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Wopereis, S. (author), Radonjic, M. (author), Rubingh, C. (author), van Erk, M. (author), Smilde, A. (author), van Duyvenvoorde, W. (author), Cnubben, N. (author), Kooistra, T. (author), van Ommen, B. (author), Kleemann, R. (author)
The prevalence of diabetes mellitus Type 2 could be significantly reduced by early identification of subjects at risk, allowing for better prevention and earlier treatment. Glucose intolerance (GI) is a hallmark of the prediabetic stage. This study aims at identifying 1) prognostic biomarkers predicting the risk of developing GI later in life...
article 2012
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Vos, P.A.J.M. (author), Degroot, J. (author), Barten-Van Rijbroek, A.D. (author), Zuurmond, A.-M. (author), Bijlsma, J.W.J. (author), Mastbergen, S.C. (author), Lafeber, F.P.J.G. (author)
Osteoarthritis is a highly prevalent disease, age being the main risk factor. The age-related accumulation of advanced-glycation-endproducts (AGEs) adversely affects the mechanical and biochemical properties of cartilage. The hypothesis that accumulation of cartilage AGEs in combination with surgically induced damage predisposes to the...
article 2012
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Pellis, L. (author), van Erk, M.J. (author), van Ommen, B. (author), Bakker, G.C.M. (author), Hendriks, H.F.J. (author), Cnubben, N.H.P. (author), Kleemann, R. (author), van Someren, E.P. (author), Bobeldijk, I. (author), Rubingh, C.M. (author), Wopereis, S. (author)
We introduce the metabolomics and proteomics based Postprandial Challenge Test (PCT) to quantify the postprandial response of multiple metabolic processes in humans in a standardized manner. The PCT comprised consumption of a standardized 500 ml dairy shake containing respectively 59, 30 and 12 energy percent lipids, carbohydrates and protein....
article 2012
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Joosten, M.M., (author), van, Erk, M.J. (author), Pellis, L, (author), Witkamp, R.F., (author), Hendriks, H.F. (author)
article 2012
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Bastiaansen-Jenniskens, Y.M. (author), Clockaerts, S. (author), Feijt, C. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Bridts, C. (author), de Clerck, L. (author), de Groot, J. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author)
Objective: Adipose tissue is known to release inflammatory cytokines and growth factors. In this exploratory study, the authors examined whether the infrapatellar fat pad (IPFP) closely located to cartilage in the knee joint can affect cartilage metabolism. In addition, the authors analysed whether the macrophage types present in IPFP could...
article 2012
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Kleemann, R. (author), Bureeva, S. (author), Perlina, A. (author), Kaput, J. (author), Verschuren, L. (author), Wielinga, P.Y. (author), Hurt-Camejo, E. (author), Nikolsky, Y. (author), van Ommen, B. (author), Kooistra, T. (author)
Successful drug development has been hampered by a limited understanding of how to translate laboratory-based biological discoveries into safe and effective medicines. We have developed a generic method for predicting the effects of drugs on biological processes. Information derived from the chemical structure and experimental omics data from...
article 2011
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