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van Stee, M.F. (author), de Graaf, A.A. (author), Groen, A.K. (author)Patients with diabetes type 2 have an increased risk for cardiovascular disease and commonly use combination therapy consisting of the anti-diabetic drug metformin and a cholesterol-lowering statin. However, both drugs act on glucose and lipid metabolism which could lead to adverse effects when used in combination as compared to monotherapy. In...article 2018
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den Ouden, H. (author), Pellis, L. (author), Rutten, G.E.H.M. (author), Geerars-van Vonderen, I.K. (author), Rubingh, C.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Beulens, J.W.J. (author)We aimed to identify metabolites to predict patients’ response to glucose lowering treatment during the first 5 years after detection of type 2 diabetes. Metabolites were measured by GC–MS in baseline samples from 346 screen-detected type 2 diabetes patients in the ADDITION-NL study. The response to treatment with metformin and/or sulphonylurea ...article 2016
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Wagner, A. (author), Cohen, N. (author), Kelder, T. (author), Amit, U. (author), Liebman, E. (author), Steinberg, D.M. (author), Radonjic, M. (author), Ruppin, E. (author)High-throughput omics have proven invaluable in studying human disease, and yet day-to-day clinical practice still relies on physiological, non-omic markers. The metabolic syndrome, for example, is diagnosed and monitored by blood and urine indices such as blood cholesterol levels. Nevertheless, the association between the molecular and the...article 2015
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Oostdam, N. (author), van Poppel, M.N.M. (author), Wouters, M.G.A.J. (author), van Mechelen, W. (author)Background: The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide. GDM is associated with increased risks for mother and child during pregnancy and in later life. The aim of this article is to systematically review literature on the effectiveness of interventions to prevent GDM. Methods: Controlled trials found in PubMed,...article 2011
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Manders, R.J. (author), Koopman, R. (author), Sluijsmans, W.E. (author), van den Berg, R. (author), Verbeek, K. (author), Saris, W.H. (author), Wagenmakers, A.J. (author), van Loon, L.J. (author), TNO Kwaliteit van Leven (author)This study examined postprandial plasma insulin and glucose responses after co-ingestion of an insulinotropic protein (Pro) hydrolysate with and without additional free leucine with a single bolus of carbohydrate (Cho). Male patients with long-standing Type 2 diabetes (n = 10) and healthy controls (n = 10) participated in 3 trials in which...article 2006
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van der Greef, J. (author), TNO Kwaliteit van Leven (author)The concept of systems-based strategies in medicine is emerging, with systems pathology guiding an understanding of the multidimensional aspects of disease system fingerprints and systems pharmacology providing insight into dynamic system responses upon (multiple) drug perturbations. Knowledge of the changes of system characteristics during...article 2005
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Renders, C.M. (author), Delemarre-van De Waal, H.A. (author), Dekker, J.M. (author), Hirasing, R.A. (author)The prevalence of overweight and obesity in children is increasing significantly. This increase is attended by an increase in diabetes type 2 in children and adolescents. The most important risk factor for the rise of insulin resistance amongst young people is overweight. The diagnostic criteria for diabetes mellitus in young people are: (a)...article 2003