Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis

Objective: To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix metalloproteinase (MMP) activity in α2 macroglobulin (α2M)/MMP complexes and the progression of joint destruction in patients with recent onset rheumatoid arthritis (RA). Methods: 109 patients with RA of recent onset were entered into this longitudinal...

Tandheelkundige verzorging jeugdige ziekenfondsverzekerden. 2. Prevalentie en behandeling van orthodontische afwijkingen tussen 1987 en 1999 [Oral health care in young people insured by a health insurance fund. 2. Prevalence and treatment of malocclusions in the Netherlands between 1987-1999]

In this paper data are presented about malposition of teeth in 5-, 11-, 17- and 23-year-olds in the time period between 1987-1999. Furthermore, results are shown of a longitudinal study in youngsters 11-17-years of age of whom some were and others were not treated orthodontically. Between 1987 and 1999, the percentage of youngsters who received...

Eye movements to yaw, pitch, and roll about vertical and horizontal axes: adaptation, and motion sickness

Background: In the search for parameters to predict motion sickness that can be measured in the laboratory, we performed a longitudinal investigation in aviators. Since the vestibular system is involved in the generation of motion sickness as well as eye movements, vestibulo-ocular reflex (VOR) parameters seemed relevant. We investigated three...

High quantitative job demands and low coworker support as risk factors for neck pain: Results of a prospective cohort study

Study Design. A 3-year prospective cohort study among 1334 workers was conducted. Objective. To determine whether the work-related psychosocial factors of quantitative job demands, conflicting job demands, skill discretion, decision authority, supervisor support, coworker support, and job security are risk factors for neck pain. Summary of...

Are neck flexion, neck rotation, and sitting at work risk factors for neck pain? Results of a prospective cohort study

Objective: To study the relation between neck pain and work related neck flexion, neck rotation, and sitting. Methods: A prospective cohort study was performed with a follow up of 3 years among 1334 workers from 34 companies. Work related physical load was assessed by analysing objectively measured exposure data (video recordings) of neck...

The value of salivary bacterial counts as a supplement to past caries experience as caries predictor in children

This study aimed to determine whether salivary mutans streptococci and lactobacilli counts could add any value to a combination of caries experience variables that was recently presented for the prediction of caries. Sixty-nine children at the age of 7.5 yr participated in this longitudinal study. Microbiological data were obtained at the ages...

Netherlands twin family study of anxious depression (NETSAD)

In a longitudinal study of Dutch adolescent and young adult twins, their parents and their siblings, questionnaire data were collected on depression, anxiety and correlated personality traits, such as neuroticism. Data were collected by mailed surveys in 1991, 1993, 1995 and 1997. A total of 13 717 individuals from 3344 families were included in...

Zygosity diagnosis in young twins by parental report

This study reports on zygosity determination in twins of childhood age. Parents responded to questionnaire items dealing with twin similarity in physical characteristics anti frequency of mistaking one twin for another by parents, relatives and strangers. The accuracy of zygosity diagnosis was evaluated across twins aged 6, 8, and 10 and across...

Decreased interleukin-10 and increased interleukin- 12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis

It has been shown that proinflammatory and antiinflammatory cytokines correlate with disease activity in multiple sclerosis (MS). To establish whether such correlations depend on the disease stage, we assessed in a longitudinal fashion the expression of interleukin (IL)-12 (p40 and p35), tumor necrosis factor- 1/4 , interferon-γ, and IL-10 mRNA...

Association between apolipoprotein E ε4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia

Objective: To determine whether the apolipoprotein E ε4 allele (apoE ε4) is associated with cognitive decline in individuals with and without dementia, we conducted a 4-year longitudinal study of subjects with a range of cognitive function Setting: At baseline, respondents (n = 511) were randomly selected according to age and Mini-Mental State...

Perinatal exposure to polychlorinated biphenyls and dioxins and its effect on neonatal neurological development

Polychlorinated biphenyls (PCBs) and dioxins (polychlorinated dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs)) are widespread environmental contaminants which are neurotoxic in animals. Perinatal exposure to PCBs, PCDDs, and PCDFs occurs prenatally via the placenta and postnatally via breast milk. To investigate whether such an exposure...

De betekenis van consulieachtige verschijnselen in de eerste twee levensjaren [mportance of convulsion-like signs during the first two years of life]

Objective. Assessment of the prevalence of convulsion-like symptoms in 1854 children of Dutch-speaking mothers of a population-based birth cohort. Method. At each child health clinic (CHC) visit mothers were asked whether they had noted any of the following signs: loss of consciousness, involuntary movements, eye rotation movements and apnoea,...

The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: A longitudinal study

The influence of aging on the metabolism of antipyrine (AP) and hexobarbital enantiomers (R-HB and S-HB) with and without phenobarbital (PB) induction was investigated in a longitudinal study in rats aged 6, 12, 24 and 30 months. The metabolic clearances of AP (Cl(m AP)), R-HB (Cl(m R-HB)) and S-HB (Cl(m S-HB)) were used as indicators for P450...

Gezondheidsproblemen na ernstige vroeggeboorte: 9 jaar naonderzoek [Health problems after very premature birth; nine years follow-up]

Sexually transmitted diseases reported by STD services in the Netherlands, 1984-1990

Objective - To present general trends in sexually transmitted disease (STD) in the Netherlands during the period 1984-1990 and to describe characteristics of the patients in order to get insight into possible factors underlying these trends. Methods - Since 1984 patients diagnosed with STD visiting STD clinics and local public health services in...

Fluoride in drinking water and caries progression in a Tanzanian child population