Searched for: subject:"Lung"
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Kuper, C.F. (author), Heijne, W.H. (author), Dansen, M. (author), Verhoeckx, K.C. (author), Boorsma, A. (author), Radonjic, M. (author), Bruijntjes, J. (author), Stierum, R. (author), Muijser, H. (author), Arts, J.H. (author), TNO Kwaliteit van Leven (author)
To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway rats. Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m(3)...
article 2008
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Cassee, F.R. (author), Muijser, H. (author), Duistermaat, E. (author), Freijer, J.J. (author), Geerse, E.K.B. (author), Marijnissen, J.C.M. (author), Arts, J.H.E. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The relative importance of the three particulate matter (PM) size fractions in ambient air, i.e. coarse (2.5-10 μm), fine (0.1-2.5 μm) and ultrafine (< 0.1 μm) fractions, on the induction of adverse health effects is still unknown. Moreover, there is no straightforward relationship between ambient concentration levels, exposure (external dose)...
article 2002
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Reichl, F.X. (author), Walther, U.I. (author), Durner, J. (author), Kehe, K. (author), Hickel, R. (author), Kunzelmann, K.H. (author), Spahl, W. (author), Hume, W.R. (author), Benschop, H.P. (author), Forth, W. (author)
Objective: The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA), as well as mercuric chloride (HgCl2) and methylmercury chloride (MeHgCl) was investigated on the release of lactatedehydrogenase (LDH) from alveolar epithelial lung cell lines in vitro. Methods: The confluent cell...
article 2001
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van Rozendaal, B.A.W.M. (author), van de Lest, C.H.A. (author), van Eijk, M. (author), van Golde, L.M.G. (author), Voorhout, W.F. (author), van Helden, H.P.M. (author), Haagsman, H.P. (author)
Collectins are carbohydrate binding proteins that are implicated in innate host defense. The lung collectins, surfactant proteins A and D (SP-A and SP-D), bind a variety of pathogens in vitro and influence phagocytosis by alveolar macrophages. In this report we show that SP-D binds endotoxin (lipopolysaccharide, LPS) in vivo in a rat model of...
article 1999
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Zwart, A. (author), Arts, J.H.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Breathing pattern and lung mechanical parameters were measured in 7 female Wistar rats (ca. 200 g) during exposure to 1.0 (n = 5) or 1.3 (n = 2) ppm ozone in air for 2 h and during a 2-h post-exposure observation period. Changes in breathing pattern showed a gradual decrease from 3 to 2 Hz at constant minute ventilation during the first hour of...
article 1994
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Tranquille, N. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The acute release of tissue-type plasminogen activator (t-PA) was studied in perfused rat hindlegs. Pretreatment of rats with the protein synthesis inhibitor cycloheximide (2 mg/kg) at 1, 3 or 5 h prior to perfusion of rat hindlegs did not influence the amount of t-PA released by platelet-activating factor (20 nM) or bradykinin (1 μM). The...
article 1989
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Hooftman, R.N. (author), Kuper, C.F. (author), Appelman, L.M. (author), Hoofdgroep Maatschappelijke Technologie TNO (author)
The sensitivity of different parameters for the determination of lung injury caused by nitrogen dioxide (NO2) was investigated. Male rats were exposed to concentrations of 0, 4, 10 or 25 ppm NO2 for 6 h/day, for 7, 14 or 21 days. Histopathology of the nasal cavity, larynx, trachea and lungs was compared with the changes in macrophage function...
article 1988
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van Rongen, E. (author), Tan, C. (author), Zurcher, C. (author), Radiobiologisch Instituut TNO (author)
article 1986
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Varekamp, A.E. (author), de Vries, A.J. (author), Hagenbeek, A. (author), Radiobiologisch Instituut TNO (author)
Interstitial pneumonitis (IP) is one of the major complications after allogeneic bone marrow transplantation (incidence: 30 to 50%, fatality rate: 50 to 60%). Cytomegalovirus is associated with 60% of the cases. When no infectious agent can be detected, it is classified as idiopathic IP (IIP). Factors related to IIP are: remission induction...
article 1986
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van Graft, M. (author), Spit, B.J. (author), Immel, H.R. (author), Feron, V.J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
In a one-year serial sacrifice study 10 mg glass fibres (length, 95% ?? 20 ??m, 89% ?? 12 ??m, 58% ?? 5 ??m and 25% ?? 2 ??m; diameter, 88% ?? 1.0 ??m, 60% ?? 0.5 ??m and 31% ??0.25 ??m) suspended in 0.2 ml saline solution were administered to Syrian golden hamsters by a single intratracheal instillation to determine the clearance of the glass...
article 1986
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Zwart, A. (author), Luijendijk, S.C.M. (author), de Vries, W.R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
article 1986
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Appelman, L.M. (author), Woutersen, R.A. (author), Feron, V.J. (author), Hooftman, R.N. (author), Notten, W.R.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects of exposure pattern on the toxicity of acetaldehyde vapour were investigated in 4-week inhalation studies. Male rats were exposed to 500 or 150 and 110 ppm for 6 h per day/5 days per week. One group of animals was exposed without interruption, the exposure of a second group was interrupted for 1.5 h between the first and second 3-h...
article 1986
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Reynders, J.B.J. (author), Immel, H.R. (author), Scherrenberg, P.M. (author), Feron, V.J. (author), Beems, R.B. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Two groups of male and female Syrian golden hamsters, of which the trachea was severely injured by electrocoagulation, received 6 weekly intratracheal instillations of benzo[a]pyrene (BaP) + ferric oxide in saline or saline alone. Two comparable groups of hamsters were similarly treated but had an undamaged trachea. The experiment was terminated...
article 1985
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Feron, V.J. (author), Scherrenberg, P.M. (author), Immel, H.R. (author), Spit, B.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Syrian golden hamsters were given intratracheal instillations of glass fibres with or without benzo[a]pyrene suspended in saline, once a fortnight for 52 weeks. The experiment was terminated at week 85. 'Silicotic granulomas' consisting of tightly packed, iron-positive macrophages filled with glass fibres and surrounded by a layer of alveolar...
article 1985
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Reuzel, P.G.J. (author), Feron, V.J. (author), Spit, B.J. (author), Beems, R.B. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamster or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, food restriction, and...
article 1983
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Feron, V.J. (author), Kruysse, A. (author), Woutersen, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Syrian golden hamsters were exposed to 0 or 2500-1650 ppm acetaldehyde vapour, 7 hr/day, 5 days/week for a period of 52 weeks. A proportion of the animals was given, simultaneously, either intratracheal instillations of benzo(a)pyrene (BP) or subcutaneous injections of diethylnitrosamine (DENA). All treatments were stopped after 52 weeks. The...
article 1982
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Appelman, L.M. (author), Hendriksen, C.F.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The subacute inhalation toxicity of ??-ethylacrolein was examined in rats by repeated exposure of 4 groups of 10 males and 10 females each to ??-ethylacrolein vapour at concentrations of 0, 2.0, 9.8 or 48.4 ppm, respectively, (6 h/day, 5 days/week) for a period of 13 weeks. The effects at 48.4 ppm were found to include growth retardation, focal...
article 1981
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Feron, V.J. (author), Hendriksen, C.F.M. (author), Speek, A.J. (author), Til, H.P. (author), Spit, B.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A lifespan oral toxicity of vinyl chloride monomer (VCM) was carried out in Wistar rats, using five groups each of 60-80 males and 60-80 females. VCM was administered by incorporating polyvinyl chloride (PVC) powder with a high VCM content into the diet or by gastric intubation of a 10% VCM solution in soya-bean oil. The VCM doses (actual...
article 1981
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van Zwieten, M.J. (author), Solleveld, H.A. (author), Lindsey, J.R. (author), Instituut voor experimentele gerontologie TNO (author)
article 1980
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Maat, B. (author), Radiobiologisch Instituut TNO (author)
Warfarin administered to tumor-bearing mice reduces the number of spontaneous lung metastases. Both macrophage inhibitors silica and carrageenan abolish the warfarin-induced decrease in tumour metastasis, which strongly supports the concept that the antitumour effect of coumarin derivatives is mediated by stimulation of macrophages. The results...
article 1980
Searched for: subject:"Lung"
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