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Witkamp, R.F. (author), TNO Kwaliteit van Leven (author)This review discusses some of the recent developments in genomics and its current and future relevance for veterinary pharmacology and toxicology. With the rapid progress made in this field several new approaches in pharmacological and toxicological research have developed and drug discovery and drug development strategies have changed...article 2005
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Kummeling, I. (author), Thijs, C. (author), Penders, J. (author), Snijders, B.E.P. (author), Stelma, F. (author), Reimerink, J. (author), Koopmans, M. (author), Dagnelie, P.C. (author), Huber, M. (author), Jansen, M.C.J.F. (author), de Bie, R. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)The aim of the KOALA Birth Cohort Study in the Netherlands is to identify factors that influence the clinical expression of atopic disease with a main focus on lifestyle (e.g., anthroposophy, vaccinations, antibiotics, dietary habits, breastfeeding and breast milk composition, intestinal microflora composition, infections during the first year...article 2005
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Staal, J.B. (author), Rainville, J. (author), Fritz, J. (author), van Mechelen, W. (author), Pransky, G. (author), TNO Kwaliteit van Leven (author)Introduction: There is a body of literature that indicates that physical exercise interventions, with a primary focus on improvement of functioning instead of pain relief, might be effective to stimulate return to work and improve function in workers who are absent from work due to low back pain (LBP). Successful application and implementation...article 2005
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de Raad, J. (author), Nijhuis, F.J.N. (author), Willems, J.H.B.M. (author), TNO Preventie en Gezondheid (author)In 1998, the Royal Netherlands Army introduced a new examination system (abbreviated as BMEKL), which was based on the "workload-capability" model, to replace the old system (abbreviated as PULHEEMS), which focused on diagnosis and was based solely on the detection of diseases and infirmities. To discern differences under operational conditions...article 2005
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Verbeek, J.H. (author), de Boer, A.G. (author), van der Weide, W.E. (author), Piirainen, H. (author), Anema, J.R. (author), van Amstel, R.J. (author), Hartog, F. (author), TNO Kwaliteit van Leven (author)Aims: To develop a questionnaire that measures specific aspects of patient satisfaction with occupational health physicians. Methods: General patient satisfaction questionnaires, a literature survey, and interviews with patients were used. An initial questionnaire was distributed among sick listed patients (n = 432) of occupational physicians (n...article 2005
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van der Greef, J. (author), TNO Kwaliteit van Leven (author)The concept of systems-based strategies in medicine is emerging, with systems pathology guiding an understanding of the multidimensional aspects of disease system fingerprints and systems pharmacology providing insight into dynamic system responses upon (multiple) drug perturbations. Knowledge of the changes of system characteristics during...article 2005
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Wang, M. (author), Lamers, R.J.A.N. (author), Korthout, H.A.A.J. (author), van Nesselrooij, J.H.J. (author), Witkamp, R.F. (author), van der Heijden, R. (author), Voshol, P.J. (author), Havekes, L.M. (author), Verpoorte, R. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)The introduction of the concept of systems biology, enabling the study of living systems from a holistic perspective based on the profiling of a multitude of biochemical components, opens up a unique and novel opportunity to reinvestigate natural products. In the study of their bioactivity, the necessary reductionistic approach on single active...article 2005
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TNO Kwaliteit van Leven (author), Nieuwenhuijsen, K. (author), Verbeek, J.H.A.M. (author), de Boer, A.G.E.M. (author), Blonk, R.W.B. (author), van Dijk, F.J.H. (author)Objective: The objective of this study was to evaluate content validity and predictive validity of 11 performance indicators for the rehabilitation of workers with mental health problems. Research Design and Subjects: Content validity was assessed by experts who evaluated the validity of the performance indicators in 2 Delphi rounds. Predictive...article 2005
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Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Although obesity is an established risk factor for endometrial cancer, evidence linking risk to height, weight change since age 20, and physical activity is limited. In this case-cohort study, 62 573 women from The Netherlands Cohort Study on Diet and Cancer were followed up from 1986 to 1995, and 226 endometrial cancer case patients were...article 2004
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den Hartog, E.A. (author), Lotens, W.A. (author), TNO Technische Menskunde (author)In the Netherlands most murder victims are found 2-24 h after the crime. During this period, body temperature decrease is the most reliable method to estimate the postmortem time (PMT). Recently, two murder cases were analysed in which currently available methods did not provide a sufficiently reliable estimate of the PMT. In both cases a study...article 2004
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Abel, S.M. (author), Crabtree, B. (author), Baranski, J.V. (author), Smith, D.G. (author), Thompson, M.M. (author), Steeneken, H.J.M. (author), Verhave, J.A. (author), Buckey, J.C. (author), Alvarenga, D.L. (author), Comtois, J.M. (author), TNO Technische Menskunde (author)Introduction: Elevated hearing thresholds have been documented in some astronauts after long-term spaceflights although noise levels were lower than those normally associated with noise-induced hearing loss in ground-based operations. The present study was conducted to determine whether prolonged exposure (70 h) to levels (72 dBA) recorded on...article 2004
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de Jong, O.R.W. (author), Hopman-Rock, M. (author), Tak, E.C.M.P. (author), Klazinga, N.S. (author), TNO Preventie en Gezondheid (author)Implementation studies are recommended to assess the feasibility and effectiveness in real-life of programmes which have been tested in randomized controlled trials (RCTs). We report on an implementation study of two evidence-based exercise and health education programmes for older adults with osteoarthritis (OA) of the knee of hip. Three types...article 2004
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Sengupta, S. (author), Toh, S.A. (author), Sellers, L.A. (author), Skepper, J.N. (author), Koolwijk, P. (author), Leung, H.W. (author), Yeung, H.W. (author), Wong, R.N.S. (author), Sasisekharan, R. (author), Fan, T.P.D. (author)Background-Ginseng is a commonly used nutraceutical. Intriguingly, existing literature reports both wound-healing and antitumor effects of ginseng extract through opposing activities on the vascular system. To elucidate this perplexity, we merged a chemical fingerprinting approach with a deconstructional study of the effects of pure molecules...article 2004
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Kerstholt, J.H. (author), Jansen, N.J.M. (author), van Amelsvoort, A.G. (author), Broeders, A.P.A. (author), TNO Technische Menskunde (author)An experiment was conducted to investigate the reliability of voice lineups. More specifically, the experiment was designed to look into the effects of retention interval (an immediate test or after a week), speech duration (30 or 70 s) and acoustic environment (indoors or indoors and outdoors) on speaker identification accuracy. In addition,...article 2004
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van Poppel, M.N.M. (author), Hooftman, W.E. (author), Koes, B.W. (author)Objective. To update the evidence on the effectiveness of lumbar supports, education and exercise in the primary prevention of low back pain at the workplace. Methods. A computerized search for controlled clinical trials published between 1997 and 2002 was conducted, and the methodological quality of the studies was assessed using a criteria...article 2004
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de Maat, M.P.M. (author), Trion, A. (author), TNO Preventie en Gezondheid (author)Purpose of review C-reactive protein (CRP) is consistently associated with cardiovascular disease in prospective and cross-sectional clinical and epidemiological studies. Inflammation is an important mechanism in cardiovascular disease, and the plasma level of CRP is considered to. reflect the inflammatory condition of the patient and/or the...article 2004
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TNO Arbeid (author), Hooftman, W.E. (author), van Poppel, M.N.M. (author), van der Beek, A.J. (author), Bongers, P.M. (author), van Mechelen, W. (author)Gender differences in the prevalence of musculoskeletal complaints might be explained by differences in the effect of exposure to work-related physical and psychosocial risk factors. A systematic review was conducted to examine gender differences in the relations between these risk factors and musculoskeletal complaints. Several electronic...article 2004
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Valk, P.J.L. (author), van Roon, D.B. (author), Simons, M. (author), Rikken, G. (author)Sustained vigilance is required by pilots and crew during flight; therefore, the use of antihistamines with sedating properties is widely prohibited. The purpose of this study was to determine the effects of desloratadine, a long-acting, nonsedating antihistamine, on healthy volunteers placed under conditions of simulated cabin pressure. Methods...article 2004
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TNO Preventie en Gezondheid (author), Forsén, L. (author), Søgaard, A.J. (author), Sandvig, S. (author), Schuller, A. (author), Røed, U. (author), Arstad, C. (author)Objectives: To compare the probability of hip fracture in protected and unprotected falls in a real world setting in nursing homes. Design: Observational study. Setting: Seventeen nursing homes (965 beds) in Norway. Subjects: All residents in the nursing homes with at least one fall during the intervention period. Intervention: Hip protectors...article 2004
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Goede, H.A. (author), Tijssen, S.C.H.A. (author), Schipper, H.J. (author), Warren, N. (author), Oppl, R. (author), Kalberlah, F. (author), van Hemmen, J.J. (author), TNO Voeding (author)This paper describes how default dermal exposure values can be adjusted with modifier values for specific work situations. The work presented here is supplementary to a toolkit developed for the EU RISKOFDERM project. This toolkit is intended for the assessment and management of dermal risks in small and medium sized enterprises. Potential...article 2003