Searched for: subject:"Lung"
(1 - 20 of 40)

Pages

document
Kuper, C.F. (author), Heijne, W.H. (author), Dansen, M. (author), Verhoeckx, K.C. (author), Boorsma, A. (author), Radonjic, M. (author), Bruijntjes, J. (author), Stierum, R. (author), Muijser, H. (author), Arts, J.H. (author), TNO Kwaliteit van Leven (author)
To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway rats. Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m(3)...
article 2008
document
Arts, J.H.E. (author), Schijf, M.A. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)
Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, the effect of airway irritation by synthetic amorphous silica (SAS) on respiratory allergy to trimellitic anhydride (TMA) was studied. Brown Norway (BN) rats were topically sensitized on day 0 and on day 7,...
article 2008
document
Kuper, C.F. (author), Stierum, R.H. (author), Boorsma, A. (author), Schijf, M.A. (author), Prinsen, M. (author), Bruijntjes, J.P. (author), Bloksma, N. (author), Arts, J.H.E. (author), TNO Kwaliteit van Leven (author)
All LMW respiratory allergens known to date can also induce skin allergy in test animals. The question here was if in turn skin allergens can induce allergy in the respiratory tract. Respiratory allergy was tested in Th2-prone Brown Norway (BN) rats by dermal sensitization with the contact allergen dinitrochlorobenzene (DNCB; 1%, day 0; 0.5%,...
article 2008
document
Punt, A. (author), Freidig, A.P. (author), Delatour, T. (author), Scholz, G. (author), Boersma, M.G. (author), Schilter, B. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)
The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene estragole in rat based on in vitro metabolic parameters determined using relevant tissue fractions, in silico derived partition coefficients, and physiological parameters derived from the literature. The model consists of eight compartments including...
article 2008
document
Rusch, G.M. (author), Bowden, A.M. (author), Muijser, H. (author), Arts, J. (author), TNO Kwaliteit van Leven (author)
The objectives of this study were to examine the respiratory irritancy of boron trifluoride (BF3) and fluorosulfonic acid (FSA) following acute inhalation exposure. Testing was conducted using groups of 10 male and 10 female rats (BF3) or groups of 6 male rats (FSA). Rats were exposed for a single 4-h period (BF3) or a single 1-h period (FSA)...
article 2008
document
Hissink, A.M. (author), Krüse, J. (author), Kulig, B.M. (author), Verwei, M. (author), Muijser, H. (author), Salmon, F. (author), Leenheers, L.H. (author), Owen, D.E. (author), Lammers, J.H.C.M. (author), Freidig, A.P. (author), McKee, R.H. (author), TNO Kwaliteit van Leven (author)
As part of a project designed to develop a framework for extrapolating acute central nervous system (CNS) effects of hydrocarbon solvents in animals to humans, experimental studies were conducted in rats and human volunteers in which acute CNS effects were measured and toxicokinetic data were collected. A complex hydrocarbon solvent, white...
article 2007
document
Sweeney, R.E. (author), Langenberg, J.P. (author), Maxwell, D.M. (author), TNO Defensie en Veiligheid (author)
A physiologically based pharmacokinetic (PB/PK) model has been developed in advanced computer simulation language (ACSL) to describe blood and tissue concentration-time profiles of the C(±)P(-) stereoisomers of soman after inhalation, subcutaneous and intravenous exposures at low (0.8-1.0 × LD50), medium (2-3 × LD50) and high (6 × LD50) levels...
article 2006
document
Valstar, D.L. (author), Schijf, M.A. (author), Arts, J.H.E. (author), Kuper, C.F. (author), Nijkamp, F.P. (author), Storm, G. (author), Bloksma, N. (author), Henricks, P.A.J. (author), TNO Kwaliteit van Leven (author)
Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter these inhaled compounds and were previously shown to affect TMA-induced asthma-like symptoms in the Brown Norway rat (Valstar et al., Toxicol. Appl....
article 2006
document
Valstar, D.L. (author), Schijf, M.A. (author), Nijkamp, F.P. (author), Storm, G. (author), Arts, J.H.E. (author), Kuper, C.F. (author), Bloksma, N. (author), Henricks, P.A.J. (author), TNO Kwaliteit van Leven (author)
Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter inhaled compounds. These cells can produce many different mediators that have a putative role in asthma. In this study, we examined the role of AMs in lung...
article 2006
document
de Boer, V.C.J. (author), van Schothorst, E.M. (author), Dihal, A.A. (author), van der Woude, H. (author), Arts, I.C.W. (author), Rietjens, I.M.C.M. (author), Hollman, P.C.H. (author), Keijer, J. (author), TNO Kwaliteit van Leven (author)
Dietary quercetin intake is suggested to be health promoting, but this assumption is mainly based on mechanistic studies performed in vitro. Previously, we identified rat lung as a quercetin target tissue. To assess relevant in vivo health effects of quercetin, we analyzed mechanisms of effect in rat lungs of a chronic (41 weeks) 1% quercetin...
article 2006
document
de Boer, V.C.J. (author), Dihal, A.A. (author), van der Woude, H. (author), Arts, I.C.W. (author), Wolffram, S. (author), Alink, G.M. (author), Rietjens, I.M.C.M. (author), Keijer, J. (author), Hollman, P.C.H. (author), TNO Kwaliteit van Leven (author)
Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health. Claims that quercetin has biological effects are based mainly on in vitro studies with quercetin aglycone. However, quercetin is rapidly metabolized, and we have little knowledge of its availability to tissues. To assess the long-term tissue distribution...
article 2005
document
Ploemen, J.P.H.T.M. (author), Kelder, J. (author), Hafmans, T. (author), van de Sandt, H. (author), van Burgsteden, J.A. (author), Salemink, P.J.M. (author), van Esch, E. (author), TNO Voeding (author)
Several cationic amphiphilic compounds are known to induce phospholipidosis, a condition primarily characterized by excessive accumulation of phospholipids in different cell types, giving the affected cells a finely foamy appearance. Excessive storage of lamellar membranous intralysosomal inclusion bodies is the hallmark for phospholipidosis on...
article 2004
document
Arts, J.H.E. (author), de Koning, M.W. (author), Bloksma, N. (author), Kuper, C.F. (author), TNO Voeding (author)
The present study investigated whether airway responses of sensitized rats to trimellitic anhydride (TMA) were concentration dependent and whether these were related to irritation by TMA. Groups of BN and Wistar rats were sensitized by two dermal applications of TMA (50% w/v, followed by 25% w/v in vehicle). Controls received vehicle (acetone...
article 2004
document
van Ommen, B. (author), de Bie, A.T.H.J. (author), Bär, A. (author), TNO Voeding (author)
The absorption, disposition, metabolism, and excretion of uniformly 14C-labeled α-cyclodextrin (14C-α-CD) was examined in four separate experiments with Wistar rats. In Experiment 1, 14C-α-CD (25μCi, 50mg/kg bw) was administered intravenously to four male and four female conventional rats. In Experiment 2, 14C-α-CD (25μCi, 200mg/kg bw) was given...
article 2004
document
Arts, J.H.E. (author), Bloksma, N. (author), Leusink-Muis, T. (author), Kuper, C.F. (author)
Occupational exposure to low-molecular-weight (LMW) allergens such as acid anhydrides can result in occupational asthma, an allergic disease characterized by episodic airway obstruction, airways inflammation, and non specific airways hyperresponsiveness. Since LMW irritants can provoke rather similar effects and since most, if not all, LMW...
article 2003
document
Cassee, F.R. (author), Muijser, H. (author), Duistermaat, E. (author), Freijer, J.J. (author), Geerse, E.K.B. (author), Marijnissen, J.C.M. (author), Arts, J.H.E. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The relative importance of the three particulate matter (PM) size fractions in ambient air, i.e. coarse (2.5-10 μm), fine (0.1-2.5 μm) and ultrafine (< 0.1 μm) fractions, on the induction of adverse health effects is still unknown. Moreover, there is no straightforward relationship between ambient concentration levels, exposure (external dose)...
article 2002
document
Cassee, F.R. (author), Arts, J.H.E. (author), Fokkens, P.H.B. (author), Spoor, S.M. (author), Boere, A.J.F. (author), van Bree, L. (author), Dormans, J.A.M.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In the present study the effects of a 3-day inhalation exposure to model compounds for ambient particulate matter were investigated: ammonium bisulfate, ammonium ferrosulfate, and ammonium nitrate, all components of the secondary aerosol fraction of ambient particulate matter (PM), and carbon black (CB, model aerosol for primary PM). The...
article 2002
document
Feron, V.J. (author), Kittel, B. (author), Kuper, C.F. (author), Ernst, H. (author), Rittinghausen, S. (author), Muhle, H. (author), Koch, W. (author), Gamer, A. (author), Mallett, A.K. (author), Hoffmann, H.D. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
Two independent bioassays are available which have examined the potential carcinogenicity of monomeric and polymeric methylene diphenyl diisocyanate (MDI) following long-term inhalation exposure in rats. These studies are not directly comparable, however, due to differences in design and conduct of the in-life phase, and differences in...
article 2001
document
Arts, J.H.E. (author), de Koning, M.W. (author), Bloksma, N. (author), Kuper, C.F. (author), TNO Voeding (author)
Several acid anhydrides are known for their sensitizing and irritative properties. Since both irritation and respiratory allergy can cause changes of lung function, proper testing of allergen-dependent effects on the respiratory tract requires knowledge of the respiratory irritant effects. To study the latter effects, groups of female Brown...
article 2001
document
Godschalk, R.W.L. (author), Moonen, E.J.C. (author), Schilderman, A.E.L. (author), Broekmans, W.M.R. (author), Kleinjans, J.C.S. (author), van Schooten, F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Understanding the kinetics of aromatic-DNA adducts in target tissues and white blood cells (WBC) would enhance the applicability of DNA adducts in WBC as surrogate source of DNA in biomonitoring studies. In the present study, rats were acutely exposed to benzo[a]pyrene (B[a]P; 10 mg/kg body wt) via intratracheal (i.t.), dermal and oral...
article 2000
Searched for: subject:"Lung"
(1 - 20 of 40)

Pages