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TNO Defensie en Veiligheid (author), Delleman, N.J. (author), Colaciuri, V. (author), Wiederkehr, E. (author), Valk, P.J.L. (author)This paper reports 2 baseline studies and 1 experiment performed in a confined-space military vehicle concerning the effects on fitness and performance of time in a sitting posture and workstation characteristics. On average physical fitness decreased by slightly more than 10% per hour, the observation performance decreased by ~30% per hour, and...article 2008
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Kerstholt, J.H. (author), Paashuis, R. (author), Sjerps, M. (author), TNO Defensie en Veiligheid (author)As trace evidence is becoming more and more important in legal cases it has to be ascertained that accurate judgments are made. In the present study we investigated how expectations and complexity affect shoe print examinations and to what extent differences exist between beginners and experienced examiners. Twelve examiners assessed similarity...article 2007
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Hettinga, F.J. (author), de Koning, J.J. (author), de Vrijer, A. (author), Wüst, R.C.I. (author), Daanen, H.A.M. (author), Foster, C. (author), TNO Defensie en Veiligheid (author)Time-trial performance deteriorates in the heat. This might potentially be the result of a temperature-induced decrease in gross-efficiency (GE). The effect of high ambient temperature on GE during cycling will be studied, with the intent of determining if a heat-induced change in GE could account for the performance decrements in time trial...article 2007
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Nielen, M.W.F. (author), van Engelen, M.C. (author), Zuiderent, R. (author), Ramaker, R. (author), TNO Kwaliteit van Leven (author)An emerging trend is recognised in hormone and veterinary drug residue analysis from liquid chromatography tandem mass spectrometry (LC/MS/MS) based screening and confirmation towards accurate mass alternatives such as LC coupled with time-of-flight (TOF), Fourier transform ion cyclotron resonance (FTICR) or Fourier transform orbitrap (FT...article 2007
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van der Greef, J. (author), Martin, S. (author), Juhasz, P. (author), Adourian, A. (author), Plasterer, T. (author), Verheij, E.R. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)Systems biology has developed in recent years from a technology-driven enterprise to a new strategic tool in Life Sciences, particularly for innovative drug discovery and drug development. Combining the ultimate in systems phenotyping with in-depth investigations of biomolecular mechanisms will enable a revolution in our understanding of disease...article 2007
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Einhorn, R. (author), van Eekhof, J.A.H. (author), Engelberts, A.C. (author), Groeneveld, Y. (author), Verkerk, P.H. (author), Wit, J.M. (author), TNO Kwaliteit van Leven (author)Background: In the Netherlands, preventive child health service (CHS) screening plays an important role in the early detection of congenital, developmental, physical, and mental disorders. Objective: To obtain insight into the referral patterns of children from CHS to general practitioners and from general practitioners to medical specialists....article 2007
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van Dommelen, P. (author), van Wouwe, J.P. (author), Breuning-Boers, J.M. (author), van Buuren, S. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)Objective: The validity of the rule of thumb that infants may have a weight loss of 10% in the first days after birth is unknown. We assessed the validity of this and other rules to detect breast-fed infants with hypernatraemic dehydration. Design: A reference chart for relative weight change was constructed by the LMS method. The reference...article 2007
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TNO Defensie en Veiligheid (author), Simons, M. (author)Onbehandelde luchtwegobstructie leidt in enkele minuten tot de dood en daarom is adequaat pre-hospitaal luchtwegmanagement noodzakelijk bij ernstig gewonde combat slachtoffers. In de civiele of militaire ziekenhuiswereld is endotracheale intubatie (ETI) in handen van ervaren personeel de 'goud standaard' voor controle over de luchtweg. In de pre...article 2007
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Kennedy, S. (author), Jin, X. (author), Yu, H. (author), Zhong, S. (author), Magill, P. (author), van Vliet, T. (author), Kistemaker, C. (author), Voors, C. (author), Pasman, W. (author), TNO Kwaliteit van Leven (author)A proof-of-concept study to assess the safety and efficacy of a traditional Chinese medicine formula as treatment for primary dysmenorrhea showed no statistically significant benefit over placebo. However, some efficacy parameters suggested possible superiority of the active treatment and so a larger study needs to be performed to determine...article 2006
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van der Greef, J. (author), Hankemeier, T. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)Personalized medicine - defined as customized medical care for each patient's unique condition - in the broader context of personalized health, will make significant strides forward when a systems approach is implemented to achieve the ultimate in disease phenotyping and to create novel therapeutics that address system-wide molecular...article 2006
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Goldbohm, R.A. (author), Tielemans, E.L.J.P. (author), Heederik, D. (author), Rubingh, C.M. (author), Dekkers, S. (author), Willems, M.I. (author), Dinant Kroese, E. (author), TNO Kwaliteit van Leven (author)It is generally recognized that human, epidemiological data, if available, are preferred as the starting point for quantitative risk analysis above the use of data from animal studies. Although methods to obtain proper risk estimates from epidemiological data are available, several impediments prevent their widespread application. These...article 2006
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van Buuren, S. (author), Boshuizen, H.C. (author), Reijneveld, S.A. (author), TNO Kwaliteit van Leven (author)Background. Guidelines for screening and subsequent treatment of hypertension vary widely between countries. Part of this variation can be attributed to systematic differences between populations, but little is known about the way in which guidelines should be targeted to the population of interest. Optimal guidelines should have high yield and...article 2006
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Heerdink-Obenhuijsen, N. (author), Kamphuis, M. (author), Fleuren, M.A.H. (author), van Velzen-Mol, H.W.M. (author), de Wilde, J.A. (author), TNO Kwaliteit van Leven (author)The Dutch Child Health Care guideline on the early detection of congenital heart disease was developed according to the principles for evidence-based guideline development and contains recommendations for the conduct of the examination during routine check-ups and for referral criteria. Most congenital heart diseases can be detected in the first...article 2006
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Reffeltrath, P.A. (author), TNO Defensie en Veiligheid (author)Background: Helicopter pilots are often exposed to periods of high heat strain, especially when wearing survival suits. Therefore, a prototype of a ventilated vest was evaluated on its capability to reduce the heat strain of helicopter pilots during a 2-h simulated flight. Hypothesis: It was hypothesized that the ventilated vest would reduce...article 2006
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van Es, E.M. (author), van der Loo, H. (author), TNO Defensie en Veiligheid (author)'Beter hard en hevig' kopte Intermediair van 28 september 2006. Het betrof de steeds sterker wordende aanwijzingen, dat kortdurende, hoogintensieve inspanning net zo effectief kan zijn voor het verbeteren van de fysieke fitheid als langdurige inspanning op een matige intensiteit. Bij TNO in Soesterberg is de afgelopen maanden onderzoek gedaan...article 2006
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Chang, W.T. (author), Thissen, U. (author), Ehlert, K.A. (author), Koek, M.M. (author), Jellema, R.H. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author), TNO Kwaliteit van Leven TNO Voeding (author)Metabolite profiling in combination with multivariate statistics is a sophisticated method for quality assessment of natural products. For the development of a quality control strategy in Traditional Chinese Medicine (TCM), we have measured the metabolite fingerprints of Rehmannia glutinosa by GC-MS. Plants were grown under different climate and...article 2006
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Reijneveld, S.A. (author), Harland, P. (author), Brugman, E. (author), Verhulst, F.C. (author), Verloove-Vanhorick, S.P. (author)Background This study aims to examine a) the prevalence of psychosocial problems and b) the association between parent-reported problems and the identification by doctors and nurses (child health professionals, CHP) working in preventive child health care, among immigrant and non-immigrant children. Methods CHPs examined 4,098 children aged 5...article 2005
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Stolker, A.A.M. (author), Brinkman, U.A.T. (author), TNO Kwaliteit van Leven (author)After a brief introduction into the field of veterinary drugs and growth-promoting agents, the most important EU regulations and directives for the inspection of food-producing animals and animal products regarding the residue control of these substances are presented and discussed. Main attention in the review is on the methods of analysis in...article 2005
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van Dommelen, P. (author), van Buuren, S. (author), Zandwijken, G.R.J. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)The goal of this study is to assess whether a growth curve model approach will lead to a more precise detection of Turner sydnrome (TS) than conventional referral criteria for growth monitoring. The Jenss-Bayley growth curve model was used to describe the process of growth over time. A new screening rule is defined on the parameters of this...article 2005
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van Amstel, R.J. (author), Anema, J.R. (author), Jettinghoff, K. (author), Verbeek, J.H. (author), Nauta, A.P. (author), van Putten, D.J. (author), TNO Kwaliteit van Leven (author)Objective. To evaluate whether regional projects for collaboration between general practitioners (GPs) and occupational physicians (OPs) improved the quality of their social medical guidance (SMG) and the satisfaction of their patients. Design. Evaluation study with before and after measurements with respect to the same GPs and OPs. Method....article 2005