Searched for: subject%3A%22Matrix%255C%2BMetalloproteinase%255C%2B9%22
(1 - 18 of 18)
document
van den Borne, S.W.M. (author), Cleutjens, J.P.M. (author), Hanemaaijer, R. (author), Creemers, E.E. (author), Smits, J.F.M. (author), Daemen, M.J.A.P. (author), Blankesteijn, W.M. (author), TNO Kwaliteit van Leven (author)
Background: Infarct rupture is a usually fatal complication of myocardial infarction (MI), for which no molecular mechanism has been described in humans. Experimental evidence in mouse models suggests that the degradation of the extracellular matrix by matrix metalloproteinases (MMPs) plays an important role in infarct rupture. The present study...
article 2009
document
Stone, O.A. (author), Richer, C. (author), Emanueli, C. (author), van Weel, V. (author), Quax, P.H.A. (author), Katare, R. (author), Kraenkel, N. (author), Campagnolo, P. (author), Barcelos, L.S. (author), Siragusa, M. (author), Sala-Newby, G.B. (author), Baldessari, D. (author), Mione, M. (author), Vincent, M.P. (author), Benest, A.V. (author), Al Haj Zen, A. (author), Gonzalez, J. (author), Bates, D.O. (author), Alhenc-Gelas, F. (author), Madeddu, P. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE : Human Tissue Kallikrein (hKLK1) overexpression promotes an enduring neovascularization of ischemic tissue, yet the cellular mechanisms of hKLK1-induced arteriogenesis remain unknown. Furthermore, no previous study has compared the angiogenic potency of hKLK1, with its loss of function polymorphic variant, rs5515 (R53H), which...
article 2009
document
TNO Kwaliteit van Leven (author), Lindeman, J.H.N. (author), Abdul-Hussien, H. (author), van Bockel, J.H. (author), Wolterbeek, R. (author), Kleemann, R. (author)
Background-Doxycycline has been shown to effectively inhibit aneurysm formation in animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix metalloproteinase-9 inhibition, such an effect is unclear in human studies. We reevaluated the effect of doxycycline on aortic wall protease content in a inical trial and found...
article 2009
document
Fabriek, B.O. (author), Møller, H.J. (author), Vloet, R.P.M. (author), van Winsen, L.M. (author), Hanemaaijer, R. (author), Teunissen, C.E. (author), Uitdehaag, B.M.J. (author), van den Berg, T.K. (author), Dijkstra, C.D. (author), TNO Kwaliteit van Leven (author)
The scavenger receptor CD163 is selectively expressed on tissue macrophages and human monocytes. CD163 has been implicated to play a role in the clearance of hemoglobin and in the regulation of cytokine production by macrophages. Membrane CD163 can be cleaved by matrix metalloproteinases (MMP) resulting in soluble CD163 (sCD163). In the present...
article 2007
document
Kubben, F.J.G.M. (author), Sier, C.F.M. (author), Schram, M. (author), Witte, T.A.M.C. (author), Veenendaal, R.A. (author), van Duijn, W. (author), Verheijen, J.H. (author), Hanemaaijer, R. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author), TNO Kwaliteit van Leven (author)
Background: Helicobacter pylori gastritis is recognized as an important pathogenetic factor in peptic ulcer disease and gastric carcinogenesis, and is accompanied by strongly enhanced gastric mucosal matrix metalloproteinase-9 (MMP-9) levels. Aim: This study was performed to investigate whether H. pylori-affected gastric mucosal MMP-2 and MMP-9...
article 2007
document
Beklen, A. (author), Tüter, G. (author), Sorsa, T. (author), Hanemaaijer, R. (author), Virtanen, I. (author), Tervahartiala, T. (author), Konttinen, Y.T. (author)
Activated matrix metalloproteinase-3 (MMP-3) can contribute to periodontal ligament destruction in adult periodontitis. Since MMP-3 has been reported to activate proMMP-8 and -9, it was speculated that gingival tissue fibroblast-derived MMP-3 might, in periodontitis, be responsible for activation of gingival crevicular fluid (GCF) neutrophil...
article 2006
document
Bildt, M.M. (author), Snoek-van Beurden, A.M.P. (author), de Groot, J. (author), van El, B. (author), Kuijpers-Jagtman, A.M. (author), van den Hoff, J.W. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Background and Objective: The purpose of this study was to investigate the effects of chemically modified tetracyclines (CMTs) on the production of gelatinases [matrix metalloproteinase (MMP)-2 and -9] by human periodontal ligament (PDL) cells, and on the activity of recombinant gelatinases. Material and Methods: Human PDL cells were cultured...
article 2006
document
TNO Kwaliteit van Leven (author), Sluijter, J.P.G. (author), Pulskens, W.P.C. (author), Schoneveld, A.H. (author), Velema, E. (author), Strijder, C.F. (author), Moll, F. (author), de Vries, J.P. (author), Verheijen, J. (author), Hanemaaijer, R. (author), de Kleijn, D.P.V. (author), Pasterkamp, G. (author)
Background and Purpose - We studied matrix metalloproteinases (MMP) 2, 8, and 9 and extracellular matrix metalloproteinase inducer (EMMPRIN) levels in relation to carotid atherosclerotic plaque characteristics. Methods - Carotid atherosclerotic plaques (n=150) were stained and analyzed for the presence of collagen, smooth muscle cell (SMC), and...
article 2006
document
TNO Preventie en Gezondheid (author), Vernooy, J.H.J. (author), Lindeman, J.H.N. (author), Jacobs, J.A. (author), Hanemaaijer, R. (author), Wouters, E.F.M. (author)
Background: The increased expression of matrix metalloproteinases (MMPs) is considered to be a key factor in the development of COPD. Net MMP activity represents a tightly regulated process, which is not addressed by conventional investigation methods such as messenger RNA or protein expression. Yet, quantitative data on MMP activity in the...
article 2004
document
Gaubius Instituut TNO (author), Tchetverikov, I. (author), Ronday, H.K. (author), van El, B. (author), Kiers, G.H. (author), Verzijl, N. (author), TeKoppele, J.M. (author), Huizinga, T.W.J. (author), de Groot, J. (author), Hanemaaijer, R. (author)
Objective: To analyse matrix metalloproteinases (MMPs) and tissue inhibitor-1 of MMPs (TIMP-1) levels in the systemic circulation and synovial fluid (SF) of patients with RA and to compare these levels with inflammatory and collagen degradation markers. Methods: ProMMP-1, -2, -3, -8, -9, TIMP-1, levels of MMP/ α2-macroglobulin complexes, and...
article 2004
document
TNO Preventie en Gezondheid (author), Tchetverikov, I. (author), Lard, L.R. (author), de Groot, J. (author), Verzijl, N. (author), TeKoppele, J.M. (author), Breedveld, F.C. (author), Huizinga, T.W.J. (author), Hanemaaijer, R. (author)
Objective: To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix metalloproteinase (MMP) activity in α2 macroglobulin (α2M)/MMP complexes and the progression of joint destruction in patients with recent onset rheumatoid arthritis (RA). Methods: 109 patients with RA of recent onset were entered into this longitudinal...
article 2003
document
van Hensbergen, Y. (author), Broxterman, H.J. (author), Hanemaaijer, R. (author), Jorna, A.S. (author), van Lent, N.A. (author), Verheul, H.M.W. (author), Pinedo, H.M. (author), Hoekman, K. (author), Gaubius Instituut TNO (author)
Purpose: On the basis of the finding of marked overexpression in angiogenic microvessels, aminopeptidase N/CD13 has recently been suggested to play a prominent role in tumor angiogenesis. A soluble form of CD13 (sCD13) is present in human plasma, but its role in cancer has not been addressed. We hypothesized that sCD13 would be shed by tumor...
article 2002
document
Sier, C.F.M. (author), Casetta, G. (author), Verheijen, J.H. (author), Tizzani, A. (author), Agape, V. (author), Kos, J. (author), Blasi, F. (author), Hanemaaijer, R. (author), Gaubius Instituut TNO (author)
Matrix metalloproteinases (MMPs) are involved in tumor growth and metastasis, promoting the migration and invasion of cells. In this study, the amount of MMP-2 and MMP-9 activity was measured in urine from superficial bladder carcinoma patients (pTa, pT1) to evaluate their possible diagnostic value. The active and total amount of MMP-2 and MMP-9...
article 2000
document
Hanemaaijer, R. (author), Verheijen, J.H. (author), Maguire, T.M. (author), Visser, H. (author), Toet, K. (author), McDermott, E. (author), O'Higgins, N. (author), Duffy, M.J. (author), Gaubius Instituut TNO (author)
Matrix metalloproteinases (MMP) types 2 and 9 (also known as gelatinase A and B) are thought to be causally involved in cancer invasion and metastasis. In normal as well as in malignant tissue, both these MMPs occur in multiple forms such as inactive precursors, active enzymes and enzyme- inhibitor complexes. Using newly developed quantitative...
article 2000
document
Zhang, B. (author), Ye, S. (author), Herrmann, S.M. (author), Eriksson, P. (author), de Maat, M. (author), Evans, A. (author), Arveiler, D. (author), Luc, G. (author), Cambien, F. (author), Hamsten, A. (author), Watkins, H. (author), Henney, A.M. (author), TNO Preventie en Gezondheid (author)
Background - Gelatinase B, a matrix metalloproteinase that has proteolytic activity against connective tissue proteins, has been suggested to be important in the connective tissue remodeling processes associated with atherogenesis and plaque rupture. This study tested the hypothesis that sequence variation in the promoter region of the...
article 1999
document
Hanemaaijer, R. (author), Visser, H. (author), Konttinen, Y.T. (author), Koolwijk, P. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)
Here we describe a new principle for accessing the activity of the different members of the human matrix-metalloproteinases (MMPs) by a colorimetric assay. Using protein engineering, a modified pro-urokinase was made in which the activation sequence, normally recognized by plasmin (ProArgPheLys ↓ IlelleGlyGly), was replaced by a sequence that is...
article 1998
document
Konttinen, Y.T. (author), Halinen, S. (author), Hanemaaijer, R. (author), Sorsa, T. (author), Hietanen, J. (author), Ceponis, A. (author), Xu, J.W. (author), Manthorpe, R. (author), Whittington, J. (author), Larsson, Å. (author), Salo, T. (author), Kjeldsen, L. (author), Stenman, U.-H. (author), Eisen, A.Z. (author), Gaubius Instituut TNO (author)
Type IV collagenases/gelatinases (matrix metalloproteinases MMP-2 and MMP-9) in labial salivary glands (LSG) and saliva in Sjogren's syndrome (SS) and healthy controls were studied. Zymograms and Western blots disclosed that SS saliva contained 92/82 kD MMP-9/type IV collagenase duplex. Specific activity measurement disclosed 53.1 ± 9.8 U/mg...
article 1998
document
TNO Preventie en Gezondheid Gaubius Instituut TNO (author), Sier, C.F.M. (author), Kubben, F.J.G.M. (author), Ganesh, S. (author), Heerding, M.M. (author), Griffioen, G. (author), Hanemaaijer, R. (author), van Krieken, J.H.J.M. (author), Lamers, C.B.H.W. (author), Verspaget, H.W. (author)
Proteinases are involved in tumour invasion and metastasis. Several matrix metalloproteinases (MMPs) have been shown to be increased in various human carcinomas. We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography. Both MMP levels were...
article 1996
Searched for: subject%3A%22Matrix%255C%2BMetalloproteinase%255C%2B9%22
(1 - 18 of 18)