Searched for: subject:"Microbiota"
(1 - 20 of 49)

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van Trijp, M.P.H. (author), Schutte, S. (author), Esser, D. (author), Wopereis, S. (author), Hoevenaars, F.P.M. (author), Hooiveld, G.J.E.J. (author), Afman, L.A. (author)
Background: Whole grain wheat (WGW) products are advocated as a healthy choice when compared with refined wheat (RW). One proposed mechanism for these health benefits is via the microbiota, because WGW contains multiple fibers. WGW consumption has been proposed to ameliorate nonalcoholic fatty liver disease, in which microbiota might play a role...
article 2021
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Rahman, S. (author), Davids, M. (author), van Hamersveld, P.H.P. (author), Welting, O. (author), Rahaoui, H. (author), Schuren, F. (author), Meijer, S.L. (author), van den Wijngaard, R.M. (author), Hakvoort, T.B.M. (author), de Jonge, W.J. (author), Heinsbroek, S.E.M. (author)
β-glucan consumption is known for its beneficial health effects, but the mode of action is unclear. While humans and mice lack the required enzymes to digest β-glucans, certain intestinal microbes can digest β-glucans, triggering gut microbial changes. Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive...
article 2021
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Delzenne, N.M. (author), Olivares, M. (author), Neyrinck, A.M. (author), Beaumont, M. (author), Kjolbaek, L. (author), Larsen, T.M. (author), Benitez-Paez, A. (author), Romani-Perez, M. (author), Garcia-Campayo, V. (author), Bosscher, D. (author), Sanz, Y. (author), van der Kamp, J.W. (author)
The aim of EU project MyNewGut is to contribute to future public health-related recommendations supported by new insight in gut microbiome and nutrition-host relationship. In this Opinion Paper, we first revisit the concept of dietary fiber, taking into account their interaction with the gut microbiota. This paper also summarizes the main...
article 2020
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Wacoo, A.P. (author), Atukunda, P. (author), Muhoozi, G. (author), Braster, M. (author), Wagner, M. (author), van den Broek, T.J. (author), Sybesma, W. (author), Westerberg, A.C. (author), Iversen, P.O. (author), Kort, R. (author)
article 2020
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Fernandez-Gutierrez, M.M. (author), Imangaliyev, S. (author), Loos, B.G. (author), Keijser, B.J.F. (author), Kleerebezem, M. (author)
Several proteins and peptides in saliva were shown to stimulate gingival wound repair, but the role of salivary metabolites in this process remains unexplored. In vitro gingival re-epithelialization kinetics were determined using unstimulated saliva samples from healthy individuals collected during an experimental gingivitis study. Elastic net...
article 2020
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Kaan, A.M. (author), Buijs, M.J. (author), Brandt, B.W. (author), Crielaard, W. (author), Keijser, B.J.F. (author), de Ruyter, J.C. (author), Zaura, E. (author)
Objectives: Large longitudinal cohort studies in infants are needed to understand oral microbiome maturation in relation to general health. The logistics of such studies are complex and costs involved high. Methods like home sampling by caretakers might be a solution to these issues. This study aimed to evaluate feasibility of home sampling by...
article 2020
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Peters, V.B.M. (author), van de Steeg, E. (author), van Bilsen, J. (author), Meijerink, M. (author)
The human body is exposed to many xenobiotic, potentially harmful compounds. The intestinal immune system is crucial in protecting the human body from these substances. Moreover, many microorganisms, residing in the gastrointestinal tract, play an important role in modulating immune responses. Pre- and probiotics may have beneficial effects on...
article 2019
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Dinan, T.G. (author), Stanton, C. (author), Long-Smith, C. (author), Kennedy, P. (author), Cryan, J.F. (author), Cowan, S.S.M. (author), Cenit, M.C. (author), van der Kamp, J.W. (author), Sanz, Y. (author)
Depression is a highly prevalent disorder which exerts a major economic impact in all European countries. The brain-gut-microbiota axis has been described as a new paradigm for advancing understanding and treatment of the disorder. There is now over-whelming evidence to support the fact that gut microbes have a major impact on central...
article 2019
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Perdijk, O. (author), Baarlen, P.V. (author), Fernandez-Gutierrez, M.M. (author), Brink, E.V. (author), Schuren, F.H.J. (author), Brugman, S. (author), Savelkoul, H.F.J. (author), Kleerebezem, M. (author), Neerven, R.J.J.V. (author)
Human milk oligosaccharides (HMO) and prebiotic oligosaccharides are proposed to confer several health benefits to the infant. They shape the microbiota, have anti-inflammatory properties, and support epithelial barrier functioning. However, in order to select the best oligosaccharides for inclusion in infant formulas, there is a need to...
article 2019
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Man, W.H. (author), Clerc, M. (author), de Steenhuijsen Piters, W.A.A. (author), van Houten, M.A. (author), Chu, M.L.J.N. (author), Kool, J. (author), Keijser, B.J.F. (author), Sanders, E.A.M. (author), Bogaert, D. (author)
Rationale: The respiratory microbiota is increasingly being appreciated as an important mediator in the susceptibility to childhood respiratory tract infections (RTIs). Pathogens are presumed to originate from the nasopharyngeal ecosystem. Objectives: To investigate the association between early life respiratory microbiota and development of...
article 2019
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Collins, S.L. (author), McMillan, A. (author), Seney, S. (author), van der Veer, C. (author), Kort, R. (author), Sumarah, M.W. (author), Reid, G. (author)
Perturbations to the vaginal microbiota can lead to dysbiosis, including bacterial vaginosis (BV), which affects a large portion of the female population. In a healthy state, the vaginal microbiota is characterized by low diversity and colonization by Lactobacillus spp., whereas in BV, these species are displaced by a highly diverse population...
article 2018
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Sanz, Y. (author), Romaní-Perez, M. (author), Benítez-Páez, A. (author), Portune, K.J. (author), Brigidi, P. (author), Rampelli, S. (author), Dinan, T. (author), Stanton, C. (author), Delzenne, N. (author), Blachier, F. (author), Neyrinck, A.M. (author), Beaumont, M. (author), Olivares, M. (author), Holzer, P. (author), Günther, K. (author), Wolters, M. (author), Ahrens, W. (author), Claus, S.P. (author), van der Kamp, J.W. (author)
The gut microbiota coexists in partnership with the human host through adaptations to environmental and physiological changes that help maintain dynamic homeostatic healthy states. Break-down of this delicate balance under sustained exposure to stressors (e.g. unhealthy diets) can, however, contribute to the onset of disease. Diet is a key...
article 2018
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van der Does, A.M. (author), Amatngalim, G.D. (author), Keijser, B.J.F. (author), Hiemstra, P.S. (author), Villenave, R. (author)
The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of...
article 2018
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Fieten, K.B. (author), Totté, J.E.E. (author), Levin, E. (author), Reyman, M. (author), Meijer, Y. (author), Schuren, F.H.J. (author), Pasmans, S.G.M.A. (author), Pasmans, S.G.M.A. (author)
Background: Exposure to microbes may be important in the development of atopic disease. Atopic diseases have been associated with specific characteristics of the intestinal microbiome. The link between intestinal microbiota and food allergy has rarely been studied, and the gold standard for diagnosing food allergy (double-blind placebo...
article 2018
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Keijser, B.J.F. (author), van den Broek1, T.J. (author), Slot, D.E. (author), van Twillert, L. (author), Kool, J. (author), Thabuis, C. (author), Ossendrijver, M. (author), van der Weijden, F.A. (author), Montijn, R.C. (author)
Background: The oral cavity harbors a complex microbial ecosystem, intimately related to oral health and disease. The use of polyol-sweetened gum is believed to benefit oral health through stimulation of salivary flow and impacting oral pathogenic bacteria. Maltitol is often used as sweetener in food products. This study aimed to establish the...
article 2018
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Schutte, S. (author), Esser, D. (author), Hoevenaars, F.P.M. (author), Hooiveld, G.J.E.J. (author), Priebe, M.G. (author), Vonk, R.J. (author), Wopereis, S. (author), Afman, L.A. (author)
Background: Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions. Objective: The aim of this...
article 2018
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Botschuijver, S. (author), Roeselers, G. (author), Levin, E. (author), Jonkers, D.M. (author), Welting, O. (author), Heinsbroek, S.E.M. (author), de Weerd, H.H. (author), Boekhout, T. (author), Fornai, M. (author), Masclee, A.A. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), Seppen, J. (author), van den Wijngaard, R.M. (author)
Background & Aims Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in the activation of nociceptive sensory pathways, but there have been few studies of the role of the mycobiome (the fungal microbiome) in the development of IBS. We analyzed intestinal mycobiomes of patients with...
article 2017
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Bosch, A.A.T.M. (author), de Steenhuijsen Piters, W.A.A. (author), van Houten, M.A. (author), Chu, M.L.J.N. (author), Biesbroek, G. (author), Kool, J. (author), Pernet, P. (author), de Groot, P.C.M. (author), Eijkemans, M.J.C. (author), Keijser, B.J.F.5. (author), Sanders, E.A.M. (author), Bogaert, D. (author)
RATIONALE: Perinatal and postnatal influences are presumed important drivers of the early-life respiratory microbiota composition. We hypothesized that the respiratory microbiota composition and development in infancy is affecting microbiota stability and thereby resistance against respiratory tract infections (RTIs) over time. OBJECTIVES: To...
article 2017
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Fluitman, K.S. (author), de Clercq, N.C. (author), Keijser, B.J.F. (author), Visser, M. (author), Nieuwdorp, M. (author), Ijzerman, R.G. (author)
Introduction: Malnutrition refers to both over- and undernutrition and results from a disruption in energy balance. It affects one in three people worldwide and is associated with increased morbidity and mortality. The intestinal microbiota represents a newly identified factor that might contribute to the development of malnutrition, as it...
article 2017
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Aguirre, M. (author), Venema, K. (author)
There is an elevated incidence of cases of obesity worldwide. Therefore, the development of strategies to tackle this condition is of vital importance. This review focuses on the necessity of optimising in vitro systems to model human colonic fermentation in obese subjects. This may allow to increase the resolution and the physiological...
article 2017
Searched for: subject:"Microbiota"
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