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Koeman, T. (author), Slottje, P. (author), Kromhout, H. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Vermeulen, R. (author)Objectives Although a study among utility workers found an increased risk for acute myocardial infarction and arrhythmia-related deaths associated with occupational extremely low-frequency magnetic fields (ELF-MF) exposure, later studies largely failed to replicate these findings. This study investigated the association between occupational ELF...article 2013
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Ramautar, R. (author), Berger, R. (author), van der Greef, J. (author), Hankemeier, T. (author)Metabolomics provides a direct functional read-out of the physiological status of an organism and is in principle ideally suited to describe someone's health status. Whereas only a limited number of small metabolites are used in the clinics, in inborn errors of metabolism an extensive repertoire of metabolites are used as biomarkers. We discuss...article 2013
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Alić, L. (author), van Vliet, M. (author), Wielopolski, P.A. (author), ten Hagen, T.L.M. (author), van Dijke, C.F. (author), Niessen, W.J. (author), Veenland, J.F. (author)Experimental evidence supports an association between heterogeneity in tumor perfusion and response to chemotherapy/radiotherapy, disease progression and malignancy. Therefore, changes in tumor perfusion may be used to assess early effects of tumor treatment. However, evaluating changes in tumor perfusion during treatment is complicated by...article 2013
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Bekers, D.J. (author), Lepelaars, E.S.A.M. (author)Steel ships with a magnetic signature requirement are equipped with a degaussing system to reduce their perceptibility for magnetic influence mines. To be able to reduce the magnetic signature accurately, a proper distribution of coils over the ship is essential. Finding the best distribution of coils is a complex optimisation problem, involving...conference paper 2013
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van Dijk, N.J.M. (author), van de Wouw, N. (author), Doppenberg, E.J.J. (author), Oosterling, H.A.J. (author), Nijmeijer, H. (author)Chatter is an instability phenomenon in machining processes which limits productivity and results in inferior workpiece quality, noise and rapid tool wear. The increasing demand for productivity in the manufacturing community motivates the development of an active control strategy to shape the chatter stability boundary of manufacturing...article 2012
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Nachabé, R. (author), van der Hoorn, J.W.A. (author), van de Molengraaf, R. (author), Lamerichs, R. (author), Pikkemaat, J. (author), Sio, C.F. (author), Hendriks, B.H.W. (author), Sterenborg, H.J.C.M. (author)Objectives: To validate near-infrared (NIR)-based optical spectroscopy measurements of hepatic fat content using a minimally invasive needle-like probe with integrated optical fibers, enabling real-time feedback during percutaneous interventions. The results were compared with magnetic resonance spectroscopy (MRS) as validation and with...article 2012
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van den Dool, T.C. (author), Kruizinga, B. (author), Braam, B.C. (author), Hamelinck, R.F.M.M. (author), Loix, N. (author), van Loon, D. (author), Dams, J. (author)TNO, together with its partners, have designed a cryogenic scanning mechanism for use in the SAFARI Fourier Transform Spectrometer (FTS) on board of the SPICA mission. SPICA is one of the M-class missions competing to be launched in ESA's Cosmic Vision Programme in 2022. JAXA leads the development of the SPICA satellite and SRON is the prime...conference paper 2012
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Zwamborn, A.P.M. (author)Voor het leven op aarde speelt het aardmagnetisch veld een cruciale rol om ons tegen deze stroom geladen deeltjes te beschermen. In extreme situaties merken we de effecten van ruimteweer zelfs op aarde. Inzicht in het ruimteweer is daarom belangrijk om tijdig te kunnen beoordelen of zonneactiviteit invloed kan uitoefenen op de aarde en de...article 2012
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Naus, H.W.L. (author)The Jiles-Atherton effective field theory of ferromagnetic hysteresis is consistently extended to describe the magnetomechanical effect. Whereas Jiles has proposed two such models, one for constant stress and a different one for varying stress, our formalism includes both situations. It is also possible to simultaneously vary applied field and...article 2011
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van Meel, P.A. (author), Erich, S.J.F. (author), Huinink, H.P. (author), Kopinga, K. (author), DE Jong, J. (author), Adan, O.C.G. (author)Moisture accumulation inside wood causes favorable conditions for decay. Application of a coating alters the moisture sorption of wood and prevents accumulation of moisture. This paper presents the results of a nuclear magnetic resonance (NMR) study on the influence of a coating on the moisture absorption of wood. NMR allows to determine both...article 2011
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van Ginneken, V.J.T. (author), Verheij, E. (author), Hekman, M. (author), van der Greef, J. (author), Feskens, E.J.M. (author), Poelmann, R.E. (author)We investigated with LC-MS techniques, measuring approximately 109 lipid compounds, in mouse brain and liver tissue after 48 hours of starvation and a High-Fat Diet if brain and liver lipid composition changed. We measured Cholesterolesters (ChE), Lysophosphatidyl-cholines (LPC), Phosphatidylcholine (PC), Sphingomyelin (SPM) and Triacylglycerols...bookPart 2011
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de Baar, M.R. (author), Bongers, W.A. (author), van Berkel, M. (author), Doelman, N.J. (author), Hennen, B.A. (author), Nuij, P. (author), Oosterbeek, J.W. (author), Steinbuch, M. (author), Westerhof, E. (author), Witvoet, G. (author)Resistive magneto-hydrodynamic instabilities are expected to limit the performance of nuclear fusion reactors. Prime examples are the sawtooth instability and the neoclassical tearing modes. The sawtooth instability will affect the refueling of the plasma core and the fast particle concentration. In reactor relevant conditions, the sawtooth can...conference paper 2011
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Brouwers, J. (author), Anneveld, B. (author), Goudappel, G.J. (author), Duchateau, G. (author), Annaert, P. (author), Augustijns, P. (author), Zeijdner, E. (author)In the present study, we demonstrated the value of two advanced tools, the TNO gastric and small Intestinal Model (TIM-1) and magnetic resonance imaging (MRI), for the in vitro evaluation of food-dependent disintegration of immediate release fosamprenavir tablets. Upon introduction of a tablet with the nutritional drink Scandishake Mix® in the...article 2011
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Alić, L. (author), Haeck, J.C. (author), Bol, K. (author), Klein, S. (author), van Tiel, S.T. (author), Wielopolski, P.A. (author), Bijster, M. (author), Bernsen, M. (author), de Jong, M. (author), Niessen, W.J. (author), Veenland, J.F. (author)Background:Magnetic resonance imaging (MRI), together with histology, is widely used to diagnose and to monitor treatment in oncology. Spatial correspondence between these modalities provides information about the ability of MRI to characterize cancerous tissue. However, registration is complicated by deformations during pathological processing,...article 2011
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Bol, K. (author), Haeck, J.C. (author), Alić, L. (author), Bernsen, M. (author), de Jong, M. (author), Niessen, W.J. (author), Veenland, J.F. (author)Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is becoming an indispensable tool to non-invasively study tumor characteristics. However, many different DCE-analysis methods are currently being used. To compare and validate different methods, histology is the gold standard. For this purpose, exact co-localization between histology...conference paper 2011
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Cremer, H. (author), Bunnik, F.P.M. (author), Donders, T.H. (author), Hoek, W.Z. (author), Koolen-Eekhout, M. (author), Koolmees, H.H. (author), Lavooi, E. (author), TNO Bouw en Ondergrond (author)A 400-year sediment record from an 18 m deep scour hole lake (Haarsteegse Wiel) near the Meuse River in the Netherlands was investigated for past changes in water quality, flooding frequency and landscape change using geophysical, geochemical and micropaleontological information. The results are highly significant for determining long-term...article 2010
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van Wanum, M. (author), Monni, S. (author), van Vliet, F.E. (author)The protection of phased array T/R modules from high input power levels is an important aspect in reducing vulnerability of radars and communication systems RF electronics in modern military platforms. Different categories of threats can damage the sensitive electronics in the phased-array radar, like hostile high power electro-magnetic (HPEM)...conference paper 2010
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Sawdy, A. (author), Lubelli, B. (author), Voronina, V. (author), Pel, L. (author), TNO Bouw en Ondergrond (author)Poultices are often used to extract salts from salt-deteriorated objects, but the results achieved can be highly variable. Currently, poulticing materials and methodologies are selected empirically, but many variables affect the treatment outcome, so achieving the 'best fit' between available materials, application methods and substrate...article 2010
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Naber, R.C.G. (author), Asadi, K. (author), Blom, P.W.M. (author), de Leeuw, D.M. (author), de Boer, B. (author), TNO Industrie en Techniek (author)A memory functionality is a prerequisite for many applications of electronic devices. Organic nonvolatile memory devices based on ferroelectricity are a promising approach toward the development of a low-cost memory technology. In this Review Article we discuss the latest developments in this area with a focus on three of the most important...article 2010
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Petković, J. (author), Huinink, H.P. (author), Pel, L. (author), Kopinga, K. (author), van Hees, R.P.J. (author), TNO Bouw en Ondergrond (author)We have investigated whether a plaster which has two plaster layers with different pore sizes can act as a salt accumulating plaster system, in which salt crystallizes in the base layer of the plaster and not in the substrate or at the external surface. We used two substrates; fired-clay brick and Bentheim sandstone. On the substrate we applied...article 2010