Searched for: subject:"Lung"
(1 - 20 of 135)

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van Eijk, M. (author), Hillaire, M.L.B. (author), Rimmelzwaan, G.F. (author), Rynkiewicz, M.J. (author), White, M.R. (author), Hartshorn, K.L. (author), Hessing, M. (author), Koolmees, P.A. (author), Tersteeg, M.H. (author), van Es, M.H. (author), Meijerhof, T. (author), Huckriede, A. (author), Haagsman, H.P. (author)
Innate immunity is critical in the early containment of influenza A virus (IAV) infection and surfactant protein D (SP-D) plays a crucial role in innate defense against IAV in the lungs. Multivalent lectin-mediated interactions of SP-D with IAVs result in viral aggregation, reduced epithelial infection, and enhanced IAV clearance by phagocytic...
article 2019
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Koivisto, A.J. (author), Kling, K.I. (author), Fonseca, A.S. (author), Brostrøm Bluhme, A. (author), Moreman, M. (author), Yu, M. (author), Costa, A.L. (author), Giovanni, B. (author), Ortelli, S. (author), Fransman, W. (author), Vogel, U. (author), Jensen, K.A. (author)
Nanoscale TiO2 (nTiO2) is manufactured in high volumes and is of potential concern in occupational health. Here, we measured workers exposure levels while ceramic honeycombs were dip coated with liquid photoactive nanoparticle suspension and dried with an air blade. The measured nTiO2 concentration levels were used to assess process specific...
article 2018
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van der Does, A.M. (author), Amatngalim, G.D. (author), Keijser, B.J.F. (author), Hiemstra, P.S. (author), Villenave, R. (author)
The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of...
article 2018
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Hiemstra, P.S. (author), Grootaers, G.G. (author), van der Does, A.M. (author), Krul, C.A.M. (author), Kooter, I.M. (author)
The epithelium that covers the conducting airways and alveoli is a primary target for inhaled toxic substances, and therefore a focus in inhalation toxicology. The increasing concern about the use of animal models has stimulated the development of in vitro cell culture models for analysis of the biological effects of inhaled toxicants. However,...
article 2018
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LaCroix, G. (author), Koch, W. (author), Ritter, D. (author), Gutleb, A.C. (author), Larsen, S.T. (author), Loret, T. (author), Zanetti, F. (author), Constant, S. (author), Chortarea, S. (author), Rothen-Rutishauser, B. (author), Hiemstra, P.S. (author), Frejafan, E. (author), Hubert, P. (author), Gribaldo, L. (author), Kearns, P. (author), Aublant, J.M. (author), Diabaté, S. (author), Weiss, C. (author), de Groot, A. (author), Kooter, I.M. (author)
In vitro air–liquid interface (ALI) cell culture models can potentially be used to assess inhalation toxicology endpoints and are usually considered, in terms of relevancy, between classic (i.e., submerged) in vitro models and animal-based models. In some situations that need to be clearly defined, ALI methods may represent a complement or an...
article 2018
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Todea, A.M. (author), Beckmann, S. (author), Kaminski, H. (author), Bard, D. (author), Bau, S. (author), Clavaguera, S. (author), Dahmann, D. (author), Dozol, H. (author), Dziurowitz, N. (author), Elihn, K. (author), Fierz, M. (author), Lidén, G. (author), Meyer-Plath, A. (author), Monz, C. (author), Neumann, V. (author), Pelzer, J. (author), Simonow, B.K. (author), Thali, P. (author), Tuinman, I. (author), van der Vleuten, A. (author), Vroomen, H. (author), Asbach, C. (author)
Personal monitors based on unipolar diffusion charging (miniDiSC/DiSCmini, NanoTracer, Partector) can be used to assess the individual exposure to nanoparticles in different environments. The charge acquired by the aerosol particles is nearly proportional to the particle diameter and, by coincidence, also nearly proportional to the alveolar lung...
article 2017
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Vlaanderen, J. (author), Pronk, A. (author), Rothman, N. (author), Hildesheim, A. (author), Silverman, D. (author), Hosgood, H.D. (author), Spaan, S. (author), Kuijpers, E. (author), Godderis, L. (author), Hoet, P. (author), Lan, Q. (author), Vermeulen, R. (author)
Background: Multi-wall carbon nanotubes (MWCNTs) are manufactured nanomaterials to which workers and the general population will be increasingly exposed in coming years. Little is known about potential human health effects of exposure to MWCNTs, but effects on the lung and the immune system have been reported in animal and mechanistic studies....
article 2017
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van der Voort, M.M. (author), Holm, K.B. (author), Kummer, P.O. (author), Teland, J.A. (author), van Doormaal, J.C.A.M. (author), Dijkers, H.P.A. (author)
An important blast injury mechanism is the rupture of the lungs and the gastrointestinal tract. In explosives safety studies and threat analysis the empirical model of Bowen is often used to quantify this mechanism. The original model predicts the lethality for a person in front of a reflecting surface caused by simple Friedlander blast waves....
article 2016
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Sivle, L.D. (author), Wensveen, P.J. (author), Kvadsheim, P.H. (author), Lam, F.P.A. (author), Visser, F. (author), Curé, C. (author), Harris, C.M. (author), Tyack, P.L. (author), Miller, P.J.O. (author)
Modern long-range naval sonars are a potential disturbance for marine mammals and can cause disruption of feeding in cetaceans. We examined the lunge-feeding behaviour of humpback whales Megaptera novaeangliae before, during and after controlled exposure experiments with naval sonar by use of acoustic and motion sensor archival tags attached to...
article 2016
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Heikkila, K. (author), Nyberg, S.T. (author), Madsen, I.E. (author), de Vroome, E. (author), Alfredsson, L. (author), Bjorner, J.B. (author), Borritz, M. (author), Burr, H. (author), Erbel, R. (author), Ferrie, J.E. (author), Fransson, E. (author), Geuskens, G.A. (author), Hooftman, W.E. (author), Houtman, I.L. (author), Jöckel, K.H. (author), Knutsson, A. (author), Koskenvuo, M. (author), Lunau, T. (author), Nielsen, M.L. (author), Nordin, M. (author), Oksanen, T. (author), Pejtersen, J.H. (author), Pentti, J. (author), Shipley, M.J. (author), Steptoe, A. (author), Suominen, S.B. (author), Theorell, T. (author), Vahtera, J. (author), Westerholm, P.J.M. (author), Westerlund, H. (author), Dragano, N. (author), Rugulies, R. (author), Kawachi, I. (author), Batty, G.D. (author), Singh-Manoux, A. (author), Virtanen, M. (author), Kivimäki, M. (author)
Background: Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear. Methods: This multi-cohort study examined the association between working hours and cancer risk in 116 462 men and women who were free of...
article 2016
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van der Valk, E.S. (author), Smans, L.C.C.J. (author), Hofstetter, H. (author), Stubbe, J.H. (author), de Vries, M. (author), Backx, F.J.G. (author), Hermus, A.R.M.M. (author), Zelissen, P.M.J. (author)
Background: Health-related quality of life in patients with Addison's disease has been assessed in various European countries, indicating a reduced quality of life. However, no studies have addressed the impact of Addison's disease on physical activity. Objective: The aim of this study was to investigate the quality of life in Dutch patients...
article 2016
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van der Heijden, R.A. (author), Morrison, M.C. (author), Sheedfar, F. (author), Mulder, P. (author), Schreurs, M. (author), Hommelberg, P.P.H. (author), Hofker, M.H. (author), Schalkwijk, C. (author), Kleemann, R. (author), Tietge, U.J.F. (author), Koonen, D.P.Y. (author), Heeringa, P. (author)
Background. Naturally occurring substances from the flavanol and anthocyanin family of polyphenols have been proposed to exert beneficial effects in the course of obesity. We hypothesized that their effects on attenuating obesity-induced dyslipidemia as well as the associated inflammatory sequelae especially have health-promoting potential....
article 2016
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Mutlu, E. (author), Nash, D.G. (author), King, C. (author), Krantz, T.Q. (author), Preston, W.T. (author), Kooter, I.M. (author), Higuchi, M. (author), DeMarini, D. (author), Linak, W.P. (author), Ian Gilmour, M. (author)
Biodiesel made from the transesterification of plant- and animal-derived oils is an important alternative fuel source for diesel engines. Although numerous studies have reported health effects associated with petroleum diesel emissions, information on biodiesel emissions are more limited. To this end, a program at the U.S. EPA assessed health...
article 2015
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Tan, E. (author), Boessen, R. (author), Fishwick, D. (author), Klein Entink, R. (author), Meijster, T. (author), Pronk, A. (author), van Duuren-Stuurman, B. (author), Warren, N. (author)
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that is thought to affect over one million people in Great Britain. The main factor contributing to the development of COPD is tobacco smoke. This paper presents a microsimulation model for the development of COPD, incorporating population dynamics and trends in smoking. The...
article 2015
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Groothuis-Oudshoorn, C.G.M. (author), Chorus, A.M.J. (author), Verrips, G.H.W. (author), Detmar, S.B. (author)
BACKGROUND: The London Handicap Scale (LHS) was found to be a valid and reliable scale for measuring participation restrictions in adults. OBJECTIVE: This paper describes the development and assesses the construct-related validity of a Dutch version of the London Handicap Scale (DLHS). METHODS: The DLHS was tested in 798 adults (mean age: 50.7...
article 2015
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Raiten, D.J. (author), Sakr Ashour, F.A. (author), Ross, A.C. (author), Meydani, S.N. (author), Dawson, H.D. (author), Stephensen, C.B. (author), Brabin, B.J. (author), Suchdev, P.S. (author), van Ommen, B. (author), Ahluwalia, N. (author), Ahmed, T. (author), Allen, L. (author), Beck, M. (author), Blanchard, H. (author), Brindle, E. (author), Brown, K. (author), Calder, P. (author), Checkley, W. (author), Claycombe, K. (author), Coles, C. (author), Esamai, F. (author), Friis, H. (author), Gardner, E. (author), Grinspoon, S. (author), Guerrant, R. (author), Hellerstein, M. (author), Hunt, J. (author), King, J. (author), Klasing, K. (author), Kramer, B. (author), Koski, K. (author), Northrop-Clewes, C. (author), Pfeiffer, C. (author), Prentice, A. (author), Ramirez-Zea, M. (author), van Rheenan, P. (author), Rink, L. (author), Srinivasa, S. (author), Benn, C.S. (author), Stephensen, C. (author), Suchdev, P. (author), Sullivan, K. (author), Thurnham, D. (author), Varadhan, R. (author), Van Der Ven, A. (author), Walston, J. (author), Xia, J. (author)
An increasing recognition has emerged of the complexities of the global health agenda-specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and...
article 2015
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Eeftens, M. (author), Hoek, G. (author), Gruzieva, O. (author), Mölter, A. (author), Agius, R. (author), Beelen, R. (author), Brunekreef, B. (author), Custovic, A. (author), Cyrys, J. (author), Fuertes, E. (author), Heinrich, J. (author), Hoffmann, B. (author), De Hoogh, K. (author), Jedynska, A. (author), Keuken, M. (author), Klümper, C. (author), Kooter, I. (author), Krämer, U. (author), Korek, M. (author), Koppelman, G.H. (author), Kuhlbusch, T.A.J. (author), Simpson, A. (author), Smit, H.A. (author), Tsai, M.Y. (author), Wang, M. (author), Wolf, K. (author), Pershagen, G. (author), Gehring, U. (author)
BACKGROUND: Negative effects of long-term exposure to particulate matter (PM) on lung function have been shown repeatedly. Spatial differences in the composition and toxicity of PM may explain differences in observed effect sizes between studies. METHODS: We conducted a multicenter study in 5 European birth cohorts - BAMSE (Sweden), GINIplus and...
article 2014
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Blaauboer, M.E. (author), Boeijen, F.R. (author), Emson, C.L. (author), Turner, S.M. (author), Zandieh-Doulabi, B. (author), Hanemaaijer, R. (author), Smit, T.H. (author), Stoop, R. (author), Everts, V. (author)
Lung fibrosis is characterized by excessive deposition of extracellular matrix. This not only affects tissue architecture and function, but it also influences fibroblast behavior and thus disease progression. Here we describe the expression of elastin, type V collagen and tenascin C during the development of bleomycin-induced lung fibrosis. We...
article 2014
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Koeman, T. (author), van den Brandt, P.A. (author), Slottje, P. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), Kromhout, H. (author), Vermeulen, R. (author)
Purpose: To investigate the association between exposure to occupational extremely low-frequency magnetic fields (ELF-MF) and the risk of a priori selected cancer outcomes within the prospective Netherlands Cohort Study. Methods: 120,852 men and women aged 55-69 years at time of enrollment in 1986 were followed up (17.3 years) for incident lung,...
article 2014
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Blaauboer, M.E. (author), Emson, C.L. (author), Verschuren, L. (author), van Erk, M. (author), Turner, S.M. (author), Everts, V. (author), Hanemaaijer, R. (author), Stoop, R. (author)
Collagen deposition is a key process during idiopathic pulmonary fibrosis; however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen content, since standard collagen analyses do not...
article 2013
Searched for: subject:"Lung"
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