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van Groen, B.D. (author), Krekels, E.H.J. (author), Mooij, M.G. (author), van Duijn, E. (author), Vaes, W.H.J. (author), Windhorst, A.D. (author), van Rosmalen, J. (author), Hartman, S.J.F. (author), Hendrikse, N.H. (author), Koch, B.C.P. (author), Allegaert, K. (author), Tibboel, D. (author), Knibbe, C.A.J. (author), de Wildt, S.N. (author)
Midazolam is metabolized by the developmentally regulated intestinal and hepatic drug-metabolizing enzyme cytochrome P450 (CYP) 3A4/5. It is frequently administered orally to children, yet knowledge is lacking on the oral bioavailability in term neonates up until 1 year of age. Furthermore, the dispositions of the major metabolites 1-OH...
article 2021
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Coenen, P. (author), Robroek, S.J.W. (author), van der Beek, A.J. (author), Boot, C.R.L. (author), van Lenthe, F.J. (author), Burdorf, A. (author), Oude Hengel, K.M. (author)
Background: This individual patient data (IPD) meta-analysis aimed to investigate socioeconomic inequalities in effectiveness on healthy behavior of, and compliance to, workplace health promotion programs. Methods: Dutch (randomized) controlled trials were identified and original IPD were retrieved and harmonized. A two-stage meta-analysis was...
article 2020
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van den Dries, M.A. (author), Lamballais, S. (author), El Marroun, H. (author), Pronk, A. (author), Spaan, S. (author), Ferguson, K.K. (author), Longnecker, M.P. (author), Tiemeier, H. (author), Guxens, M. (author)
Background: Prenatal exposure to organophosphate (OP) pesticides associate with impaired neurodevelopment in humans and animal models. However, much uncertainty exists about the brain structural alterations underlying these associations. The objective of this study was to determine whether maternal OP pesticide metabolite concentrations in urine...
article 2020
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Liu, Y. (author), Toet, A. (author), Krone, T. (author), van Stokkum, R. (author), Eijsman, S. (author), van Erp, J.B.F. (author)
The affective appraisal of odors is known to depend on their intensity (I), familiarity (F), detection threshold (T), and on the baseline affective state of the observer. However, the exact nature of these relations is still largely unknown. We therefore performed an observer experiment in which participants (N = 52) smelled 40 different odors ...
article 2020
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Pasma, W. (author), Wesselink, E.M. (author), van Buuren, S. (author), de Graaff, J.C. (author), van Klei, W.A. (author)
Physiologic data from anesthesia monitors are automatically captured. Yet erroneous data are stored in the process as well. While this is not interfering with clinical care, research can be affected. Researchers should find ways to remove artifacts. The aim of the present study was to compare different artifact annotation strategies, and to...
article 2020
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Koopman, A.S. (author), Naf, M. (author), Baltrusch, S.J. (author), Kingma, I. (author), Rodriguez-Guerrero, C. (author), Babic, J. (author), de Looze, M.P. (author), van Dieën, J.H. (author)
The number one cause of disability in the world is low-back pain, with mechanical loading as one of the major risk factors. To reduce mechanical loading, exoskeletons have been introduced in the workplace. Substantial reductions in back muscle activity were found when using the exoskeleton during static bending and manual materials handling....
article 2020
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Oosterman, J.E. (author), Koekkoek, L.L. (author), Foppen, E. (author), Unmehopa, U.A. (author), Eggels, L. (author), Verheij, J. (author), Fliers, E. (author), la Fleur, S.E. (author), Kalsbeek, A. (author)
Objective. Eating out of phase with the endogenous biological clock alters clock and metabolic gene expression in rodents and can induce obesity and type 2 diabetes mellitus. Diet composition can also affect clock gene expression. Here, we assessed the combined effect of diet composition and feeding time on (1) body composition, (2) energy...
article 2020
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Hoevenaars, F.P.M. (author), Berendsen, C.M.M. (author), Pasman, W.J. (author), van den Broek, T.J. (author), Barrat, E. (author), de Hoogh, I.M. (author), Wopereis, S. (author)
In public health initiatives, generic nutrition advice (GNA) from national guidelines has a limited effect on food-intake improvement. Personalized nutrition advice (PNA) may enable dietary behavior change. A monocentric, randomized, parallel, controlled clinical trial was performed in males (n = 55) and females (n = 100) aged 25 to 70 years....
article 2020
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Hendriks, H. (author), van de Rest, O. (author), Snippe, A. (author), Kieboom, J. (author), Hogenelst, K. (author)
Long-term alcohol abuse is associated with poorer cognitive performance. However, the associations between light and moderate drinking and cognitive performance are less clear. We assessed this association via cross-sectional and longitudinal analyses in a sample of 702 Dutch students. At baseline, alcohol consumption was assessed using...
article 2020
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Stroek, K. (author), Heijboer, A.C. (author), Bouva, M.J. (author), van der Ploeg, C.P.B. (author), Heijnen, M.L.A. (author), Weijman, G. (author), Bosch, A.M. (author), de Jonge, R. (author), Schielen, P.C.J.I. (author), van Trotsenburg, A.S.P. (author), Boelen, A. (author)
Objective: Congenital hypothyroidism (CH) is defined as thyroid hormone deficiency at birth due to disorders of the thyroid gland (thyroidal CH, CH-T), or the hypothalamus or pituitary (central CH, CH-C). The Dutch Newborn Screening (NBS) strategy is primarily based on determination of thyroxine (T4) concentrations in dried blood spots followed,...
article 2020
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Verlinden, D.A. (author), Schuller, A.A. (author), Verrips, G.H.W. (author), Reijneveld, S.A. (author)
Young children rely on their parents with respect to oral health routines. However, parental knowledge on this topic is often insufficient. Well-child care may be an excellent route to reach parents because almost all of them attend. To evaluate the effectiveness of an 8.5 min web-based film about oral health, provided by well-child care, a non...
article 2020
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Perini, F. (author), Powell, T. (author), Watt, S.J. (author), Downing, P.E. (author)
The brain must interpret sensory input from diverse receptor systems to estimate object properties. Much has been learned about the brain mechanisms behind these processes in vision, but our understanding of haptic perception remains less clear. Here we examined haptic judgments of object size, which require integrating multiple cutaneous and...
article 2020
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Schoen, E.D. (author), Wopereis, S. (author)
BACKGROUND: Parallel intervention studies involving volunteers usually require a procedure to allocate the subjects to study-arms. Statistical models to evaluate the different outcomes of the study-arms will include study-arm as a factor along with any covariate that might affect the results. To ensure that the effects of the covariates are...
article 2020
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Coenen, P. (author), Hulsegge, G. (author), Daams, J.G. (author), van Geenen, R.G. (author), Kerkhoffs, G.M. (author), van Tulder, M.W. (author), Huirne, J.A. (author), Anema, J.R. (author), Kuijser, P.P. (author)
Objectives Orthopaedic surgery is primarily aimed at improving function and pain reduction. Additional integrated care may enhance patient’s participation in sports and work, possibly improving performance of physical activities and quality of life (QoL). We aimed to assess the effectiveness of integrated care among orthopaedic surgery patients....
article 2020
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Krone, T. (author), Boessen, R. (author), Bijlsma, S. (author), van Stokkum, R. (author), Clabbers, N.D.S. (author), Pasman, W.J. (author)
Background. N-of-1 designs gain popularity in nutritional research because of the improving technological possibilities, practical applicability and promise of increased accuracy and sensitivity, especially in the field of personalized nutrition. This move asks for a search of applicable statistical methods. Objective. To demonstrate the...
article 2020
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van den Dries, M.A. (author), Guxens, M. (author), Spaan, S. (author), Ferguson, K.K. (author), Philips, E. (author), Santos, S. (author), Jaddoe, V.W.V. (author), Ghassabian, A. (author), Trasande, L. (author), Tiemeier, H. (author), Pronk, A. (author)
BACKGROUND: Prenatal exposures to phthalates and bisphenols are associated with impaired brain development in animals. However, epidemiological studies investigating the association between prenatal phthalate or bisphenol exposure and cognition have produced mixed findings and mostly had modest sample sizes and measured the exposure during the...
article 2020
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Pannebakker, N.M. (author), Fleuren, M.A.H. (author), Vlasblom, E. (author), Numans, M.E. (author), Reijneveld, S.A. (author), Kocken, P.L. (author)
Background: The aim of this study is to understand the determinants of adherence to wrap-around care (WAC) by professional care providers working in child and family services. WAC is a care coordination method targeting families with complex needs. The core components of WAC involve activating family members and the social network, integrating...
article 2019
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Bouwhuis, S. (author), Geuskens, G.A. (author), Boot, C.R.L. (author), van der Beek, A.J. (author), Bongers, P.M. (author)
Introduction Precarious employment is associated with poor health. Among employees in precarious employment, those with multiple jobs may face additional health risks, e.g. due to combining work schedules and job roles. Our research question is: do differences in health exist between multiple and single job holders in precarious employment?...
article 2019
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Braeckman, L. (author), Venema, A. (author), Zoelen, S.A.V. (author), Hermans, L. (author), de Ridder, M. (author), Ergör, A. (author), Combining, O. (author), Diaeresis, A. (author), van der Laan, G. (author), van Dijk, F. (author)
OBJECTIVES: To increase knowledge and skills regarding occupational health surveillance and research in professionals. METHODS: Following the ADDIE model (Analysis, Design, Development, Implementation and Evaluation), several training modules have been designed and implemented in the course of 2016. Evaluation forms were distributed to 42...
article 2019
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Huijs, J.J.J.M. (author), Houtman, I.L.D. (author), Taris, T.W. (author), Blonk, R.W.B. (author)
Background The present study aimed to investigate the effects of a stepwise, bottom-up participatory program with a tailor-made intervention process addressing the level of mental retirement in a sample of Dutch employees. Mental retirement refers to feelings of being disconnected from your work and your organization. Prevention of mental...
article 2019
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