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den Ouden, H. (author), Pellis, L. (author), Rutten, G.E.H.M. (author), Geerars-van Vonderen, I.K. (author), Rubingh, C.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Beulens, J.W.J. (author)We aimed to identify metabolites to predict patients’ response to glucose lowering treatment during the first 5 years after detection of type 2 diabetes. Metabolites were measured by GC–MS in baseline samples from 346 screen-detected type 2 diabetes patients in the ADDITION-NL study. The response to treatment with metformin and/or sulphonylurea ...article 2016
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Stegehuis, P.L. (author), Boogerd, L.S.F. (author), Inderson, A. (author), Veenendaal, R.A. (author), Bonsing, B.A. (author), Amelink, A. (author), Vahrmeijer, A.L. (author), Dijkstra, J. (author), Robinson, D.J. (author)EUS-FNA can be used for pathological confirmation of a suspicious pancreatic mass. However, performance depends on an on-site cytologist and time between punction and final pathology results can be long. SFR spectroscopy is capable of extracting biologically relevant parameters (e.g. oxygenation and blood volume) in real-time from a very small...conference paper 2016
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He, M. (author), Sun, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), van Wijk, R. (author), Wang, Z. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author)To present the possibilities pertaining to linking ultra-weak photon emission (UPE) with Chinese medicine-based diagnostics principles, we conducted a review of Chinese literature regarding UPE with respect to a systems view of diagnostics. Data were summarized from human clinical studies and animal models published from 1979 through 1998. The...article 2016
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Groeneweg, J. (author), ter Mors, E. (author)Risk-taking behavior is an important contributing human factor to incidents and notoriously difficult to influence. A basic premise of approaches to improving safety by putting in extra levels of protection (e.g. the Swiss cheese model) is that providing information on the number of layers in place does not influence the risk-taking behavior of...conference paper 2016
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Deurloo, J.A. (author), Verkerk, P.H. (author)Objectives: Over the years, there has been much debate about the desirability and efficacy of screening for adolescent idiopathic scoliosis. To analyse the current evidence from a public health point of view a renewed evaluation of the literature was performed. Study design: Literature review. Methods: We performed two literature searches: from...article 2015
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van der Greef, J. (author), Wietmarschen, H. (author), Schroën, Y. (author), Babouraj, N. (author), Trousselard, M. (author)Background: The current health care system faces increasing costs and demands while the presence of chronic conditions in the general populations is rising. A shift from disease fighting toward health promotion is needed to prevent these conditions and empower people to work on their own health. In the Military setting, health promotion is...article 2015
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Wagner, A. (author), Cohen, N. (author), Kelder, T. (author), Amit, U. (author), Liebman, E. (author), Steinberg, D.M. (author), Radonjic, M. (author), Ruppin, E. (author)High-throughput omics have proven invaluable in studying human disease, and yet day-to-day clinical practice still relies on physiological, non-omic markers. The metabolic syndrome, for example, is diagnosed and monitored by blood and urine indices such as blood cholesterol levels. Nevertheless, the association between the molecular and the...article 2015
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van de Pas, N.C.A. (author), Rullmann, J.A.C. (author), Woutersen, R.A. (author), van Ommen, B. (author), Rietjens, I.M.C.M. (author), de Graaf, A.A. (author)We used a previously developed physiologically based kinetic (PBK) model to analyze the effect of individual variations in metabolism and transport of cholesterol on pravastatin response. The PBK model is based on kinetic expressions for 21 reactions that interconnect eight different body cholesterol pools including plasma HDL and non-HDL...article 2014
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- Liping, Qu (author), Wenjun, Zou (author), Zhenxiang, Zhou (author), Tingmo, Zhang (author), van der Greef, J. (author), Wang, M. (author) article 2014
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Kostewicz, E.S. (author), Abrahamsson, B. (author), Brewster, M. (author), Brouwers, J. (author), Butler, J. (author), Carlert, S. (author), Dickinson, P.A. (author), Dressman, J. (author), Holm, R. (author), Klein, S. (author), Mann, J. (author), McAllister, M. (author), Minekus, M. (author), Muenster, U. (author), Müllertz, A. (author), Verwei, M. (author), Vertzoni, M. (author), Weitschies, W. (author), Augustijns, P. (author)Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is critical to efficient drug development. Traditionally, in vitro evaluation of oral drug formulations has focused on disintegration and dissolution testing for quality control (QC) purposes. The connection with in vivo biopharmaceutical performance has...article 2014
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Akhnikh, S. (author), Engelberts, A.C. (author), van Sleuwen, B.E. (author), L’ Hoir, M.P. (author), Benninga, M.A. (author)Excessive crying, often described as infantile colic, is the cause of 10% to 20% of all early pediatrician visits of infants aged 2 weeks to 3 months. Although usually benign and selflimiting, excessive crying is associated with parental exhaustion and stress. However, and underlying organic cause is found in less than 5% of these infants. In...article 2014
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van Buuren, S. (author), Perenboom, R.J.M. (author)There are very few norms to evaluate and monitor the health and functioning of the elderly. This paper proposes a compact spatial representation of 25 health measurements of European citizens older than 50 years. Data from 44,285 unique individuals were obtained from the EU-wide Survey of Health, Ageing and Retirement in Europe(SHARE) data...article 2014
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Stege, J.P. (author), Fleuren, M.A.H. (author), van der Knaap, E.T.W. (author), Stubbe, J.H. (author)Since 2004, there have been several initiatives regarding the development of a digital Sport Medical Record (SMD). Interviews with the Netherlands Association of Sports Medicine (VSG) show that there are particular problems with commissioning of the digital SMD. During spring 2012, two focus group interviews with sports physicians were conducted...article 2013
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van Wietmarschen, H.A. (author), der Greef, J.V. (author), Schroën, Y. (author), Wang, M. (author)Ethnopharmacological relevance Rehmannia Six Formula (R6, Chinese name is Liu Wei Di Huang Wan) is one of the most important classic Chinese medicine formula used to treat metabolic disorders related to aging. It was first reported in the Chinese medicine book titled 'Xiao Er Yao Zheng Zhi Jue by Qian Yi' (Chinese Song dynasty: 1035-1117). In...article 2013
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- Cesuroglu, T. (author), van Ommen, B. (author), Malats, N. (author), Sudbrak, R. (author), Lehrach, H. (author), Brand, A. (author) article 2012
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van Gool, A.J. (author), Hendrickson, R.C. (author)Cerebrospinal fluid (CSF) can be considered the most promising biosample for the discovery and analysis of biomarkers in neuroscience, an area of great medical need. CSF is a body fluid that surrounds the brain and provides a rich pool of biochemical markers, both proteomic and metabolomic, that reflect the state of neurological processes. Such...article 2012
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de Hollander, E.L. (author), Zwart, L. (author), de Vries, S.I. (author), Wendel-Vos, W. (author)Objective: To examine whether the "Short QUestionnaire to ASsess Health-enhancing physical activity" (SQUASH) and the "Injuries and Physical Activity in the Netherlands" questionnaire ("Ongevallen en Bewegen in Nederland," OBiN) were valid in assessing adherence to physical activity (PA) guidelines. Study Design and Setting: Participants (N =...article 2012
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Hague Centre for Strategic Studies Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek (author)Over the past five years, the pharmaceutical supply chain has grown increasingly unreliable. According to the US Food and Drug Administration (FDA), the figure of drug shortages has tripled between 2006 and 2010 (see Figure 1 and Figure 21). In 2010 alone 211 cases were recorded, while in 2011 up to 89 cases were recorded as early as March.2...report 2012
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van Beijsterveldt, A.M.C. (author), Krist, M.R. (author), Schmikli, S.L. (author), Stubbe, J.H. (author), de Wit, G.A. (author), Inklaar, H. (author), van de Port, I.G.L. (author), Backx, F.J.G. (author)Background and aims Approximately 16% of all sports injuries in the Netherlands are caused by outdoor soccer. A cluster-randomised controlled trial has been designed to investigate the effectiveness and cost-effectiveness of an injury prevention programme ('The11') for male amateur soccer players. The injury prevention programme The11, developed...article 2011
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van der Greef, J. (author), van Wietmarschen, H. (author), Schroën, J. (author), Wang, M. (author), Hankemeier, T. (author), Xu, G. (author), TNO Kwaliteit van Leven (author)Innovative systems approaches to develop medicine and health care are emerging from the integration of Chinese and Western medicine strategies, philosophies and practices. The two medical systems are highly complementary as the reductionist aspects of Western medicine are favourable in acute disease situations and the holistic aspects of Chinese...article 2010