Searched for: subject%3A%22Medicine%22
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Eekhout, I. (author), van Buuren, S. (author), Visser, B. (author), Bink, M.C.A.M. (author), Huisman, A. (author)
Intensive longitudinal data can be used to explore important associations and patterns between various types of inputs and outcomes. Nonlinear relations and irregular measurement occasions can pose problems to develop an accurate model for these kinds of data. This paper focuses on the development, fitting and evaluation of a prediction model...
article 2023
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de Frel, D.L. (author), Assendelft, W.J.J. (author), Hondmann, S. (author), Janssen, V.R. (author), Molema, J.J.W. (author), Trines, S.A. (author), de Vries, I.A.C. (author), Schalij, M.J. (author), Atsma, D.E. (author)
Suboptimal diet is a major modifiable risk factor in cardiovascular disease. Governments, individuals, educational institutes, healthcare facilities and the industry all share the responsibility to improve dietary habits. Healthcare facilities in particular present a unique opportunity to convey the importance of healthy nutrition to patients,...
article 2022
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Vossen, E. (author), van der Gulden, J.W.J. (author), van Genabeek, J. (author), Schaap, R. (author), Anema, J.R. (author), Schaafsma, F.G. (author)
Background. For working patients with a lower socioeconomic position, health complaints often result from a combination of problems on multiple life domains. To prevent long-term health complaints and absence from work, it is crucial for general and occupational health professionals to adopt a broad perspective on health and to collaborate when...
article 2022
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Suchowerska, A.K. (author), Stokman, G. (author), Palmer, J.T. (author), Coghlan, P.A. (author), Pieterman, E.J. (author), Keijzer, N. (author), Lambert, G. (author), Chemello, K. (author), Jaafar, A.K. (author), Parmar, J. (author), Yan, L. (author), Tong, Y. (author), Mu, L. (author), Princen, H.M.G. (author), Bonnar, J. (author), Evison, B.J. (author)
Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor (LDLR) and sending the receptor for lysosomal degradation. As the interaction promotes elevated plasma LDL-C levels, and therefore a predisposition to...
article 2022
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van de Ven, D. (author), Robroek, S.J. (author), Oude Hengel, K.M. (author), van Zon, S.K. (author), Brouwer, S. (author), Ots, P. (author), Burdorf, A. (author), Schuring, M. (author)
Objectives: This study assessed the associations of (1) within-individual improvements and (2) within-individual deteriorations in working conditions, health behaviour and body mass index (BMI) with changes in work ability and self-rated health among workers. Design: Prospective cohort study. Setting: The Netherlands. Participants: Persons in...
article 2022
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Savage, M.O. (author), Fernandez-Luque, L. (author), Graham, S. (author), van Dommelen, P. (author), Araujo, M. (author), de Arriba, A. (author), Koledova, E. (author)
Pediatric growth hormone (GH) deficiency is a licensed indication for replacement therapy with recombinant human growth hormone (r-hGH). Treatment, consisting of daily subcutaneous injections, extends from the time of diagnosis until cessation of linear growth at completion of puberty. Suboptimal adherence to r-hGH therapy is common and has been...
article 2022
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Morris, N.B. (author), Pijl, J.F. (author), Morabito, M. (author), Messeri, A. (author), Levi, M. (author), Ioannou, L.G. (author), Ciuha, U. (author), Pogacar, T. (author), Kajfez Bogataj, L. (author), Kingma, B.R.M. (author), Casanueva, A. (author), Kotlarski, S. (author), Spirig, C. (author), Foter, J. (author), Havenith, G. (author), Sotto Mayor, T. (author), Flouris, A.D. (author), Nybo, L. (author)
Objectives: To provide perspectives from the HEAT-SHIELD project (www.heat-shield.eu): a multi-national, inter-sectoral, and cross-disciplinary initiative, incorporating twenty European research institutions, as well as occupational health and industrial partners, on solutions to combat negative health and productivity effects caused by working...
article 2021
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de Hoogh, I.M. (author), Oosterman, J.E. (author), Otten, W. (author), Krijger, A.M. (author), Berbée-Zadelaar, S. (author), Pasman, W.J. (author), van Ommen, B. (author), Pijl, H. (author), Wopereis, S. (author)
Although lifestyle interventions can lead to diabetes remission, it is unclear to what extent type 2 diabetes (T2D) remission alters or improves the underlying pathophysiology of the disease. Here, we assess the effects of a lifestyle intervention on T2D reversal or remission and the effects on the underlying pathology. In a Dutch primary care...
article 2021
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de Kock, C.A. (author), Lucassen, P.L. (author), Akkermans, R.P. (author), Knottnerus, J.A. (author), Buijs, P.C. (author), Steenbeek, R. (author), Lagro-Janssen, A.L. (author)
Background. Perception by workers of their health problems as work-related is possibly associated with sickness absence (SA). The aim of this study was to to study the relationship between perceived work-relatedness of health problems and SA among workers who visit their GP, taking the influence of other potential determinants into account and...
article 2020
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Simons, R. (author), Maire, R. (author)
Recommendations. It is recommended that all aircrew, especially those over the age of 40 years, should be periodically screened for cardiovascular risk using a resting ECG and risk estimating calculators that are representative and appropriate for the population to screen and provide non-fatal and fatal endpoints. Pilots with an elevated CVD...
article 2020
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Sewell, F. (author), Strupp, C. (author), van der Laan, J.W. (author), Wolf, D.C. (author), Wolterink, G. (author), Woutersen, R. (author), Zvonar, Z. (author), Heusinkveld, H. (author), Braakhuis, H. (author)
Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies. However, these involve the use of large numbers of animals and the relevance of their predictive power and results has been scientifically challenged. With increased availability of innovative...
article 2020
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Alligier, M. (author), Barrès, R. (author), Blaak, E.E. (author), Boirie, Y. (author), Bouwman, J. (author), Brunault, P. (author), Campbell, K. (author), Clément, K. (author), Farooqi, I.S. (author), Farpour-Lambert, N.J. (author), Frühbeck, G. (author), Goossens, G.H. (author), Hager, J. (author), Halford, J.C.G. (author), Hauner, H. (author), Jacobi, D. (author), Julia, C. (author), Langin, D. (author), Natali, A. (author), Neovius, M. (author), Oppert, J.M. (author), Pagotto, U. (author), Palmeira, A.L. (author), Roche, H. (author), Rydén, M. (author), Scheen, A.J. (author), Simon, C. (author), Sorensen, T.I.A. (author), Tappy, L. (author), Yki-Järvinen, H. (author), Ziegler, O. (author), Laville, M. (author)
Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous...
article 2020
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Bobeldijk, I. (author), van Dijken, p. (author), van Drumpt, S. (author), van de Sandt, H. (author), Vaes, W. (author)
Our growing understanding of pathological processes is enabling the development of drugs that are ‘tailored’ to specific patients or groups of patients, and hence far more effective. At the same time, developing tomorrow’s medicine is prohibitively expensive, time-consuming and risky. New partnerships and technological developments to speed up...
other 2020
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Tans, R. (author), Verschuren, L. (author), Wessels, H.J.C.T. (author), Bakker, S.J.L. (author), Tack, C.J. (author), Gloerich, J. (author), van Gool, A.J. (author)
Introduction: The onset of type 2 diabetes mellitus (T2DM) is strongly associated with obesity and subsequent perturbations in immuno-metabolic responses. To understand the complexity of these systemic changes and better monitor the health status of people at risk, validated clinical biomarkers are needed. Omics technologies are increasingly...
article 2019
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Swuste, P. (author), Zwaard, W. (author), Groeneweg, J. (author), Guldenmund, F. (author)
The origin of occupational safety, as an area of main interest of the government, the industry, the unions, and scientists starts in the Netherlands at the end of the 19th century. Roughly in the same period occupational medicine becomes a separate domain. Only just after World War II are safety professionals organised in associations. Starting...
article 2019
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de Kock, C. (author), Noben, C. (author), Lagro-Janssen, A. (author), Lucassen, P. (author), Steenbeek, R. (author)
Background Assessing the cost effectiveness of training aimed at increasing general practitioners’ (GP) work awareness and patients’ work-related self-efficacy and quality of life. Methods A cluster randomized controlled trial in twenty-six GP practices in the southeast of the Netherlands with 32 participating GPs. GPs working in an intervention...
article 2019
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Fu, J. (author), van Wietmarschen, H.A. (author), van der Kooij, A. (author), Cuppen, B.V.J. (author), Schroën, Y. (author), Marijnissen, A.K. (author), Meulman, J.J. (author), Lafeber, F.P.J.G. (author), van der Greef, J. (author)
Introduction: Biological therapies have greatly improved the treatment efficacy in rheumatoid arthritis (RA). However, in clinical practice a significant proportion of patients experience an inadequate response to treatment. The aim of this study is to classify responding and non-responding rheumatoid arthritis patients treated with biological...
article 2018
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Sun, M. (author), Chang, W.T. (author), van Wijk, E. (author), He, M. (author), Koval, S. (author), Lin, M.K. (author), Van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author), Wang, M. (author)
Based on the traditional Chinese medicine theory, the Chinese pharmacopeia assigns a therapeutic description of “taste” to all herbs; thus, an herb's “taste” is valued in traditional Chinese medicine as a major ethnopharmacological category and reflects the herb's therapeutic properties. These properties guide the practitioner with respect to...
article 2017
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Sun, M. (author), van Wijk, E. (author), Koval, S. (author), van Wijk, R. (author), He, M. (author), Wang, M. (author), Hankemeier, T. (author), van der Greef, J. (author)
The global prevalence of type 2 diabetes is estimated to reach 4.4% by 2030, placing a significant burden on our healthcare system. Therefore, the ability to identify patients in early stages of the disease is essential for both prevention and effective management, and diagnostic methods based on traditional Chinese medicine (TCM) may be...
article 2017
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Sun, M. (author), van Wijk, R. (author), van Wijk, E. (author), Wang, M. (author), van Wietmarschen, H. (author), Hankemeier, T. (author), van der Greef, J. (author)
In Chinese medicine, raw herbal materials are used in processed and unprocessed forms aiming to meet the different requirements of clinical practice. To assure the chemical quality and therapeutic properties of the herbs, fast and integrated systematic assays are required. So far, such assays have not been established. Delayed luminescence (DL)...
article 2016
Searched for: subject%3A%22Medicine%22
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