Searched for: subject:"Lung"
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Voorrips, L.E. (author), Goldbohm, R.A. (author), Verhoeven, D.T.H. (author), van Poppel, G.A.F.C. (author), Sturmans, F. (author), Hermus, R.J.J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Objective: The purpose was to study the association between vegetable and fruit consumption and lung cancer incidence using 1074 cases after 6.3 years of follow-up in the Netherlands Cohort Study. Methods: Dietary intake was assessed using a 150-item food-frequency questionnaire. Multivariate models were used including age, sex, family history...
article 2000
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Godschalk, R.W.L. (author), Moonen, E.J.C. (author), Schilderman, A.E.L. (author), Broekmans, W.M.R. (author), Kleinjans, J.C.S. (author), van Schooten, F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Understanding the kinetics of aromatic-DNA adducts in target tissues and white blood cells (WBC) would enhance the applicability of DNA adducts in WBC as surrogate source of DNA in biomonitoring studies. In the present study, rats were acutely exposed to benzo[a]pyrene (B[a]P; 10 mg/kg body wt) via intratracheal (i.t.), dermal and oral...
article 2000
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van Poppel, G. (author), Verhoeven, D.T.H. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
This paper first gives an overview of the epidemiological data concerning the cancer-preventive effect of brassica vegetables, including cabbages, kale, broccoli, Brussels sprouts, and cauliflower. A protective effect of brassicas against cancer may be plausible due to their relatively high content of glucosinolates. Certain hydrolysis products...
article 2000
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Voorrips, L.E. (author), Goldbohm, R.A. (author), Brants, H.A.M. (author), van Poppel, G.A.F.C. (author), Sturmans, F. (author), Hermus, R.J.J. (author), van den Brandt, P.A. (author)
Many studies have reported inverse associations between vegetable and fruit consumption and lung cancer risk. The aim of the present study was to elucidate the role of several antioxidants and folate in this relationship. In the Netherlands Cohort Study on Diet and Cancer, 58,279 men of ages 55-69 years at baseline in 1986 returned a...
article 2000
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Goldbohm, R.A. (author), Voorrips, L.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
article 2000
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Izeboud, C.A. (author), Monshouwer, M. (author), Witkamp, R.F. (author), van Miert, A.S.J. (author), TNO Voeding (author)
During infection and inflammation drug disposition and hepatic metabolism are markedly affected in mammals. Pro-inflammatory mediators play an important role in the suppression of (cytochrome-P450-mediated) drug metabolism. Inflammatory mediators like cytokines, nitric oxide (NO), reactive oxygen species (ROS) and eicosanoids are released by...
article 2000
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TNO Biomedical Instrumentation (author), Jellema, W.T. (author), Groeneveld, A.B.Johan (author), van Goudoever, J. (author), Wesseling, K.H. (author), Westerhof, N. (author), Lubbers, M.J. (author), Kesecioglu, J. (author), van Lieshout, J.J. (author)
OBJECTIVE: The purposes of this study were to investigate the hemodynamic changes induced by intermittent manual lung hyperinflation (MHI) and to assess if these changes are adverse enough to warrant prohibition of MHI as a routine procedure in the care of patients with septic shock. DESIGN: The study's design was experimental prospective....
article 2000
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Woutersen, R.A. (author), Wolterbeek, A.P.M. (author), Appel, M.J. (author), van den Berg, H. (author), Goldbohm, R.A. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The safety of β-carotene was reassessed by evaluating the relevant literature on the beneficial and adverse effects of β-carotene on cancer and, in particular, by evaluating the results of toxicity studies. β- Carotene appeared neither genotoxic nor reprotoxic or teratogenic, and no signs of organ toxicity have been found in subacute, subchronic...
article 1999
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Dormans, J.A.M.A. (author), Steerenberg, P.A. (author), Arts, J.H.E. (author), van Bree, L. (author), de Klerk, A. (author), Verlaan, A.P.J. (author), Bruijntjes, J.P. (author), Beekhof, P. (author), van Soolingen, D. (author), van Loveren, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In this study the effects of inhalatory exposure to coal fly ash on lung pathology and the immune system in rats were examined. Rats were exposed to 0, 10, 30, or 100 mg/m3 coal fly ash (6 h/day, 5 days/wk) for 4 wk, or to 0 and 100 mg/m3 for 1 wk, and for 1 wk followed by a recovery in clean air of 3 wk. A concentration-related increase in lung...
article 1999
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van Rozendaal, B.A.W.M. (author), van de Lest, C.H.A. (author), van Eijk, M. (author), van Golde, L.M.G. (author), Voorhout, W.F. (author), van Helden, H.P.M. (author), Haagsman, H.P. (author)
Collectins are carbohydrate binding proteins that are implicated in innate host defense. The lung collectins, surfactant proteins A and D (SP-A and SP-D), bind a variety of pathogens in vitro and influence phagocytosis by alveolar macrophages. In this report we show that SP-D binds endotoxin (lipopolysaccharide, LPS) in vivo in a rat model of...
article 1999
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Zoetelief, J. (author), Wagemaker, G. (author), Broerse, J.J. (author), Centrum voor Stralingsbescherming en Dosimetrie TNO (author)
Purpose: To obtain more accurate information on the dose distribution in rhesus monkeys for total body irradiation with orthovoltage X-rays. Materials and methods: Dose measurements were performed with an ionization chamber inside homogeneous cylindrical and rectangular phantoms of various dimensions and in phantoms containing lung-equivalent...
article 1998
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Arts, J.H.E. (author), Kuper, C.F. (author), Spoor, S.M. (author), Bloksma, N. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Local lymph node activation and increased total serum IgE levels are suggested to be predictive parameters of airway hypersensitivity caused by low molecular weight (LMW) chemicals. Whether increases of total serum IgE are indicative of actual induction of specific airway reactions (morphological and functional) after inhalation challenge was...
article 1998
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Aaronson, N.K. (author), Muller, M. (author), Cohen, P.D.A. (author), Essink-Bot, M.-L. (author), Fekkes, M. (author), Sanderman, R. (author), Sprangers, M.A.G. (author), te Velde, A. (author), Verrips, E. (author), TNO Preventie en Gezondheid (author)
The primary objectives of this research were to translate, validate, and generate normative data on the SF-36 Health Survey for use among Dutch- speaking residents of the Netherlands. Translation of the SF-36 into Dutch followed the stepwise, iterative procedures developed by the IQOLA Project. Following extensive pilot testing, the SF-36 was...
article 1998
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Emeis, J.J. (author), Eijnden van den - Schrauwen, Y. (author), van den Hoogen, C.M. (author), de Priester, W. (author), Westmuckett, A. (author), Lupu, F. (author), Gaubius Instituut TNO (author)
In previous studies we have shown that, after stimulation by a receptor ligand such as thrombin, tissue-type plasminogen activator (tPA) and von Willebrand factor (vW(f)) will be acutely released from human umbilical vein endothelial cells (HUVEC). However, the mechanisms involved in the secretion of these two proteins differ in some respects,...
article 1997
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van Loon, A.J.M. (author), Goldbohm, R.A. (author), Kant, I. (author), Swaen, G.M.H. (author), Kremer, A.M. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Preventie en Gezondheid (author)
Study objective - To evaluate the influence of occupational exposure to carcinogens in explaining the association between socioeconomic status and lung cancer. Design - A prospective cohort study. Data on diet, other lifestyle factors, sociodemographic characteristics and job history were collected by means of a self administered questionnaire....
article 1997
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Bos, R. (author), van Leuven, C.J.M. (author), Stolk, J. (author), Hiemstra, P.S. (author), Ronday, H.K. (author), Nieuwenhuizen, W. (author), TNO Preventie en Gezondheid (author)
Upon stimulation, polymorphonuclear leucocytes (PMNs) release potent serine proteases, i.e. elastase, cathepsin C and proteinase 3, which contribute to the degradation of tissue and plasma components. Here, we describe the development of a plasma test to assess PMN-mediated fibrinogenolysis as a biochemical marker for actual PMN-derived...
article 1997
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Zaman, G.J.R. (author), Cnubben, N.H.P. (author), van Bladeren, P.J. (author), Evers, R. (author), Borst, P. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The multidrug resistance protein MRP has been shown to mediate the transport of glutathione S-conjugates across membranes. In this study we demonstrate that the glutathione S-conjugate of the diuretic drug ethacrynic acid, which is an efficient inhibitor of glutathione S-transferases, is a high-affinity substrate and inhibitor of the glutathione...
article 1996
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Kappers, W.A. (author), de Groene, E.M. (author), Kleij, L.A. (author), Witkamp, R.F. (author), Zweers-Zeilmaker, W.M. (author), Feron, V.J. (author), Horbach, G.J. (author), TNO Voeding (author)
1. To study the role of cytochrome P4502C10 in the metabolism of the non-steroidal antiinflammatory drugs (NSAIDs) diclofenac, phenylbutazone, fenoprofen, ibuprofen, flurbiprofen, ketoprofen and naproxen, a cell line was developed stably expressing CYP2C10 cDNA. A retroviral vector construct, containing a human CYP2C10 cDNA, was transfected in...
article 1996
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Gruys, E. (author), Tooten, P.C.J. (author), Kuijpers, M.H.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Amyloid deposits represent frequent histological findings in SPF strains of mice mainly used for toxicological studies. Usually, these are deposits of reactive amyloid (AA-amyloid) derived from the acute phase protein serum amyloid A (SAA). The SAA is an apoprotein of high density lipoprotein (apoSAA). Senescence-accelerated amyloid (ASsam)...
article 1996
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Schultze, A.E. (author), Emeis, J.J. (author), Roth, R.A. (author), Gaubius Instituut TNO (author)
The monocrotaline pyrrole (MCTP)-treated rat is a useful model for the study of certain chronic pulmonary vascular diseases. A single, i.v. administration of a low dose of MCTP causes pneumotoxicity, pulmonary vascular remodeling, sustained increases in pulmonary arterial pressure, and right ventricular hypertrophy in rats. The pulmonary...
article 1996
Searched for: subject:"Lung"
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