Searched for: subject:"Lung"
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van der Heijden, R.A. (author), Morrison, M.C. (author), Sheedfar, F. (author), Mulder, P. (author), Schreurs, M. (author), Hommelberg, P.P.H. (author), Hofker, M.H. (author), Schalkwijk, C. (author), Kleemann, R. (author), Tietge, U.J.F. (author), Koonen, D.P.Y. (author), Heeringa, P. (author)
Background. Naturally occurring substances from the flavanol and anthocyanin family of polyphenols have been proposed to exert beneficial effects in the course of obesity. We hypothesized that their effects on attenuating obesity-induced dyslipidemia as well as the associated inflammatory sequelae especially have health-promoting potential....
article 2016
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Preller, L. (author), van den Bosch, L.M.C. (author), van den Brandt, P.A. (author), Kauppinen, T. (author), Goldbohm, R.A. (author), TNO Kwaliteit van Leven (author)
Objectives: The lung cancer carcinogenicity of crystalline silica dust remains the subject of discussion. Epidemiological evidence is based on occupational cohort studies and population-based case-control studies. The aim of this study was to assess associations between male lung cancer risk and silica exposure in a population-based cohort study...
article 2010
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Mert, A. (author), Klöpping-Ketelaars, I. (author), Bles, W. (author), TNO Defensie en Veiligheid (author)
Motion sickness incidence (MSI) for vertical sinusoidal motion reaches a maximum at 0.167 Hz. Normal breathing frequency is close to this frequency. There is some evidence for synchronization of breathing with this stimulus frequency. If this enforced breathing takes place over a larger frequency range (0.05-0.8 Hz) and whether this contributes...
article 2009
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Arts, J.H.E. (author), Schijf, M.A. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)
Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, the effect of airway irritation by synthetic amorphous silica (SAS) on respiratory allergy to trimellitic anhydride (TMA) was studied. Brown Norway (BN) rats were topically sensitized on day 0 and on day 7,...
article 2008
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Kuper, C.F. (author), Stierum, R.H. (author), Boorsma, A. (author), Schijf, M.A. (author), Prinsen, M. (author), Bruijntjes, J.P. (author), Bloksma, N. (author), Arts, J.H.E. (author), TNO Kwaliteit van Leven (author)
All LMW respiratory allergens known to date can also induce skin allergy in test animals. The question here was if in turn skin allergens can induce allergy in the respiratory tract. Respiratory allergy was tested in Th2-prone Brown Norway (BN) rats by dermal sensitization with the contact allergen dinitrochlorobenzene (DNCB; 1%, day 0; 0.5%,...
article 2008
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Rusch, G.M. (author), Bowden, A.M. (author), Muijser, H. (author), Arts, J. (author), TNO Kwaliteit van Leven (author)
The objectives of this study were to examine the respiratory irritancy of boron trifluoride (BF3) and fluorosulfonic acid (FSA) following acute inhalation exposure. Testing was conducted using groups of 10 male and 10 female rats (BF3) or groups of 6 male rats (FSA). Rats were exposed for a single 4-h period (BF3) or a single 1-h period (FSA)...
article 2008
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Hissink, A.M. (author), Krüse, J. (author), Kulig, B.M. (author), Verwei, M. (author), Muijser, H. (author), Salmon, F. (author), Leenheers, L.H. (author), Owen, D.E. (author), Lammers, J.H.C.M. (author), Freidig, A.P. (author), McKee, R.H. (author), TNO Kwaliteit van Leven (author)
As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted in rats and human volunteers in which acute CNS effects were measured and toxicokinetic data were collected. A complex hydrocarbon solvent, white...
article 2007
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Pronk, A. (author), Preller, L. (author), Raulf-Heimsoth, M. (author), Jonkers, I.C.L. (author), Lammers, J.-W. (author), Wouters, I.M. (author), Doekes, G. (author), Wisnewski, A.V. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Rationale: Associations between oligomeric isocyanate exposure, sensitization, and respiratory disease have received little attention, despite the extensive use of isocyanate oligomers. Objectives: To investigate exposure-response relationships of respiratory symptoms and sensitization in a large population occupationally exposed to isocyanate...
article 2007
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Valstar, D.L. (author), Schijf, M.A. (author), Arts, J.H.E. (author), Kuper, C.F. (author), Nijkamp, F.P. (author), Storm, G. (author), Bloksma, N. (author), Henricks, P.A.J. (author), TNO Kwaliteit van Leven (author)
Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter these inhaled compounds and were previously shown to affect TMA-induced asthma-like symptoms in the Brown Norway rat (Valstar et al., Toxicol. Appl....
article 2006
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Oudshoorn, J.H. (author), Lecluse, A.L.Y. (author), van den Berg, R. (author), Vaes, W.H.J. (author), van der Laag, J. (author), Houwen, R.H.J. (author), TNO Kwaliteit van Leven (author)
OBJECTIVES: Coenzyme Q10 (CoQ10) is an effective lipophilic antioxidant and protects against lipid peroxidation by scavenging radicals. Patients with cystic fibrosis generally have fat malabsorption; thus, we hypothesized that overall plasma CoQ10 concentration in pediatric patients with cystic fibrosis might be diminished. Because these...
article 2006
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Valstar, D.L. (author), Schijf, M.A. (author), Nijkamp, F.P. (author), Storm, G. (author), Arts, J.H.E. (author), Kuper, C.F. (author), Bloksma, N. (author), Henricks, P.A.J. (author), TNO Kwaliteit van Leven (author)
Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter inhaled compounds. These cells can produce many different mediators that have a putative role in asthma. In this study, we examined the role of AMs in lung...
article 2006
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de Boer, V.C.J. (author), van Schothorst, E.M. (author), Dihal, A.A. (author), van der Woude, H. (author), Arts, I.C.W. (author), Rietjens, I.M.C.M. (author), Hollman, P.C.H. (author), Keijer, J. (author), TNO Kwaliteit van Leven (author)
Dietary quercetin intake is suggested to be health promoting, but this assumption is mainly based on mechanistic studies performed in vitro. Previously, we identified rat lung as a quercetin target tissue. To assess relevant in vivo health effects of quercetin, we analyzed mechanisms of effect in rat lungs of a chronic (41 weeks) 1% quercetin...
article 2006
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Portengen, L. (author), Preller, L. (author), Tielen, M. (author), Doekes, G. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Background: Recent studies have reported a low prevalence of atopic sensitization and respiratory allergy in children growing up on farms. Objectives: We sought to evaluate the dose-response relationship between endotoxin and atopic sensitization in adult farmers and to assess the effect on respiratory health outcomes. Methods: Data on endotoxin...
article 2005
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Tjoe Nij, E. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Objectives: The aim of this study was to assess the magnitude of the silicosis and cancer risk among construction workers. Methods: In 1998, 1335 of 4173 invited construction workers with expected high cumulative exposure to quartz were studied for early signs of silicosis. In 2002 the study was repeated for 96 persons. Exposure measurements...
article 2005
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de Boer, V.C.J. (author), Dihal, A.A. (author), van der Woude, H. (author), Arts, I.C.W. (author), Wolffram, S. (author), Alink, G.M. (author), Rietjens, I.M.C.M. (author), Keijer, J. (author), Hollman, P.C.H. (author), TNO Kwaliteit van Leven (author)
Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health. Claims that quercetin has biological effects are based mainly on in vitro studies with quercetin aglycone. However, quercetin is rapidly metabolized, and we have little knowledge of its availability to tissues. To assess the long-term tissue distribution...
article 2005
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Freudenheim, J.L. (author), Ritz, J. (author), Smith-Warner, S.A. (author), Albanes, D. (author), Bandera, E.V. (author), van den Brandt, P.A. (author), Colditz, G. (author), Feskanich, D. (author), Goldbohm, R.A. (author), Harnack, L. (author), Miller, A.B. (author), Rimm, E. (author), Rohan, T.E. (author), Sellers, T.A. (author), Virtamo, J. (author), Willett, W.C. (author), Hunter, D.J. (author), TNO Kwaliteit van Leven (author)
Background: Although smoking is the primary cause of lung cancer, much is unknown about lung cancer etiology, including risk determinants for nonsmokers and modifying factors for smokers. Objective: We hypothesized that alcohol consumption contributes to lung cancer risk. Design: We conducted a pooled analysis using standardized exposure and...
article 2005
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Ploemen, J.P.H.T.M. (author), Kelder, J. (author), Hafmans, T. (author), van de Sandt, H. (author), van Burgsteden, J.A. (author), Salemink, P.J.M. (author), van Esch, E. (author), TNO Voeding (author)
Several cationic amphiphilic compounds are known to induce phospholipidosis, a condition primarily characterized by excessive accumulation of phospholipids in different cell types, giving the affected cells a finely foamy appearance. Excessive storage of lamellar membranous intralysosomal inclusion bodies is the hallmark for phospholipidosis on...
article 2004
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Arts, J.H.E. (author), de Koning, M.W. (author), Bloksma, N. (author), Kuper, C.F. (author), TNO Voeding (author)
The present study investigated whether airway responses of sensitized rats to trimellitic anhydride (TMA) were concentration dependent and whether these were related to irritation by TMA. Groups of BN and Wistar rats were sensitized by two dermal applications of TMA (50% w/v, followed by 25% w/v in vehicle). Controls received vehicle (acetone...
article 2004
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van Ommen, B. (author), de Bie, A.T.H.J. (author), Bär, A. (author), TNO Voeding (author)
The absorption, disposition, metabolism, and excretion of uniformly 14C-labeled α-cyclodextrin (14C-α-CD) was examined in four separate experiments with Wistar rats. In Experiment 1, 14C-α-CD (25μCi, 50mg/kg bw) was administered intravenously to four male and four female conventional rats. In Experiment 2, 14C-α-CD (25μCi, 200mg/kg bw) was given...
article 2004
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Hoek, G. (author), Brunekreef, B. (author), Goldbohm, S. (author), Fischer, P. (author), van den Brandt, P.A. (author)
Background: Long-term exposure to particulate matter air pollution has been associated with increased cardiopulmonary mortality in the USA. We aimed to assess the relation between traffic-related air pollution and mortality in participants of the Netherlands Cohort study on Diet and Cancer (NLCS), an ongoing study. Methods: We investigated a...
article 2002
Searched for: subject:"Lung"
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