Searched for: subject:"Lung"
(1 - 5 of 5)
document
van der Does, A.M. (author), Amatngalim, G.D. (author), Keijser, B.J.F. (author), Hiemstra, P.S. (author), Villenave, R. (author)
The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of...
article 2018
document
Hiemstra, P.S. (author), Grootaers, G.G. (author), van der Does, A.M. (author), Krul, C.A.M. (author), Kooter, I.M. (author)
The epithelium that covers the conducting airways and alveoli is a primary target for inhaled toxic substances, and therefore a focus in inhalation toxicology. The increasing concern about the use of animal models has stimulated the development of in vitro cell culture models for analysis of the biological effects of inhaled toxicants. However,...
article 2018
document
LaCroix, G. (author), Koch, W. (author), Ritter, D. (author), Gutleb, A.C. (author), Larsen, S.T. (author), Loret, T. (author), Zanetti, F. (author), Constant, S. (author), Chortarea, S. (author), Rothen-Rutishauser, B. (author), Hiemstra, P.S. (author), Frejafan, E. (author), Hubert, P. (author), Gribaldo, L. (author), Kearns, P. (author), Aublant, J.M. (author), Diabaté, S. (author), Weiss, C. (author), de Groot, A. (author), Kooter, I.M. (author)
In vitro air–liquid interface (ALI) cell culture models can potentially be used to assess inhalation toxicology endpoints and are usually considered, in terms of relevancy, between classic (i.e., submerged) in vitro models and animal-based models. In some situations that need to be clearly defined, ALI methods may represent a complement or an...
article 2018
document
Khedoe, P.P.S.J. (author), Wong, M.C. (author), Wagenaar, G.T.M. (author), Plomp, J.J. (author), van Eck, M. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Hiemstra, P.S. (author), Berbée, J.F.P. (author)
Background: Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation, airways obstruction and emphysema, and is a risk factor for cardiovascular disease (CVD). However, the contribution of these individual COPD components to this increased risk is unknown. Therefore, the aim of this study was to determine the...
article 2013
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Bos, R. (author), van Leuven, C.J.M. (author), Stolk, J. (author), Hiemstra, P.S. (author), Ronday, H.K. (author), Nieuwenhuizen, W. (author), TNO Preventie en Gezondheid (author)
Upon stimulation, polymorphonuclear leucocytes (PMNs) release potent serine proteases, i.e. elastase, cathepsin C and proteinase 3, which contribute to the degradation of tissue and plasma components. Here, we describe the development of a plasma test to assess PMN-mediated fibrinogenolysis as a biochemical marker for actual PMN-derived...
article 1997
Searched for: subject:"Lung"
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