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- Coopmans, T. (author), Knegjens, R. (author), Dahlberg, A. (author), Maier, D. (author), Nijsten, L. (author), de Oliveira Filho, J. (author), Papendrecht, M. (author), Rabbie, J. (author), Rozp?dek, F. (author), Skrzypczyk, M. (author), Wubben, L. (author), de Jong, W. (author), Podareanu, D. (author), Torres-Knoop, A. (author), Elkouss, D. (author), Wehner, S. (author) article 2021
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van den Hout, A. (author), Fox, J.P. (author)Longitudinal data can be used to estimate the transition intensities between healthy and unhealthy states prior to death. An illness-death model for history of stroke is presented, where time-dependent transition intensities are regressed on a latent variable representing cognitive function. The change of this function over time is described by...article 2015
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Hulskotte, J.H.J. (author), van der Gon, H.A.C.D. (author), Visschedijk, A.J.H. (author), Schaap, M. (author), TNO Bouw en Ondergrond (author)In this article we show that brake wear from road traffic vehicles is an important source of atmospheric (participate) copper concentrations in Europe. Consequently, brake wear also contributes significantly to deposition fluxes of copper to surface waters. We estimated the copper emission due to brake wear to be 2.4 kiloton per year. For...conference paper 2007
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Nueda, M.J. (author), Conesa, A. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Smilde, A.K. (author), Talón, M. (author), Ferrer, A. (author), TNO Kwaliteit van Leven (author)Motivation: Designed microarray experiments are used to investigate the effects that controlled experimental factors have on gene expression and learn about the transcriptional responses associated with external variables. In these datasets, signals of interest coexist with varying sources of unwanted noise in a framework of (co)relation among...article 2007
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Vis, D.J. (author), Westerhuis, J.A. (author), Smilde, A.K. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)Background: Innovative extensions of (M) ANOVA gain common ground for the analysis of designed metabolomics experiments. ASCA is such a multivariate analysis method; it has successfully estimated effects in megavariate metabolomics data from biological experiments. However, rigorous statistical validation of megavariate effects is still...article 2007
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van Loon, M. (author), Vautard, R. (author), Schaap, M. (author), Bergström, R. (author), Bessagnet, B. (author), Brandt, J. (author), Builtjes, P.J.H. (author), Christensen, J.H. (author), Cuvelier, C. (author), Graff, A. (author), Jonson, J.E. (author), Krol, M. (author), Langner, J. (author), Roberts, P. (author), Rouil, L. (author), Stern, R. (author), Tarrasón, L. (author), Thunis, P. (author), Vignati, E. (author), White, L. (author), Wind, P. (author), TNO Bouw en Ondergrond (author)Long-term ozone simulations from seven regional air quality models, the Unified EMEP model, LOTOS-EUROS, CHIMERE, RCG, MATCH, DEHM and TM5, are intercompared and compared to ozone measurements within the framework of the EuroDelta experiment, designed to assess air quality improvement at the European scale in response to emission reduction...article 2007
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Wierenga, P.A. (author), Egmond, M.R. (author), Voragen, A.G.J. (author), de Jongh, H.H.J. (author), TNO Kwaliteit van Leven (author)Unfolding of proteins has often been mentioned as an important factor during the adsorption process at air-water interfaces and in the increase of surface pressure at later stages of the adsorption process. This work focuses on the question whether the folding state of the adsorbed protein depends on the rate of adsorption to the interface,...article 2006
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Bernaards, C.M. (author), Jans, M.P. (author), van den Heuvel, S.G. (author), Hendriksen, I.J. (author), Houtman, I.L. (author), Bongers, P.M. (author), TNO Kwaliteit van Leven (author)Aims: To investigate the longitudinal relation between strenuous leisure time physical activity and psychological complaints (depression and emotional exhaustion) in a Dutch working population in order to find evidence For the preventive role of physical activity in the development of psychological complaints. Methods: All data came from the...article 2006
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Zeegers, M.P. (author), Selen, R.F.M. (author), Kleinjans, J.C.S. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)Objectives: N-nitroso compounds, endogenously formed from nitrate-derived nitrite, are suspected to be important bladder carcinogens. However, the association between nitrate exposure from food or drinking water and bladder cancer has not been substantially investigated in epidemiologic studies. Methods: We evaluated the associations between...article 2006
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van Mispelaar, V.G. (author), Smilde, A.K. (author), de Noord, O.E. (author), Blomberg, J. (author), Schoenmakers, P.J. (author), TNO Kwaliteit van Leven (author)Comprehensive two-dimensional gas chromatography (GC × GC) has proven to be an extremely powerful separation technique for the analysis of complex volatile mixtures. This separation power can be used to discriminate between highly similar samples. In this article we will describe the use of GC × GC for the discrimination of crude oils from...article 2005
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Paulides, M.M. (author), Vossen, S.H.J.A. (author), Zwamborn, A.P.M. (author), van Rhoon, G.C. (author), TNO Defensie en Veiligheid (author)Purpose: To investigate the ability to deposit radiofrequency energy centrally in the neck as a function of antenna positions, number of antennas, and operating frequency. Methods and Materials: Power absorption (PA) distributions in a realistic model of the head-and-neck anatomy are calculated in which the head model is irradiated by an array...article 2005
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- Netzeva, T.I. (author), Worth, A.P. (author), Aldenberg, T. (author), Benigni, R. (author), Cronin, M.T.D. (author), Gramatica, P. (author), Jaworska, J.S. (author), Kahn, S. (author), Klopman, G. (author), Marchant, C.A. (author), Myatt, G. (author), Nikolova-Jeliazkova, N. (author), Patlewicz, G.Y. (author), Perkins, R. (author), Roberts, D.W. (author), Schultz, T.W. (author), Stanton, D.T. (author), van de Sandt, J.J.M. (author), Tong, W. (author), Veith, G. (author), Yang, C. (author), TNO Kwaliteit van Leven (author) article 2005
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Miedema, H.M.E. (author), Vos, H. (author), Instituut voor Ruimtelijke Organisatie TNO (author)Relationships between exposure to noise [metric: day-evening-night levels (DENL)] from stationary sources (shunting yards, a seasonal industry, and other industries) and annoyance are presented. Curves are presented for expected annoyance score, the percentage "highly annoyed" (%HA, cutoff at 72 on a scale from 0 to 100), the percentage "annoyed...article 2004
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Brasser, P. (author), Prins Maurits Laboratorium TNO (author)The heat load, imposed by air-permeable NBC (nuclear, biological, and chemical)-protective suits, can be reduced by improving the air permeability of the suit. However, increased air permeability will reduce the chemical protective performance, since increasing the air permeability of the NBC-protective material will result in higher air...article 2004
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Westerhof, B.E. (author), Gisolf, J. (author), Stok, W.J. (author), Wesseling A, K.H. (author), Karemaker, J.M. (author), TNO Biomedical Instrumentation Technisch Physische Dienst TNO - TH (author)Objective: To test a new method (cross-correlation baroreflex sensitivity, xBRS) for the computation of time-domain baroreflex sensitivity on spontaneous blood pressure and heart interval variability using the EUROBAVAR data set. Methods: We applied xBRS to the 42 records in the EUROBAVAR data set, obtained from 21 patients in the lying and...article 2004
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Miedema, H.M.E. (author), Instituut voor Ruimtelijke Organisatie TNO (author)Relationships between exposure to noise [metric: day-night level (DNL) or day-evening-night level (DENL)] from a single source (aircraft, road traffic, or railways) and annoyance based on a large international dataset have been published earlier. Also for stationary sources relationships have been assessed. Here the annoyance equivalents model...article 2004
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Durrieu, P. (author), Hofmans, G. (author), Ajello, G. (author), Boot, R. (author), Aurégan, Y. (author), Hirschberg, A. (author), Peters, M.C.A.M. (author), Technisch Physische Dienst TNO - TH (author)The low frequency response of orifices (slit, circular diaphragm, and perforated plate) in the presence of mean flow is well predicted by a quasisteady theory. A refinement is brought to the theory by considering a Mach number dependent vena contracta coefficient. The measurements of the vena contracta coefficient of a slit agree well with the...article 2001
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Freidig, A. (author), Hofhuis, M. (author), van Holstijn, I. (author), Hermens, J. (author), TNO Voeding (author)Glutathione (GSH) depletion is often reported as an early cytotoxic effect, caused by many reactive organic chemicals. In the present study, GSH depletion in primary rat hepatocytes was used as an in vitro effect-equivalent to measure the toxic potency of α,β-unsaturated esters (acrylates and methacrylates). 2. When these compounds were...article 2001
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Prins Maurits Laboratorium TNO (author), Linders, M.J.G. (author), van den Broeke, L.J.P. (author), Kapteijn, F. (author), Moulijn, J.A. (author), van Bokhoven, J.J.G.M. (author)Adsorption isotherms of hexafluoropropylene (HFP), methanol and ethanol were measured under dry and humid conditions using Norit R1 carbon. The presence of water lowered the HFP capacity over the whole pressure range as compared to the single component isotherm, while increasing the methanol and ethanol capacity. The Dubinin-Radushkevich...article 2001
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Oomen, A.G. (author), Sips, A.J.A.M. (author), Groten, J.P. (author), Sijm, D.T.H.M. (author), Tolls, J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Children can take up contaminated soil via hand-to-mouth behavior. The contaminants can be mobilized from the soil by digestive juices and thus become available for intestinal absorption (i.e. become bioaccessible). In the present study components of an in vitro digestion model were varied to study their effect on the mobilization of several...article 2000
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