Searched for: subject:"Lung"
(1 - 20 of 135)

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Zeedijk, H.B. (author), Metaalinstituut TNO (author)
Asbestos bodies and asbestos fibers were found in the lungs of a mesothelioma patient and analysed by electron microscopy. The bodies were normal asbestos bodies with amphibole-asbestos fibers as kernels. The free asbestos fibers, present in the lungs, mainly were chrysotile-asbestos. © 1973 Springer-Verlag. Chemicals/CAS: asbestos, 1332-21-4;...
article 1973
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Broerse, J.J. (author), Radiobiologisch Instituut TNO (author)
Values of the relative biological effectiveness (RBE) of fast neutrons for effect on normal tissue depend not only on the neutron energy and the dose, but also on the type of tissue irradiated. Values of the RBE of 15 MeV neutrons are reviewed for rapidly proliferating rodent tissue, such as mouse bone marrow, mouse intestine and rat skin...
article 1974
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van Putten, L.M. (author), Kram, L.K.J. (author), van Dierendonck, H.H.C. (author), Radiobiologisch Instituut TNO (author)
In studies on a model of induced pulmonary metastasis in mice a tumour host system was analysed which was not affected by immunogenicity of the tumour for the host; neither intensive immunosuppression nor immunization caused a significant change in the quantity of pulmonary metastatic nodules. In contrast the application of cytostatic drugs and...
article 1975
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Kruysse, A. (author), Feron, V.J. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)
The inhalation toxicity of peroxyacetyl nitrate (PAN) was examined in acute (single exposure), subacute (4-wk repeated exposure) and subchronic (13-wk repeated exposure) studies in rats. The 4-hr LC50 was found to be 95 ppm. In the 4-wk study rats were exposed to 0, 0.9, 4.1 or 11.8 ppm PAN vapor for 6 hr/day, 5 days/wk. Exposure to 11.8 ppm...
article 1977
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Maat, B. (author), Radiobiologisch Instituut TNO (author)
Recent data on extrapulmonary colony formation after heparin administration are inconclusive. A systemic study of this topic was undertaken with 4 experimental tumour systems and 2 distinct periods of reduced clotting capacity in rats and mice. I.v. injection of various numbers of tumour cells into i.p. heparinized animals leads to: Significant...
article 1978
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Bleiker, M.A. (author), Styblo, K. (author), Gezondheidsorganisatie TNO (author)
If the trend in risk of tuberculosis infection is estimated from the 1967-1976 data alone (which contain only 6 usable annual figures), the estimate is a decrease of 9.3% annually, a figure substantially lower than the estimate from the 1956-1966 data alone, viz. 13.7%. It is as yet impossible to decide whether or not this represents a real...
article 1978
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van Zwieten, M.J. (author), Solleveld, H.A. (author), Lindsey, J.R. (author), Instituut voor experimentele gerontologie TNO (author)
article 1980
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Maat, B. (author), Radiobiologisch Instituut TNO (author)
Warfarin administered to tumor-bearing mice reduces the number of spontaneous lung metastases. Both macrophage inhibitors silica and carrageenan abolish the warfarin-induced decrease in tumour metastasis, which strongly supports the concept that the antitumour effect of coumarin derivatives is mediated by stimulation of macrophages. The results...
article 1980
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Feron, V.J. (author), van den Heuvel, P.D. (author), Koeter, H.B.W.M. (author), Beems, R.B. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 1980
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Mulder, J.H. (author), Radiobiologisch Instituut TNO (author)
article 1980
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Appelman, L.M. (author), Hendriksen, C.F.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The subacute inhalation toxicity of ??-ethylacrolein was examined in rats by repeated exposure of 4 groups of 10 males and 10 females each to ??-ethylacrolein vapour at concentrations of 0, 2.0, 9.8 or 48.4 ppm, respectively, (6 h/day, 5 days/week) for a period of 13 weeks. The effects at 48.4 ppm were found to include growth retardation, focal...
article 1981
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Feron, V.J. (author), Hendriksen, C.F.M. (author), Speek, A.J. (author), Til, H.P. (author), Spit, B.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A lifespan oral toxicity of vinyl chloride monomer (VCM) was carried out in Wistar rats, using five groups each of 60-80 males and 60-80 females. VCM was administered by incorporating polyvinyl chloride (PVC) powder with a high VCM content into the diet or by gastric intubation of a 10% VCM solution in soya-bean oil. The VCM doses (actual...
article 1981
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Broerse, J.J. (author), Battermann, J.J. (author), Radiobiologisch Instituut TNO (author)
The renewed application of fast neutrons in clinical radiotherapy has been stimulated by fundamental radiobiological findings. The biological effects of high LET radiation, including fast neutrons, are different from those obtained with X-rays in at least three respects: the oxygen enhancement ratio, the sensitivity of cells at different phases...
article 1981
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Feron, V.J. (author), Kruysse, A. (author), Woutersen, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Syrian golden hamsters were exposed to 0 or 2500-1650 ppm acetaldehyde vapour, 7 hr/day, 5 days/week for a period of 52 weeks. A proportion of the animals was given, simultaneously, either intratracheal instillations of benzo(a)pyrene (BP) or subcutaneous injections of diethylnitrosamine (DENA). All treatments were stopped after 52 weeks. The...
article 1982
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Reuzel, P.G.J. (author), Feron, V.J. (author), Spit, B.J. (author), Beems, R.B. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamster or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, food restriction, and...
article 1983
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Reynders, J.B.J. (author), Immel, H.R. (author), Scherrenberg, P.M. (author), Feron, V.J. (author), Beems, R.B. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Two groups of male and female Syrian golden hamsters, of which the trachea was severely injured by electrocoagulation, received 6 weekly intratracheal instillations of benzo[a]pyrene (BaP) + ferric oxide in saline or saline alone. Two comparable groups of hamsters were similarly treated but had an undamaged trachea. The experiment was terminated...
article 1985
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Feron, V.J. (author), Scherrenberg, P.M. (author), Immel, H.R. (author), Spit, B.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Syrian golden hamsters were given intratracheal instillations of glass fibres with or without benzo[a]pyrene suspended in saline, once a fortnight for 52 weeks. The experiment was terminated at week 85. 'Silicotic granulomas' consisting of tightly packed, iron-positive macrophages filled with glass fibres and surrounded by a layer of alveolar...
article 1985
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van Rongen, E. (author), Tan, C. (author), Zurcher, C. (author), Radiobiologisch Instituut TNO (author)
article 1986
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Varekamp, A.E. (author), de Vries, A.J. (author), Hagenbeek, A. (author), Radiobiologisch Instituut TNO (author)
Interstitial pneumonitis (IP) is one of the major complications after allogeneic bone marrow transplantation (incidence: 30 to 50%, fatality rate: 50 to 60%). Cytomegalovirus is associated with 60% of the cases. When no infectious agent can be detected, it is classified as idiopathic IP (IIP). Factors related to IIP are: remission induction...
article 1986
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van Graft, M. (author), Spit, B.J. (author), Immel, H.R. (author), Feron, V.J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
In a one-year serial sacrifice study 10 mg glass fibres (length, 95% ?? 20 ??m, 89% ?? 12 ??m, 58% ?? 5 ??m and 25% ?? 2 ??m; diameter, 88% ?? 1.0 ??m, 60% ?? 0.5 ??m and 31% ??0.25 ??m) suspended in 0.2 ml saline solution were administered to Syrian golden hamsters by a single intratracheal instillation to determine the clearance of the glass...
article 1986
Searched for: subject:"Lung"
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