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Bajard, L. (author), Adamovsky, O. (author), Audouze, K. (author), Baken, K. (author), Barouki, R. (author), Beltman, J. (author), Beronius, A. (author), Bonefeld-Jørgensen, E.C. (author), Cano-Sancho, G. (author), de Baat, M.L. (author), Di Tillio, F. (author), Fernández, M.F. (author), FitzGerald, R.E. (author), Gundacker, C. (author), Hernández, A.F. (author), Hilscherova, K. (author), Karakitsios, S. (author), Kuchovska, E. (author), Long, M. (author), Luijten, M. (author), Majid, S. (author), Marx-Stoelting, P. (author), Mustieles, V. (author), Negi, C.K. (author), Sarigiannis, D. (author), Scholz, S. (author), Sovadinova, I. (author), Stierum, R. (author), Tanabe, S. (author), Tollefsen, K.E. (author), van den Brand, A.D. (author), Vogs, C. (author), Wielsøe, M. (author), Wittwehr, C. (author), Blaha, L. (author)While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. Moreover, human epidemiological studies with biomarkers of effect (BoE) also play an invaluable role in...article 2023
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Krul, C. (author), de Moor, A. (author), Stegmeijer, K. (author), Stoop, R. (author), van Luijk, J. (author), Prins, J.B. (author)While the original definition of replacement focuses on the replacement of the use of animals in science, a more contemporary definition focuses on accelerating the development and use of predictive and robust models, based on the latest science and technologies, to address scientific questions without the use of animals. The transition to...article 2023
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- Kamphorst, B. (author), Rooijakkers, T. (author), Veugen, T. (author), Cellamare, M. (author), Knoors, D. (author) article 2022
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Fratric, P. (author), Sileno, G. (author), van Engers, T. (author), Klous, S. (author)The financial sector continues to experience wide digitalization; the resulting transactional activity creates large amounts of data, in principle enabling public and private actors to better understand the social domain they operate on, possibly facilitating the design of interventions to reduce illegal activity. However, the adversarial nature...conference paper 2022
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Kermavnar, T. (author), de Vries, A.W. (author), de Looze, M.P. (author), O'Sullivan, L.W. (author)This study is an updated systematic review of papers published in the last 5 years on industrial back-support exoskeletons. The research questions were aimed at addressing the recent findings regarding objective (e.g. body loading, user performance) and subjective evaluations (e.g. user satisfaction), potential side effects, and methodological...article 2021
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Small, J. (author), van Hoek, C. (author), van der Does, F. (author), Seinen, A.B. (author), Melzer, S. (author), Tromp, P.C. (author), van der Laan, S. (author)A method has been developed to screen large numbers (~103–104 per sample) of coarse airborne dust particles for the occurrence of Pb-rich phases, together with quantification of the particles’ mineralogy, chemistry, and inferred provenance. Using SEM-EDS spectral imaging (SI) at 15 kV, and processing with the custom software PARC, screening of...article 2021
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van Hees, S.G.M. (author), Bouwine, C. (author), Blonk, R.W.B. (author), Oomens, S. (author)BACKGROUND: Work participation among employees with common mental disorders (CMDs) is an increasingly important, yet highly complex phenomenon. Given the call for preventing instead of reacting to negative work outcomes, there is a need to understand how employees with CMDs can continue working. OBJECTIVES: 1) to provide insights in applying a...article 2021
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Bouter, C. (author), Pourjafarian, M. (author), Simar, L. (author), Wilterdink, R. (author)The Industry 4.0 Asset Administration Shell is designed as a digital communication interface that exposes information of various aspects of an asset in Submodels, which are functional blocks. However, a methodology that identifies the set of Submodels required for a specific use case is lacking. This work therefore presents two results: 1) the...conference paper 2021
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Alvarez, C.M. (author), Ligthart, T. (author)PurposeThis literature review aims to present the current methodologies that have been developed to perform a social life cycle assessment (sLCA) and to display the main differences among them. In addition to that, to identify the nexus between sLCA and circular economy (CE) and to what extent this life cycle technique has been involved within...article 2021
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Numan, N. (author), Haar, F.T. (author), Cesar, P. (author)Head-mounted displays (HMDs) are an essential display device for the observation of virtual reality (VR) environments. However, HMDs obstruct external capturing methods from recording the user’s upper face. This severely impacts social VR applications, such as teleconferencing, which commonly rely on external RGB-D sensors to capture a...conference paper 2021
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Austin, P.C. (author), White, I.R. (author), Lee, D.S. (author), van Buuren, S. (author)Missing data is a common occurrence in clinical research. Missing data occurs when the value of the variables of interest are not measured or recorded for all subjects in the sample. Common approaches to addressing the presence of missing data include complete-case analyses, in which subjects with missing data are excluded, or mean-value...article 2021
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Nymark, P. (author), Bakker, M. (author), Dekkers, S. (author), Franken, R. (author), Fransman, W. (author), García-Bilbao, A. (author), Greco, D. (author), Gulumian, M. (author), Hadrup, N. (author), Halappanavar, S. (author), Hongisto, V. (author), Hougaard, K. (author), Jensen, K. (author), Kohonen, P. (author), Koivisto, A.J. (author), Dal Maso, M. (author), Oosterwijk, T. (author), Poikkimäki, M. (author), Rodriguez-Llopis, I. (author), Stierum, R. (author), Sørli, J.B. (author), Grafström, R. (author)Advanced material development, including at the nanoscale, comprises costly and complex challenges coupled to ensuring human and environmental safety. Governmental agencies regulating safety have announced interest toward acceptance of safety data generated under the collective term New Approach Methodologies (NAMs), as such technologies...article 2020
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Hellingrath, B. (author), Widera, A. (author), Bonnamour, M.C. (author), Lund, D. (author), Fonio, C. (author), Stolk, D.J. (author), Dubost, L. (author), Pasedag, K. (author), Gerevini, M. (author), Zwęgliński, T. (author), Friedemann, M. (author)Describes a pragmatic methodology for the assessment of innovative solutions in the area of crisis management. The results of this project together with this CWA will be used to establish a methodology that will: — enable practitioners to systematically assess the added value of an innovative solution; — enhance dialogue and co-operation among...report 2020
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Sewell, F. (author), Strupp, C. (author), van der Laan, J.W. (author), Wolf, D.C. (author), Wolterink, G. (author), Woutersen, R. (author), Zvonar, Z. (author), Heusinkveld, H. (author), Braakhuis, H. (author)Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies. However, these involve the use of large numbers of animals and the relevance of their predictive power and results has been scientifically challenged. With increased availability of innovative...article 2020
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Franken, R. (author), Shandilya, N. (author), Marquart, H. (author), McNally, K. (author), Fransman, W. (author)Measured data are generally preferred to modelled estimates of exposure. Grouping and read-across is already widely used and accepted approach in toxicology, but an appropriate approach and guidance on how to use existing exposure measurement data on one substance and work situation for another substance and/or work situation is currently not...article 2020
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Cacciatore, P. (author), Visser, L.A. (author), Buyukkaramikli, N. (author), van der Ploeg, C.P.B. (author), van den Akker-van Marle, M.E. (author)Introduction: Cost-effectiveness (CEA) and cost–utility analyses (CUA) have become popular types of economic evaluations (EE) used for evidence-based decision-making in healthcare resource allocation. Newborn screening programs (NBS) can have significant clinical benefits for society, and cost-effectiveness analysis may help to select the...article 2020
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Krone, T. (author), Boessen, R. (author), Bijlsma, S. (author), van Stokkum, R. (author), Clabbers, N.D.S. (author), Pasman, W.J. (author)Background. N-of-1 designs gain popularity in nutritional research because of the improving technological possibilities, practical applicability and promise of increased accuracy and sensitivity, especially in the field of personalized nutrition. This move asks for a search of applicable statistical methods. Objective. To demonstrate the...article 2020
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Verhoeckx, K. (author), lindholm Bøgh, K. (author), Constable, A. (author), Epstein, M.M. (author), hoffmann Sommergruber, K. (author), Holzhauser, T. (author), Houben, G. (author), Kuehn, A. (author), Roggen, E. (author), O'Mahony, L. (author), Remington, B. (author), Crevel, R. (author)The growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources such as insects, algae and duckweed and using new processing techniques. Consumer exposure to these novel or processed proteins, could...article 2020
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Remington, B.C. (author), Blom, W.M. (author), Bassa, B. (author), Koppelman, S.J. (author)Allergic reactions to meals consumed outside the home are common and can be severe and sometimes fatal. Objective. To quantify the risk reduction potentially achieved by increasing an individual’s threshold sensitivity to peanut (such as by means of immunotherapy) in scenarios of peanut exposure through shared kitchen materials in a restaurant...article 2020
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Vasenev, A. (author), Stahl, F. (author), Hamazaryan, H. (author), Ma, Z. (author), Shan, L. (author), Kemmerich, J. (author), Loiseaux, C. (author)Keeping a vehicle secure implies provide of a long-term support, where over-the-air updates (OTA) play an essential role. Clear understanding of OTA threats is essential to counter them efficiently. Existing research on OTA threats often exclude human actors, such as drivers and maintenance personnel, as well as leave aside privacy threats. This...conference paper 2019