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Langendijk, E.H.A. (author), Kistler, D.J. (author), Wightman, F.L. (author), TNO Technische Menskunde (author)Localizing a target sound can be a challenge when one or more distracter sounds are present at the same time. This study measured the effect of distracter position on target localization for one distracter (17 positions) and two distracters (21 combinations of 17 positions). Listeners were instructed to point to the apparent position of a train...article 2001
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van Och, F.M.M. (author), Vandebriel, R.J. (author), Prinsen, M.K. (author), de Jong, W.H. (author), Slob, W. (author), van Loveren, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The guinea pig maximization test (GPMT) has been used as a method for the prediction of skin sensitizing potential for over 30 years. Besides hazard identification, risk assessment of sensitizing chemicals requires the assessment of potency. For the determination of potency based on lowest effective dose levels, dose-response studies are...article 2001
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Reichl, F.X. (author), Walther, U.I. (author), Durner, J. (author), Kehe, K. (author), Hickel, R. (author), Kunzelmann, K.H. (author), Spahl, W. (author), Hume, W.R. (author), Benschop, H.P. (author), Forth, W. (author)Objective: The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA), as well as mercuric chloride (HgCl2) and methylmercury chloride (MeHgCl) was investigated on the release of lactatedehydrogenase (LDH) from alveolar epithelial lung cell lines in vitro. Methods: The confluent cell...article 2001
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Energieonderzoek Centrum Nederland (author), Ligthart, F.A.T.M. (author), Lafleur, M.C.C. (author), Sijpheer, N.C. (author)-report 2001
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van Bladeren, P.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In general, glutathione conjugation is regarded as a detoxication reaction. However, depending on the properties of the substrate, bioactivation is also possible. Four types of activation reaction have been recognized: direct-acting compounds, conjugates that are activated through cysteine conjugate beta-lyase, conjugates that are activated...article 2000
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TNO Wegtransportmiddelen (author), Wang, W.M. (author), Pozivilova, A. (author), Sluys, L.J. (author)An objective stress update algorithm has been proposed for the framework of additive and multiplicative (visco)plasticity. The procedure for the two approaches is implemented such that extension from a small strain finite element code to the finite strain range is straigthforward. Objectivity can be retained for any choice of the intermediate...conference paper 2000
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Energieonderzoek Centrum Nederland (author), van Dril, A.W.N. (author), Burger, H. (author)-report 2000
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Energieonderzoek Centrum Nederland (author), Koopmans, B.T. (author)-report 2000
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Drullman, R. (author), Bronkhorst, A.W. (author)In a 3D auditory display sounds are presented over headphones in a way that they seem to originate from virtual sources in a space around the listener. This paper describes a study on the possible merits of such a display for bandlimited speech with respect to intelligibility and talker recognition against a background of competing voices....article 2000
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van Mechelen, J.R. (author), Schuurink, R.C. (author), Smits, M. (author), Graner, A. (author), Douma, A.C. (author), Sedee, N.J.A. (author), Schmitt, N.F. (author), Valk, B.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Two full-length lipoxygenase cDNA sequences (LoxB and LoxC) from barley (Hordeum distichum cv. L. Triumph) are described. The cDNAs share high homology with the barley LoxA cDNA. Southern blotting experiments indicate single copy numbers of the three lipoxygenase genes. RFLP mapping revealed the presence of single lipoxygenase loci. LoxA and...article 1999
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Cramer, J.M. (author), Reijenga, F.A. (author), TNO Strategie, Technologie en Beleid (author)This article discusses the role of innovators in the introduction of 'preventive environmental' policy in local government in the Netherlands. With the help of the configuration theory of Mintzberg and the innovation theory of Rogers a description is given of making this new prevention policy within the governmental organization. This process of...article 1999
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Wijnberg, M.J. (author), Slomp, J. (author), Verheijen, J.H. (author), Gaubius instituut TNO (author)In this study we examined the localization of the plasminogen activation system and the matrix metalloproteinases in normal human arteries, arteries with diffuse intimal thickenings and atherosclerotic arteries. We found that MMP-1, MMP-2, MMP-3, TIMP-1 and TIMP-2 did not stain differently in normal arteries, arteries with intimal thickening and...article 1999
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Snellen, M. (author), Simons, D.G. (author), TNO Fysisch en Elektronisch Laboratorium (author)In the field of underwater acoustics the signal processing technique " Matched Fieldconference paper 1998
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Duizer, E. (author), van der Wulp, C. (author), Versantvoort, C.H.M. (author), Groten, J.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Palmitoyl carnitine chloride (PCC) has been shown to be an effective enhancer of intestinal transport of hydrophilic molecules. The exact mechanism by which the epithelial barrier function is decreased is not clear. In an attempt to elucidate the mechanism of action of PCC, we studied the relationship among absorption enhancement, cell viability...article 1998
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Raussens, V. (author), de Jongh, H. (author), Pézolet, M. (author), Ruysschaert, J.-M. (author), Goormaghtigh, E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Models of P-type ATPase predict that membrane-embedded fragments represent about 20% of the protein and adopt an all-α-helical structure. While this prediction was confirmed for the Ca2+ -ATPase [Corbalan-Garcia, S., Teruel, J., Villalain, J. and Gomez-Fernandez, J. (1994) Biochemistry 33, 8247-8254], it is at odds with recent experimental...article 1998
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Gresnigt, A.M. (author), van Foeken, R.J. (author), Chen, S.L. (author)Rupture of the pipe wall and inadmissible deformations are the two basic failure modes that can he distinguished in pipelines. Rupture can be the result of (a) the fact that the experienced strains exceed the strain capacity of the pipe wall, including less ductile zones in and near the weids and (b) high cycle and/or low cycle fatigue loading....conference paper 1996
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Twisk, J. (author), Hoekman, M.F.M. (author), Mager, W.H. (author), Moorman, A.F.M. (author), de Boer, P.A.J. (author), Scheja, L. (author), Princen, H.M.G. (author), Gebhardt, R. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)We investigated the lobular localization and molecular level of expression of cholesterol 7α-hydroxylase and sterol 27-hydroxylase, two key enzymes in bile acid synthesis, in isolated periportal and pericentral hepatocytes and by in situ hybridization of rat liver. Enzyme activity, mRNA, and gene transcription of cholesterol 7α-hydroxylase were...article 1995
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Otter, M. (author), Kuiper, J. (author), Rijken, D. (author), van Zonneveld, A.-J. (author), TNO Preventie en Gezondheid (author)To characterize the primary structure of rat Vn, a cDNA library constructed from freshly isolated rat hepatocytes, was screened with a human Vn cDNA probe. Comparison of the sequence of the obtained rat cDNA clone with the sequences of human, mouse and rabbit Vn cDNA's showed predominantly consensus in the somatomedin B domain, the RGD-sequence...article 1995
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- Aoki, S. (author), Houtgast, T. (author), TNO Human Factors (author) article 1994
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van den Berg, K.J. (author), Gramsbergen, J.B.P. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: calcium, 7440-70-2; kainic acid, 487-79-6; Biological Markers; Calcium, 7440-70-2; Glial Fibrillary Acidic Protein; Kainic Acid, 487-79-6; Neurotoxinsarticle 1993