Searched for: subject:"Maturity"
(1 - 20 of 28)

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Holmgren, G. (author), Ulfenborg, B. (author), Asplund, A. (author), Toet, K. (author), Andersson, C.X. (author), Hammarstedt, A. (author), Hanemaaijer, J.R.O. (author), Küppers-Munther, B. (author), Synnergren, J. (author)
There is a strong anticipated future for human induced pluripotent stem cell-derived hepatocytes (hiPS-HEP), but so far, their use has been limited due to insufficient functionality. We investigated the potential of hiPS-HEP as an in vitro model for metabolic diseases by combining transcriptomics with multiple functional assays. The...
article 2020
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Ortt, R. (author), Stolwijk, C.C.M. (author), Punter, M. (author)
Purpose: The purpose of this paper is to introduce, summarize and combine the results of 11 articles in a special issue on the implementation of Industry 4.0. Industry 4.0 emerged as a phenomenon about a decade ago. That is why, it is interesting now to explore the implementation of the concept. In doing so, four research questions are addressed...
article 2020
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Zwetsloot, G.I.J.M. (author), van Middelaar, J. (author), van der Beek, D. (author)
article 2020
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Poort, J.P. (author), Shoeibi Omrani, P.S. (author), Vecchia, A.L. (author)
The production optimization of mature gas fields is severely complicated by the occurrence of certain undesired well events such as salt precipitation, liquid loading, or gas/water coning. Learning from production data of periods in which such events have taken place could help operators improve the process optimization. However, due to the...
conference paper 2020
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Jansen-Ferdinandus, G.R. (author), Buiel, E.F.T. (author), Meiler, P.P. (author), Verburgh, T. (author)
The increasing labour shortage of skilled ICT personnel forces SOC and CSIRT organisations to prioritize the services they offer and optimise their workforce development strategies. Our review of currently available frameworks shows that there is no single framework that provides a complete solution to identify the required competencies of SOC...
report 2018
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Preenen, P.T.Y. (author), Howaldt, J. (author), Oeij, P.R.A. (author), Dhondt, S. (author), Kraan, K.O. (author), Jansen, E. (author)
Although the positive impact of job autonomy has been widely shown for individual-level employee outcomes, research on job autonomy and company-level outcomes has been surprisingly scarce. Therefore, among 3,311 companies in the Netherlands, we investigate the relationship between employees' job autonomy and company performance growth (revenue,...
article 2016
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Seyfang, B. (author), Aigner, T. (author), Munsterman, D.K. (author), Irmen, A. (author)
Hydrocarbon provinces require a high level of geological understanding in order to extend the lives of producing fields, to replace reserves through smaller targets and to reduce the risks of exploring for more and more subtle hydrocarbon traps. Despite a large number of existing wells in the area studied in this paper, the depositional...
article 2016
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Hofman, W.J. (author)
Supply - and logistics innovations require data of different, heterogeneous sources. Supply chain resilience for instance requires visibility of goods flows and data of planned infrastructure maintenance and unforeseen accidents or incidents that may cause delays. Technically, there are different ways to share this data, e.g. the messaging...
conference paper 2016
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Verhoosel, J. (author)
This paper describes the results of a maturity assessment of a set of generic building blocks for public administrations in the EU. In the European e-SENS project, various generic building blocks are developed, such as eID, eSignature, eDelivery and eDocument building blocks. They should be used by all EU administrations when they are...
conference paper 2014
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van Buuren, S. (author), Perenboom, R. (author)
There are very few norms to evaluate and monitor the health and functioning of the elderly. This paper proposes a compact spatial representation of 25 health measurements of European citizens older than 50 years. Data from 44,285 unique individuals were obtained from the EU-wide Survey of Health, Ageing and Retirement in Europe(SHARE) data...
article 2014
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van Berlo, L.A.H.M. (author), Dijkmans, T.J.A. (author), Hendriks, H. (author), Spekkink, D. (author), Pel, W. (author)
In 2009 a “BIM QuickScan” for benchmarking BIM performance was created in the Netherlands (Sebastian, Berlo 2010). This instrument aims to provide insight into the current BIM performance of a company. The benchmarking instrument combines quantitative and qualitative assessments of the ‘hard’ and ‘soft’ aspects of BIM. The use of this instrument...
conference paper 2012
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Beker-van Woudenberg, A.C.R.L. (author), Gröllers-Mulderij, M. (author), Snel, C. (author), Jeurissen, N. (author), Stierum, R. (author), Wolterbeek, A. (author)
Reproductive toxicity testing according to the present guidelines requires a high number of animals. Therefore, the development of alternative in vitro methods is urgently required. The aim of the present study was to investigate the applicability domain of the bovine oocyte in vitro maturation assay (bIVM) to study female reproductive...
article 2012
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Sebastian, R. (author), van Berlo, L. (author), TNO Bouw en Ondergrond (author)
Building information modelling (BIM) is becoming more and more important to manage complex communication and information sharing processes in collaborative building projects. A growing number of design, engineering and construction firms have made attempts to adopt BIM to enhance their services and products. However, there remain many...
article 2010
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Boele, L.C.L. (author), Bajramovic, J.J. (author), de Vries, A.M.M.B.C. (author), Voskamp-Visser, I.A.I. (author), Kaman, W.E. (author), van der Kleij, D. (author), TNO Defensie en Veiligheid (author)
Activation of pattern recognition receptors such as Toll-like receptors (TLRs) by pathogens leads to activation and maturation of dendritic cells (DC), which orchestrate the development of the adaptive immune response. To create an overview of the effects of a broad range of pathogenic bacteria, their capacity to activate TLRs and to affect DC...
article 2009
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van Wees, J.-D. (author), Juez-Larre, J. (author), Mijnlieff, H. (author), Kronimus, A. (author), van Gessel, S. (author), Kramers, L. (author), Obdam, A. (author), Verweij, H. (author), Bonté, D. (author), TNO Bouw en Ondergrond (author)
In the recent years the use of geothermal energy through implementation of low enthalpy geothermal production systems for both electricity and heating have been growing rapidly in north-western Europe. Geothermal exploration and production takes largely place in sedimentary basins at depths from 2 to 5 km. Geothermal activities can take...
conference paper 2009
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Wich, S.A. (author), Steenbeek, R. (author), Sterck, E.H.M. (author), Korstjens, A.H. (author), Willems, E.P. (author), van Schaik, C.P. (author), TNO Kwaliteit van Leven (author)
Life history data from wild primate populations are necessary to explain variation in primate social systems and explain differences between primates and other mammals. Here we report life history data from a 12.5-year study on wild Thomas langurs. Mean age at first reproduction was 5.4 years and the sex ratio at birth was even. The mean...
article 2007
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van Wijk, F. (author), Knippels, L. (author), TNO Kwaliteit van Leven (author)
Immediately after birth the mucosa of the gastrointestinal tract, which represents the greatest body surface area exposed to the outside environment, is confronted with a large variety of foreign antigens. The immune system of the intestine now has to meet the task of discriminating between pathogens and harmless antigens, such as food proteins...
article 2007
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Lehé, C.L. (author), Jacobs, J.J.L. (author), Hua, C.M. (author), Courtellemont, P. (author), Elliott, G.R. (author), Das, P.K. (author), TNO Defensie en Veiligheid (author)
The accelerated migration of Langerhans cells (LCs) out of the epidermis and up-regulation of maturation markers, upon treatment with subtoxic concentrations of chemicals, were used as the criteria to determine the potential of allergenic chemicals capable of inducing a hapten-specific delayed-type hypersensitivity reaction. Here we report the...
article 2006
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Jacobs, J.J.L. (author), Lehé, C.L. (author), Hasegawa, H. (author), Elliott, G.R. (author), Das, P.K. (author), TNO Defensie en Veiligheid (author)
Skin irritants and contact allergens reduce the number of Langerhans cells (LCs). It has been assumed that this reduction is due their migration to the draining lymph node (LN) for initiating immune sensitization in a host. Skin irritation, however, as opposed to contact allergy is not considered to be an immunological disease. Nevertheless,...
article 2006
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Lin, Y.L. (author), Brama, P.A.J. (author), Kiers, G.H. (author), de Groot, J. (author), van Weeren, P.R. (author), TNO Preventie en Gezondheid (author)
Objective - To quantify and compare biochemical characteristics of the extracellular matrix (ECM) of specimens harvested from tensional and compressive regions of the superficial digital flexor tendon (SDFT) of horses in age classes that include neonates to mature horses. Sample population - Tendon specimens were collected on postmortem...
article 2005
Searched for: subject:"Maturity"
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