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Kim, Y.H. (author), Warren, S.H. (author), Kooter, I. (author), Williams, W.C. (author), George, I.J. (author), Vance, S.A. (author), Hays, M.D. (author), Higuchi, M.A. (author), Gavett, S.H. (author), DeMarini, D.M. (author), Jaspers, I. (author), Gilmour, M.I. (author)Abstract Background: Open burning of anthropogenic sources can release hazardous emissions and has been associated with increased prevalence of cardiopulmonary health outcomes. Exposure to smoke emitted from burn pits in mili tary bases has been linked with respiratory illness among military and civilian personnel returning from war zones....article 2021
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van Helden, H.P.M. (author), Kuijpers, W.C. (author), Diemel, R.V. (author)The purpose of the present study was to investigate: (1) the acute effects of sulfur mustard on airway, lung, and surface tension of bronchoalveolar lavage fluid (BALfluid) in guinea pigs following intratracheal (i.t.) exposure to 1LD50 of an aerosolized solution of sulfur mustard in saline, and (2) the therapeutic efficacy of i.t....article 2004
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Feron, V.J. (author), Kittel, B. (author), Kuper, C.F. (author), Ernst, H. (author), Rittinghausen, S. (author), Muhle, H. (author), Koch, W. (author), Gamer, A. (author), Mallett, A.K. (author), Hoffmann, H.D. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Two independent bioassays are available which have examined the potential carcinogenicity of monomeric and polymeric methylene diphenyl diisocyanate (MDI) following long-term inhalation exposure in rats. These studies are not directly comparable, however, due to differences in design and conduct of the in-life phase, and differences in...article 2001
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Schultze, A.E. (author), Emeis, J.J. (author), Roth, R.A. (author), Gaubius Instituut TNO (author)The monocrotaline pyrrole (MCTP)-treated rat is a useful model for the study of certain chronic pulmonary vascular diseases. A single, i.v. administration of a low dose of MCTP causes pneumotoxicity, pulmonary vascular remodeling, sustained increases in pulmonary arterial pressure, and right ventricular hypertrophy in rats. The pulmonary...article 1996
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Cassee, F.R. (author), Arts, J.H.E. (author), Groten, J.P. (author), Feron, V.J. (author)Sensory irritation of formaldehyde (FRM), acrolein (ACR) and acetaldehyde (ACE) as measured by the decrease in breathing frequency (DBF) was studied in male Wistar rats using nose-only exposure. Groups of four rats were exposed to each of the single compounds separately or to mixtures of FRM, ACR and/or ACE. Exposure concentrations of the...article 1996
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Hooftman, R.N. (author), Kuper, C.F. (author), Appelman, L.M. (author), Hoofdgroep Maatschappelijke Technologie TNO (author)The sensitivity of different parameters for the determination of lung injury caused by nitrogen dioxide (NO2) was investigated. Male rats were exposed to concentrations of 0, 4, 10 or 25 ppm NO2 for 6 h/day, for 7, 14 or 21 days. Histopathology of the nasal cavity, larynx, trachea and lungs was compared with the changes in macrophage function...article 1988
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Appelman, L.M. (author), Woutersen, R.A. (author), Feron, V.J. (author), Hooftman, R.N. (author), Notten, W.R.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The effects of exposure pattern on the toxicity of acetaldehyde vapour were investigated in 4-week inhalation studies. Male rats were exposed to 500 or 150 and 110 ppm for 6 h per day/5 days per week. One group of animals was exposed without interruption, the exposure of a second group was interrupted for 1.5 h between the first and second 3-h...article 1986