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van der Greef, J. (author), van Wietmarschen, H. (author), van Ommen, B. (author), Verheij, E.R. (author)
Metabolites have played an essential role in our understanding of life, health, and disease for thousands of years. This domain became much more important after the concept of metabolism was discovered. In the 1950s, mass spectrometry was coupled to chromatography and made the technique more application-oriented and allowed the development of...
article 2013
Braaksma, M. (author), Bijlsma, S. (author), Coulier, L. (author), Punt, P.J. (author), van der Werf, M.J. (author)
For the optimization of microbial production processes, the choice of the quantitative phenotype to be optimized is crucial. For instance, for the optimization of product formation, either product concentration or productivity can be pursued, potentially resulting in different targets for strain improvement. The choice of a quantitative...
article 2011