Searched for: subject:"Male"
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document
Feron, V.J. (author), Kruysse, A. (author), Dreef Van Der Meulen, H.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The sub-acute inhalation toxicity of furfural was studied in Syrian golden hamsters. Four groups of ten males and ten females each were repeatedly exposed to furfural vapour at concentrations of 0, 20, 115 and 552 ppm (0, 77,448 and 2165 mg/m3 air) respectively for 6 hours/day, 5 days/week during a period of 13 weeks. At the highest exposure...
article 1979
document
Feron, V.J. (author), Kruysse, A. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Wistar rats were exposed to atmospheres containing 0 (control) or 5000 ppm vinyl chloride monomer (VCM), 7 h/day, 5 days/week, for a period of 52 weeks. After 4, 13, 26 and 52 weeks each time 10 rats/sex/group were killed and subjected to extensive examinations. The present paper deals with growth, mortality, haematology, clinical chemistry and...
article 1979
document
Benschop, H.P. (author), van den Berg, G.R. (author), van Hooidonk, C. (author), de Jong, L.P.A. (author), Kientz, C.E. (author), Berends, F. (author), Kepner, L.A. (author), Meeter, E. (author), Visser, R.P.L.S. (author), Medisch Biologisch Laboratorium TNO (author)
Three new nonquaternary oximes have been evaluated with respect to their antidotal activities against organophosphate poisoning. The oximes 1,2,3-thiadiazole-5-carboxaldoxime (1, pKa = 7.6), 2-methyl-1,3,4-thiadiazole-5-carboxaldoxime (2, pKa = 8.4), and 3-methyl-1,2,4-thiadiazole-5-carboxaldoxime (3, pKa = 7.0) were prepared in yields of 56, 24...
article 1979
document
Gaillard, A.W.K. (author), Perdok, J. (author), Instituut voor Zintuigfysiologie TNO (author)
Slow EEG potentials (Fz, Cz, Pz) and heart rate were recorded during the foreperiod of a reaction task, which involved different levels of discrimination difficulty. A simple reaction task was compared with a selective reaction task where either an easy or a difficult discrimination was required. In general, the terminal amplitude of the CNV was...
article 1979
document
Vos, O. (author), Wilschut, I.J.C. (author), Medisch Biologisch Laboratorium TNO (author)
Mobilization of CFUs from haemopoietic tissues into circulation was studied after injection of different bacterial lipopolysaccharides (LPS), zymosan, phytohaemagglutinin (PHA), concanavalin A (Con A), trypsin and di-isopropyl-fluorophosphate-inhibited trypsin. All bacterial LPS used gave an increase of CFUs in the peripheral blood at 1 h after...
article 1979
document
Feron, V.J. (author), Kruysse, A. (author), Immel, H.R. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, salivation, nasal discharge,...
article 1979
document
Tanger, H.J. (author), Vanwersch, R.A.P. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
A method is described whereby open field behaviour of rats can be automatically registered using a TV camera, a video converter, an X-Y recorder and a papertape puncher. Use is made of the scanning properties of the TV camera to obtain the X and Y coordinates of the rat's position and to print this position on an X-Y recorder to obtain the...
article 1978
document
Widmer, M.B. (author), Balner, H. (author), Primatencentrum TNO (author)
Ten antisera containing antibodies directed against specificities controlled by the Ia1 locus of rhesus monkeys were tested for their ability to inhibit the MLC reaction. In cultures with responding cells from the serum producer, all sera with anti-Ia1, activity depressed the stimulatory capacity of cells carrying the Ia1 antigen in question. In...
article 1978
document
von Lossonczy, T.O. (author), Ruiter, A. (author), Bronsgeest-Schoute, H.C. (author), van Gent, C.M. (author), Hermus, R.J.J. (author)
A cross-over study was done with 19 male and 23 female volunteers living in a monastery and a convent, respectively. The effect of a fat fish (mackerel) diet on the blood serum lipid composition was studied. As the normal diet of these volunteers was of the lacto-ovo-vegetarian type, a control diet in which the fish was replaced by full-fat...
article 1978
document
Vos, O. (author), Medisch Biologisch Laboratorium TNO (author)
Chemicals/CAS: Lipopolysaccharides
article 1978
document
Wolthuis, O.L. (author), Kepner, L.A. (author), Medisch Biologisch Laboratorium TNO (author)
The bisquarternary mono-oxime HI-6, and to a lesser extent HS-6, caused functional recovery of neuromuscular transmission in vivo and in vitro when given 60 min after soman, i.e. when the soman-cholinesterase (AChE) complex is said to be fully 'aged'. Atropinised rats, with the tracheas intubated, received 4 x LD50 soman i.v. and were kept alive...
article 1978
document
Kepner, L.A. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The bisquaternary mono-oximes HS-6 and HI-6 may both be considered as potential therapeutic agents for soman intoxication. It has been found that HI-6 was superior to an equal dose of HS-6 in the treatment of soman intoxication in mice and rats. Not only did HI-6 protect against higher levels of soman, but also fewer 'delayed deaths' were seen...
article 1978
document
Gaubius instituut TNO (author), van Ruijven-Vermeer, I.A.M. (author), Nieuwenhuizen, W. (author)
Rat fibrinogen was purified from rat plasma by using lysine-Sepharose chromatography, repeated precipitation with 25%-satd. (HN4)2SO4 and gel chromatography on Sepharose 6B. To minimize proteolytic activity, rats were injected intravenously with Trasylol before bleeding and the collected blood was treated with Trasylol and di-isopropyl...
article 1978
document
Jonkman, E.J. (author), Mosmans, P.C.M. (author)
other 1977
document
Kruysse, A. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)
The inhalation toxicity of peroxyacetyl nitrate (PAN) was examined in acute (single exposure), subacute (4-wk repeated exposure) and subchronic (13-wk repeated exposure) studies in rats. The 4-hr LC50 was found to be 95 ppm. In the 4-wk study rats were exposed to 0, 0.9, 4.1 or 11.8 ppm PAN vapor for 6 hr/day, 5 days/wk. Exposure to 11.8 ppm...
article 1977
document
van Velsen, F.L. (author), Nickolson, V.J. (author), Medisch Biologisch Laboratorium TNO Medisch Fysisch Instituut TNO (author)
The effects of the myotonic agent, 9-anthroic acid (ANCA), and the acetylcholinesterase (AChE) inhibitor, soman, on the isolated phrenic nerve-diaphragm preparation of the rat were studied. ANCA induced after-contractions which followed the twitches evoked by either direct or indirect stimulation. In the intermittently stimulated muscle the...
article 1977
document
Wolthuis, O.L. (author), Clason-van der Wiel, H.J. (author), Visser, R.P.L.S. (author), Medisch Biologisch Laboratorium TNO Chemisch Laboratorium TNO (author)
Atropinised anaesthetised rats were injected i.v. with 4, 6 or 8 x LD50 of the organophosphorous anticholinesterase soman. Subsequent treatment with one dose of HS 6 (100 mg/kg, i.v.) delayed respiratory failure by 1 h or more; a further postponement was obtained when an additional HS 6 infusion was given. At the same infusion rate, HS 6 blood...
article 1976
document
Nickolson, V.J. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The effects of Piracetam, Naftidrofuryl and methamphetamine on several parameters of cerebral energy metabolism have been studied. At variance with some reports in the literature neither Piracetam nor Naftidrofuryl affected the cerebral contents of adenine nucleotides and, accordingly, both substances were without effect on the adenylate energy...
article 1976
document
de Groot, A.P. (author), Slump, P. (author), Feron, V.J. (author), van Beek, L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To find out whether alkali treated proteins possess nephrotoxic properties, feeding studies were conducted with drastically treated soybean protein and casein, and also with lysinoalanine (LAL), the amino acid known to be formed in proteins subjected to high pH at an elevated temperature. The feeding of synthesized LAL to rats at dietary levels...
article 1976
document
Nickolson, V.J. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The effect of Piracetam on rat cerebral protein metabolism in vivo and in vitro was studied. It was found that the drug stimulates the uptake of labelled leucine by cerebral cortex slices, has no effect on the incorporation of leucine into cerebral protein, neither in slices nor in vivo, but inhibits the breakdown of newly formed protein in...
article 1976
Searched for: subject:"Male"
(1,881 - 1,900 of 1,911)

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