebo for seven consecutive days. After a washout period of one week, groups ingesting eugenol or the placebo were crossed and received the other treatment for seven consecutive days. 2. On days...article 1996
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Verhagen, H. (author), Rauma, A.L. (author), Törrönen, R. (author), de Vogel, N. (author), Bruijntjes-Rozier, G.C.D.M. (author), Dreve, M.A. (author), Bogaards, J.J.P. (author), Mykkänen, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)1. In order to study the potential beneficial effects of a vegan diet, a cross-sectional study was performed and several biomarkers of chemoprevention were measured in a population of female 'living food' eaters ('vegans'; n = 20) vs matched omnivorous controls (n = 20). 2. White blood cells obtained from fresh blood samples were subjected to...article 1996
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- Rutten, A.A.J.J.L. (author), Wilmer, J.W.G.M. (author), Instituut CIVO-Toxicologie en voeding TNO (author) article 1986
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Mattern, I.E. (author), Greim, H. (author), Medisch Biologisch Laboratorium TNO (author)Bacterial systems for the screening of chemical substances for mutagenic potential are receiving widespread attention. Now that many laboratories have introduced these test systems and a large number of substances has been tested, discrepancies in the results have become apparent. To discuss this problem, a workshop was organized at Neuherberg ...article 1978