Searched for: subject:"Lung"
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van der Valk, E.S. (author), Smans, L.C.C.J. (author), Hofstetter, H. (author), Stubbe, J.H. (author), de Vries, M. (author), Backx, F.J.G. (author), Hermus, A.R.M.M. (author), Zelissen, P.M.J. (author)
Background: Health-related quality of life in patients with Addison's disease has been assessed in various European countries, indicating a reduced quality of life. However, no studies have addressed the impact of Addison's disease on physical activity. Objective: The aim of this study was to investigate the quality of life in Dutch patients...
article 2016
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Tan, E. (author), Boessen, R. (author), Fishwick, D. (author), Klein Entink, R. (author), Meijster, T. (author), Pronk, A. (author), van Duuren-Stuurman, B. (author), Warren, N. (author)
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that is thought to affect over one million people in Great Britain. The main factor contributing to the development of COPD is tobacco smoke. This paper presents a microsimulation model for the development of COPD, incorporating population dynamics and trends in smoking. The...
article 2015
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Groothuis-Oudshoorn, C.G.M. (author), Chorus, A.M.J. (author), Verrips, G.H.W. (author), Detmar, S.B. (author)
BACKGROUND: The London Handicap Scale (LHS) was found to be a valid and reliable scale for measuring participation restrictions in adults. OBJECTIVE: This paper describes the development and assesses the construct-related validity of a Dutch version of the London Handicap Scale (DLHS). METHODS: The DLHS was tested in 798 adults (mean age: 50.7...
article 2015
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Pronk, A. (author), Preller, L. (author), Doekes, G. (author), Wouters, I.M. (author), Rooijackers, J. (author), Lammers, J.-W. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Associations have been observed between exposure to isocyanates, consisting mainly of oligomers, and respiratory symptoms and isocyanate specific sensitisation in spray painters. The aim of the present study was to assess associations between isocyanate exposure and more objective respiratory effect measures such as bronchial hyperresponsiveness...
article 2009
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Hogervorst, J.G.F. (author), Schouten, L.J. (author), Konings, E.J.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Background : Acrylamide is a probable human carcinogen that is present in several heat-treated foods. In epidemiological studies, positive associations between dietary acrylamide intake and the risks of endometrial, ovarian, estrogen receptor-positive breast, and renal cell cancers have been observed. The association between dietary acrylamide...
article 2009
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Kuper, C.F. (author), Heijne, W.H. (author), Dansen, M. (author), Verhoeckx, K.C. (author), Boorsma, A. (author), Radonjic, M. (author), Bruijntjes, J. (author), Stierum, R. (author), Muijser, H. (author), Arts, J.H. (author), TNO Kwaliteit van Leven (author)
To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway rats. Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m(3)...
article 2008
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Beelen, R. (author), Hoek, G. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Fischer, P. (author), Schouten, L.J. (author), Jerrett, M. (author), Hughes, E. (author), Armstrong, B. (author), Brunekreef, B. (author), TNO Kwaliteit van Leven (author)
Background: Several studies have found an effect on mortality of between-city contrasts in long-term exposure to air pollution. The effect of within-city contrasts is still poorly understood. Objectives: We studied the association between long-term exposure to traffic-related air pollution and mortality in a Dutch cohort. Methods: We used data...
article 2008
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Zeegers, M.P. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)
Familial clustering of cancer is expected to occur at practically all anatomical sites. However, few studies have had sufficient size to investigate different sites simultaneously and with adjustment for confounders. We evaluated familial clustering in the Netherlands Cohort Study in which 120,852 men and women, aged 55-69 years in 1986 were...
article 2008
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Arts, J.H.E. (author), Schijf, M.A. (author), Kuper, C.F. (author), TNO Kwaliteit van Leven (author)
Irritant-induced inflammation of the airways may aggravate respiratory allergy induced by chemical respiratory allergens. Therefore, the effect of airway irritation by synthetic amorphous silica (SAS) on respiratory allergy to trimellitic anhydride (TMA) was studied. Brown Norway (BN) rats were topically sensitized on day 0 and on day 7,...
article 2008
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Kuper, C.F. (author), Stierum, R.H. (author), Boorsma, A. (author), Schijf, M.A. (author), Prinsen, M. (author), Bruijntjes, J.P. (author), Bloksma, N. (author), Arts, J.H.E. (author), TNO Kwaliteit van Leven (author)
All LMW respiratory allergens known to date can also induce skin allergy in test animals. The question here was if in turn skin allergens can induce allergy in the respiratory tract. Respiratory allergy was tested in Th2-prone Brown Norway (BN) rats by dermal sensitization with the contact allergen dinitrochlorobenzene (DNCB; 1%, day 0; 0.5%,...
article 2008
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Punt, A. (author), Freidig, A.P. (author), Delatour, T. (author), Scholz, G. (author), Boersma, M.G. (author), Schilter, B. (author), van Bladeren, P.J. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)
The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene estragole in rat based on in vitro metabolic parameters determined using relevant tissue fractions, in silico derived partition coefficients, and physiological parameters derived from the literature. The model consists of eight compartments including...
article 2008
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Beelen, R. (author), Hoek, G. (author), van den Brandt, P.A. (author), Goldbohm, R.A. (author), Fischer, P. (author), Schouten, L.J. (author), Armstrong, B. (author), Brunekreef, B. (author), TNO Kwaliteit van Leven (author)
Background: Most studies on the association between lung cancer and air pollution have investigated mortality. There have been few studies of lung cancer incidence. Methods: We used data from the ongoing Netherlands Cohort Study on Diet and Cancer for 114,378 subjects with follow-up from September 1986 to December 1997. Exposure to black smoke,...
article 2008
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Rusch, G.M. (author), Bowden, A.M. (author), Muijser, H. (author), Arts, J. (author), TNO Kwaliteit van Leven (author)
The objectives of this study were to examine the respiratory irritancy of boron trifluoride (BF3) and fluorosulfonic acid (FSA) following acute inhalation exposure. Testing was conducted using groups of 10 male and 10 female rats (BF3) or groups of 6 male rats (FSA). Rats were exposed for a single 4-h period (BF3) or a single 1-h period (FSA)...
article 2008
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Pronk, A. (author), Preller, L. (author), Raulf-Heimsoth, M. (author), Jonkers, I.C.L. (author), Lammers, J.-W. (author), Wouters, I.M. (author), Doekes, G. (author), Wisnewski, A.V. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
Rationale: Associations between oligomeric isocyanate exposure, sensitization, and respiratory disease have received little attention, despite the extensive use of isocyanate oligomers. Objectives: To investigate exposure-response relationships of respiratory symptoms and sensitization in a large population occupationally exposed to isocyanate...
article 2007
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Valstar, D.L. (author), Schijf, M.A. (author), Arts, J.H.E. (author), Kuper, C.F. (author), Nijkamp, F.P. (author), Storm, G. (author), Bloksma, N. (author), Henricks, P.A.J. (author), TNO Kwaliteit van Leven (author)
Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter these inhaled compounds and were previously shown to affect TMA-induced asthma-like symptoms in the Brown Norway rat (Valstar et al., Toxicol. Appl....
article 2006
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Oudshoorn, J.H. (author), Lecluse, A.L.Y. (author), van den Berg, R. (author), Vaes, W.H.J. (author), van der Laag, J. (author), Houwen, R.H.J. (author), TNO Kwaliteit van Leven (author)
OBJECTIVES: Coenzyme Q10 (CoQ10) is an effective lipophilic antioxidant and protects against lipid peroxidation by scavenging radicals. Patients with cystic fibrosis generally have fat malabsorption; thus, we hypothesized that overall plasma CoQ10 concentration in pediatric patients with cystic fibrosis might be diminished. Because these...
article 2006
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Verhaagh, S. (author), de Jong, E. (author), Goudsmit, J. (author), Lecollinet, S. (author), Gillissen, G. (author), de Vries, M. (author), van Leuven, K. (author), Que, I. (author), Ouwehand, K. (author), Mintardjo, R. (author), Weverling, G.J. (author), Radošević, K. (author), Richardson, J. (author), Eloit, M. (author), Lowik, C. (author), Quax, P. (author), Havenga, M. (author), TNO Kwaliteit van Leven (author)
Wild-type strains of mice do not express CD46, a high-affinity receptor for human group B adenoviruses including type 35. Therefore, studies performed to date in mice using replication-incompetent Ad35 (rAd35) vaccine carriers may underestimate potency or result in altered vector distribution. Here, it is reported that CD46 transgenic mice (MYII...
article 2006
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Kremer, A.M. (author), Pal, T.M. (author), Keimpema, A.R.J. (author), TNO Kwaliteit van Leven (author)
Objectives: The aim was to gain insight into work experiences and problems of subjects with chronic obstructive pulmonary disease (COPD) to develop more effective guidelines for preventing work disability and work loss. Methods: A total of 617 patients aged 45-60, recruited from pulmonary outpatient clinics and general practices, completed a...
article 2006
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Valstar, D.L. (author), Schijf, M.A. (author), Nijkamp, F.P. (author), Storm, G. (author), Arts, J.H.E. (author), Kuper, C.F. (author), Bloksma, N. (author), Henricks, P.A.J. (author), TNO Kwaliteit van Leven (author)
Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter inhaled compounds. These cells can produce many different mediators that have a putative role in asthma. In this study, we examined the role of AMs in lung...
article 2006
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Vrijlandt, E.J.L.E. (author), Gerritsen, J. (author), Boezen, H.M. (author), Duiverman, E.J. (author), Hille, E.T.M. (author), de Groot, C.H. (author), Kloosterboer-Boerrigter, H. (author), den Ouden, A.L. (author), Rijpstra, A. (author), Verloove-Vanhorick, S.P. (author), Vogelaar, J.A. (author), Kok, J.H. (author), Ilsen, A. (author), van der Lans, M. (author), van der Boelen - Loo, W.J.C. (author), Lundqvist, T. (author), Heymans, H.S.A. (author), Geven, W.B. (author), Duiverman, M.L. (author), Geven, L.I. (author), Mulder, A.L.M. (author), Gerver, A. (author), Kollée, L.A.A. (author), Reijmers, L. (author), Sonnemans, R. (author), Wit, J.M. (author), Dekker, F.W. (author), Finken, M.J.J. (author), Weisglas-Kuperus, N. (author), Keijzer-Veen, M.G. (author), van der Heijden, A.J. (author), van Goudoever, J.B. (author), van Weissenbruch, M.M. (author), Cranendonk, A. (author), van de Delemarre - Waal, H.A. (author), de Groot, L. (author), Samsom, J.F. (author), de Vries, L.S. (author), Rademaker, K.J. (author), Moerman, E. (author), Voogsgeerd, M. (author), de Kleine, M.J.K. (author), Andriessen, P. (author), van Dielissen - Helvoirt, C.C.M. (author), Mohamed, I. (author), van Straaten, H.L.M. (author), Baerts, W. (author), Veneklaas Slots-Kloosterboer, G.W. (author), Tuller-Pikkemaat, E.M.J. (author), Ens-Dokkum, M.H. (author), van Steenbrugge, G.J. (author), TNO Kwaliteit van Leven (author)
Objective: To study the prevalence of respiratory and atopic symptoms in (young) adults born prematurely, differences between those who did and did not develop Bronchopulmonary Disease (BPD) at neonatal age and differences in respiratory health between males and females. Methods: Design: Prospective cohort study. Setting: Nation wide follow-up...
article 2005
Searched for: subject:"Lung"
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