Searched for: subject%3A%22Loperamide%22
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Groten, J.P. (author), Schoen, E.D. (author), van Bladeren, P.J. (author), Kuper, C.F. (author), van Zorge, J.A. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The present study was intended (1) to find out whether simultaneous administration of nine chemicals at a concentration equal to the 'no-observed-adverse-effect level' (NOAEL) for each of them would result in a NOAEL for the combination and (2) to test the usefulness of fractionated factorial models to detect possible interactions between...
article 1997
Groten, J.P. (author), Schoen, E.D. (author), Feron, V.J. (author), TNO Voeding (author)
The use of factorial designs, in which n chemicals are studied at x(n) dose levels (x treatment groups), has been put forward as one of the valuable statistical approaches for hazard assessment of chemical mixtures. Very recently a '25 study' was presented to describe interactions between the carcinogenic activity of five polycyclic aromatic...
article 1996
Centraal Instituut voor Voedingsonderzoek TNO (author), Jonker, D. (author), Woutersen, R.A. (author), van Bladeren, P.J. (author), Til, H.P. (author), Feron, V.J. (author)
In a 4-wk oral toxicity study, 4-wk-old male and female Wistar rats were exposed to a combination of arbitrarily chosen chemicals comprising sodium metabisulphite, Mirex, Loperamide, metaldehyde, di-n-octyltin dichloride, stannous chloride, lysinoalanine and potassium nitrite. The dose levels used were based on the 'no-observed-adverse-effect...
article 1990