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Gijbels, A. (author), Schutte, S. (author), Esser, D. (author), Wopereis, S. (author), Gonzales, G.B. (author), Afman, L.A. (author)Background: We previously showed that whole-grain wheat (WGW) consumption had beneficial effects on liver fat accumulation, as compared to refined wheat (RW). The mechanisms underlying these effects remain unclear. Objective: In this study, we investigated the effects of WGW vs. RW consumption on plasma metabolite levels to explore potential...article 2022
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Olga, L. (author), Bobeldijk-Pastorova, I. (author), Bas R.C., (author), Seidel, F. (author), Snowden, S.G. (author), Furse, S. (author), Ong, K.K. (author), Kleemann, R. (author), Koulman, A. (author)This protocol outlines a translational lipidomic approach to discover lipid biomarkers that could predict morphometric body and histological organ measurements (e.g., weight and adiposity gains) during specific stages of life (e.g., early life). We describe procedures ranging from animal experimentation and histological analyses to downstream...article 2022
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HDHL-INTIMIC: A European Knowledge Platform on Food, Diet, Intestinal Microbiomics, and Human HealthAgamennone, V. (author), Abuja, P.M. (author), Basic, M. (author), De Angelis, M. (author), Gessner, A. (author), Keijser, B. (author), Larsen, M. (author), Pinart, M. (author), Nimptsch, K. (author), Pujos-Guillot, E. (author), Schlicht, K. (author), Sharon, I. (author), Untersmayr, E. (author), Laudes, M. (author), ischon, T. (author), Bouwman, J. (author)Studies indicate that the intestinal microbiota influences general metabolic processes in humans, thereby modulating the risk of chronic diseases such as type 2 diabetes, allergy, cardiovascular disease, and colorectal cancer (CRC). Dietary factors are also directly related to chronic disease risk, and they affect the composition and function of...article 2022
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Li, L. (author), Hoefsloot, H. (author), de Graaf, A.A. (author), Acar, E. (author), Smilde, A.K. (author)Background: Analysis of dynamic metabolomics data holds the promise to improve our understanding of underlying mechanisms in metabolism. For example, it may detect changes in metabolism due to the onset of a disease. Dynamic or time-resolved metabolomics data can be arranged as a three-way array with entries organized according to a subjects...article 2022
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Pinart, M. (author), Nimptsch, K. (author), Forslund, S.F. (author), Schlicht, K. (author), Gueimonde, M. (author), Brigidi, P. (author), Turroni, S. (author), Ahrens, W. (author), Hebestreit, A. (author), Wolters, M. (author), Dötsch, A. (author), Nöthlings, U. (author), Oluwagbemigun, K. (author), Cuadrat, R.R.C. (author), Schulze, M.B. (author), Standl, M. (author), Schloter, M. (author), De Angelis, M. (author), Iozzo, P. (author), Guzzardi, M.G. (author), Vlaemynck, G. (author), Penders, J (author), Jonkers, D.M.A.E. (author), Stemmer, M. (author), Chiesa, G. (author), Cavalieri, D. (author), De Filippo, C. (author), Ercolini, D. (author), De Filippis, F. (author), Ribet, D. (author), Achamrah, N. (author), Tavolacci, M.P. (author), Déchelotte, P. (author), Bouwman, J. (author), Laudes, M. (author), Pischon, T. (author)In any research field, data access and data integration are major challenges that even large, well-established consortia face. Although data sharing initiatives are increasing, joint data analyses on nutrition and microbiomics in health and disease are still scarce. We aimed to identify observational studies with data on nutrition and gut...article 2021
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Salic, K. (author), Gart, E. (author), Verschuren, L. (author), van Duyvenvoorde, W. (author), Wong, K.E. (author), Keijer, J. (author), Bobeldijk-Pastorova, I. (author), Wielinga, P.Y. (author), Kleemann, R. (author)Obesity characterized by adiposity and ectopic fat accumulation is associated with the development of non-alcoholic fatty liver disease (NAFLD). Treatments that stimulate lipid utilization may prevent the development of obesity and comorbidities. This study evaluated the potential anti-obesogenic hepatoprotective effects of combined treatment...article 2019
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Fiamoncini, J. (author), Rundle, M. (author), Gibbons, H. (author), Thomas, E.L. (author), Geillinger-Kästle, K. (author), Bunzel, D. (author), Trezzi, J.P. (author), Kiselova-Kaneva, Y. (author), Wopereis, S. (author), Wahrheit, J. (author), Kulling, S.E. (author), Hiller, K. (author), Sonntag, D. (author), Ivanova, D. (author), van Ommen, B. (author), Frost, G. (author), Brennan, L. (author), Bell, J. (author), Daniel, H. (author)Health has been defined as the capability of the organism to adapt to challenges. In this study,we tested to what extent comprehensively phenotyped individuals reveal differences in metabolic responses to a standardized mixed meal tolerance test (MMTT) and how these responses change when individuals experience moderate weight loss. Metabolome...article 2018
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Vitali, F. (author), Lombardo, R. (author), Rivero, D. (author), Mattivi, F. (author), Franceschi, P. (author), Bordoni, A. (author), Trimigno, A. (author), Capozzi, F. (author), Felici, G. (author), Taglino, F. (author), Miglietta, F. (author), de Cock, N. (author), Lachat, C. (author), de Baets, B. (author), de Tré, G. (author), Pinart, M. (author), Nimptsch, K. (author), Pischon, T. (author), Bouwman, J. (author), Cavalieri, D. (author)Background: The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semantic interpretations that specific research fields or communities are used to. To date, a proper ontology to structure and...article 2018
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He, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), Wang, M. (author), Sun, M. (author), Koval, S. (author), van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author)The increasing prevalence of rheumatoid arthritis has driven the development of new approaches and technologies for investigating the pathophysiology of this devastating, chronic disease. From the perspective of systems biology, combining comprehensive personal data such as metabolomics profiling with ultra-weak photon emission (UPE) data may...article 2017
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Brouwer-Brolsma, E.M. (author), Brennan, L. (author), Drevon, C.A. (author), van Kranen, H. (author), Manach, C. (author), Dragsted, L.O. (author), Roche, H.M. (author), Andres-Lacueva, C. (author), Bakker, S.J.L. (author), Bouwman, J. (author), Capozzi, F. (author), de Saeger, S. (author), Gundersen, T.E. (author), Kolehmainen, M. (author), Kulling, S.E. (author), Landberg, R. (author), Linseisen, J. (author), Mattivi, F. (author), Mensink, R.P. (author), Scaccini, C. (author), Skurk, T. (author), Tetens, I. (author), Vergeres, G. (author), Wishart, D.S. (author), Scalbert, A. (author), Feskens, E.J.M. (author)FFQ, food diaries and 24 h recall methods represent the most commonly used dietary assessment tools in human studies on nutrition and health, but food intake biomarkers are assumed to provide a more objective reflection of intake. Unfortunately, very few of these biomarkers are sufficiently validated. This review provides an overview of food...article 2017
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Pantophlet, A.J. (author), Wopereis, S. (author), Eelderink, C. (author), Vonk, R.J. (author), Stroeve, J.H. (author), Bijlsma, S. (author), van Stee, L. (author), Bobeldijk, I. (author), Priebe, M.G. (author)Background: The consumption of products rich in cereal fiber and with a low glycemic index is implicated in a lower risk of metabolic diseases. Previously, we showed that the consumption of fiber-rich pasta compared with bread resulted in a lower rate of appearance of exogenous glucose and a lower glucose clearance rate quantified with a dual...article 2017
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Burgos, R.C.R. (author), Cervinková, K. (author), van der Laan, T. (author), Ramautar, R. (author), van Wijk, E.P.A. (author), Cifra, M. (author), Koval, S. (author), Berger, R. (author), Hankemeier, T. (author), van der Greef, J. (author)Ultra-weak photon emission (UPE) is light emitted spontaneously by biological systems without the use of specific luminescent complexes. UPE is emitted in the near-UV/UV–Vis/near-IR spectra during oxidative metabolic reactions; however, the specific pathways involved in UPE remain poorly understood. Here, we used HL-60 cells, a human...article 2016
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den Ouden, H. (author), Pellis, L. (author), Rutten, G.E.H.M. (author), Geerars-van Vonderen, I.K. (author), Rubingh, C.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Beulens, J.W.J. (author)We aimed to identify metabolites to predict patients’ response to glucose lowering treatment during the first 5 years after detection of type 2 diabetes. Metabolites were measured by GC–MS in baseline samples from 346 screen-detected type 2 diabetes patients in the ADDITION-NL study. The response to treatment with metformin and/or sulphonylurea ...article 2016
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Prodan, A. (author), Imangaliyev, S. (author), Brand, H.S. (author), Rosema, M.N.A. (author), Levin, E. (author), Crielaard, W. (author), Keijser, B.J.F. (author), Veerman, E.C.I. (author)Introduction: Understanding the changes occurring in the oral ecosystem during development of gingivitis could help improve prevention and treatment strategies for oral health. Erythritol is a non-caloric polyol proposed to have beneficial effects on oral health. Objectives: To examine the effect of experimental gingivitis and the effect of...article 2016
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Kortman, G.A.M. (author), Dutilh, B.E. (author), Maathuis, A.J.H. (author), Engelke, U.F. (author), Boekhorst, J. (author), Keegan, K.P. (author), Nielsen, F.G.G. (author), Betley, J. (author), Weir, J.C. (author), Kingsbury, Z. (author), Kluijtmans, L.A.J. (author), Swinkels, D.W. (author), Venema, K. (author), Tjalsma, H. (author)Oral iron administration in African children can increase the risk for infections. However, it remains unclear to what extent supplementary iron affects the intestinal microbiome. We here explored the impact of iron preparations on microbial growth and metabolism in the well-controlled TNO's in vitro model of the large intestine (TIM-2). The...article 2016
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Schoeman, J.C. (author), Harms, A.C. (author), van Wietmarschen, H.A. (author), Vreeken, R.J. (author), Berger, R. (author), Cuppen, B.V.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author), Hankemeier, T. (author)Oxidised lipids, covering enzymatic and auto-oxidation-synthesised mediators, are important signalling metabolites in inflammation while also providing a readout for oxidative stress, both of which are prominent physiological processes in a plethora of diseases. Excretion of these metabolites via urine is enhanced through the phase-II...article 2016
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COordination of Standards in MetabOlomicS (COSMOS): Facilitating integrated metabolomics data accessSalek, R.M. (author), Neumann, S. (author), Schober, D. (author), Hummel, J. (author), Billiau, K. (author), Kopka, J. (author), Correa, E. (author), Reijmers, T. (author), Rosato, A. (author), Tenori, L. (author), Turano, P. (author), Marin, S. (author), Deborde, C. (author), Jacob, D. (author), Rolin, D. (author), Dartigues, B. (author), Conesa, P. (author), Haug, K. (author), Rocca-Serra, P. (author), O’Hagan, S. (author), Hao, J. (author), van Vliet, M. (author), Sysi-Aho, M. (author), Ludwig, C. (author), Bouwman, J. (author), Cascante, M. (author), Ebbels, T. (author), Griffin, J.L. (author), Moing, A. (author), Nikolski, M. (author), Oresic, M. (author), Sansone, S.A. (author), Viant, M.R. (author), Goodacre, R. (author), Günther, U.L. (author), Hankemeier, T. (author), Luchinat, C. (author), Walther, D. (author), Steinbeck, C. (author)Metabolomics has become a crucial phenotyping technique in a range of research fields including medicine, the life sciences, biotechnology and the environmental sciences. This necessitates the transfer of experimental information between research groups, as well as potentially to publishers and funders. After the initial efforts of the...article 2015
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Kaduk, M. (author), Hoefsloot, H.C.J. (author), Vis, D.J. (author), Reijmers, T. (author), van der Greef, J. (author), Smilde, A.K. (author), Hendriks, M.M.W.B. (author)Modern chromatography-based metabolomics measurements generate large amounts of data in the form of abundances of metabolites. An increasingly popular way of representing and analyzing such data is by means of association networks. Ideally, such a network can be interpreted in terms of the underlying biology. A property of chromatography-based...article 2014
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Zha, Y. (author), Westerhuis, J.A. (author), Muilwijk, B. (author), Overkamp, K.M. (author), Nijmeijer, B.M. (author), Coulier, L. (author), Smilde, A.K. (author), Punt, P.J. (author)Background: Inhibitors are formed that reduce the fermentation performance of fermenting yeast during the pretreatment process of lignocellulosic biomass. An exometabolomics approach was applied to systematically identify inhibitors in lignocellulosic biomass hydrolysates.Results: We studied the composition and fermentability of 24 different...article 2014
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Saccenti, E. (author), Tenori, L. (author), Verbruggen, P. (author), Timmerman, M.E. (author), Bouwman, J. (author), van der Greef, J. (author), Luchinat, C. (author), Smilde, A.K. (author)Background: Metabolomics has attracted the interest of the medical community for its potential in predicting early derangements from a healthy to a diseased metabolic phenotype. One key issue is the diversity observed in metabolic profiles of different healthy individuals, commonly attributed to the variation of intrinsic (such as (epi)genetic...article 2014