Mass-Balance Method for Provision of Net Zero Emission Transport Services

There is a strong need to reduce emissions from transport and logistics. Electrificationand use of greener energy carriers and fuels provide a ready way to reduce emissions, but thesetechnologies are generally more expensive than the conventional ones they are replacing. Fortunately,some shippers are willing to pay the extra cost to ship their...

Health Risk Assessment of Ortho-Toluidine Utilising Human Biomonitoring Data of Workers and the General Population

The aim of this work was to demonstrate how human biomonitoring (HBM) data can be used to assess cancer risks for workers and the general population. Ortho-toluidine, OT (CAS 95-53-4) is an aniline derivative which is an animal and human carcinogen and may cause methemoglobinemia. OT is used as a curing agent in epoxy resins and as intermediate...

Theoretical Background of Occupational Exposure Models: report of an Expert Workshop of the ISES Europe Working Group “Exposure Models”

On 20 October 2020, the Working Group “Exposure Models” of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe) organised an online workshop to discuss the theoretical background of models for the assessment of occupational exposure to chemicals. In this report, participants of the workshop with an active...

Real-time intelligent production monitoring of a North Sea asset

The increasing complexity of natural gas extraction because of reducing reserves, complex behavior and more intricate contractual rules (due to liberalization of the West European energy markets) creates a need for more effective production efficiency. In order to deal with these challenges Wintershall is realizing a real-time monitoring system...

Forward and inverse modeling of near-well flow using discrete edge-based vector potentials

Homogeneous effective permeabilities in the near-well region are generally obtained using analytical solutions for transient flow. In contrast, this paper focuses on heterogeneous permeability obtained from steady flow solutions, although extensions to unsteady flow are introduced too. Exterior calculus and its discretized form have been used as...

Transdermal administration of radiolabelled [14C]rotigotine by a patch formulation: A mass balance trial

Background and objective: The dopamine agonist rotigotine has been formulated in a silicone-based transdermal system for once-daily administration. The objective of the present study was to characterise the mass balance of rotigotine in humans after administration of a single transdermal patch containing radiolabelled [14C]rotigotine and to...

Percutaneous absorption of mexoryl SX® in human volunteers: Comparison with in vitro data

The potential human health risk of UV filters depends on their toxicity and the human systemic exposure which is a function of the extent of percutaneous absorption of the topically applied substance into the human organism. Using a 'mass balance' approach, a study was designed to investigate the systemically absorbed dose of [14C]-Mexoryl SX®...

Balance of trichloroacetic acid in the soil top layer

Since the ban on the use of trichloroacetic acid (TCAA) as a herbicide in several countries, TCAA is still found ubiquitously in the environment. The presence of TCAA nowadays is suggested to originate mainly from the atmospheric degradation of tetrachloroethene. Our mass balance calculations indicate that this may be true for the presence of...

Microbial transglutaminase production by Streptoverticillium mobaraense: Analysis of amino acid metabolism using mass balances

Metabolic flows, especially those of amino acids, were determined and analyzed at different stages of a batch fermentation for microbial transglutaminase production by Streptoverticillium mobaraense. The method is mainly based on mass balances and measurements of amino acids and other metabolites. The measurements included the consumption rate...