Searched for: subject:"Lipoproteins%2C%5C+HDL"
(1 - 20 of 23)

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Bijland, S. (author), Pieterman, E.J. (author), Maas, A.C.E. (author), van der Hoorn, J.W.A. (author), van Erk, M.J. (author), van Klinken, J.B. (author), Havekes, L.M. (author), van Dijk, K.W. (author), Princen, H.M.G. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)
The peroxisome proliferator-activated receptor alpha (PPARα) activator fenofibrate efficiently decreases plasma triglycerides (TG), which is generally attributed to enhanced very low density lipoprotein (VLDL)-TG clearance and decreased VLDL-TG production. However, because data on the effect of fenofibrate on VLDL production are controversial,...
article 2010
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Westerterp, M. (author), van der Hoogt, C.C. (author), de Haan, W. (author), Offerman, E.H. (author), Dallinga-Thie, G.M. (author), Jukema, J.W. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), TNO Kwaliteit van Leven (author)
OBJECTIVE - The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate. Therefore, we evaluated the effect of human CETP expression on atherosclerosis in APOE*3-Leiden (E3L) mice with a humanized lipoprotein profile. METHODS AND RESULTS - E3L mice were crossbred with human CETP...
article 2006
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Rensen, P.C.N. (author), Havekes, L.M. (author), TNO Kwaliteit van Leven (author)
Chemicals / CAS: 2 methylpropanethioic acid s [2 [1 (2 ethylbutyl)cyclohexylcarboxamido]phenyl] ester, 211513-37-0; atorvastatin, 134523-00-5, 134523-03-8; nicotinic acid, 54-86-4, 59-67-6; torcetrapib, 262352-17-0; Carrier Proteins; CETP protein, human; Cholesterol Ester Transfer Proteins; Cholesterol Esters; Cholesterol, HDL; Glycoproteins;...
article 2006
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Kypreos, K.E. (author), van Dijk, K.W. (author), Havekes, L.M. (author), Zannis, V.I. (author), TNO Kwaliteit van Leven (author)
To identify the residues in the carboxyl-terminal region 260-299 of human apolipoprotein E (apoE) that contribute to hypertriglyceridemia, two sets of conserved, hydrophobic amino acids between residues 261 and 283 were mutated to alanines, and recombinant adenoviruses expressing these apoE mutants were generated. Adenovirus-mediated gene...
article 2005
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Hendriks, H.F. (author), van Tol, A. (author), TNO Kwaliteit van Leven (author)
Alcohol consumption affects overall mortality. Light to moderate alcohol consumption reduces the risk of coronary heart disease; epidemiological, physiological and genetic data show a causal relationship. Light to moderate drinking is also associated with a reduced risk of other vascular diseases and probably of type 2 diabetes. Mortality and...
bookPart 2005
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TNO Kwaliteit van Leven (author), Gautier, T. (author), Masson, D. (author), Jong, M.C. (author), Pais De Barros, J.P. (author), Duverneuil, L. (author), Le Guern, N. (author), Deckert, V. (author), Dumont, L. (author), Bataille, A. (author), Zak, Z. (author), Jiang, X.C. (author), Havekes, L.M. (author), Lagrost, L. (author)
ApoCI (apolipoprotein CI) is a potent inhibitor of plasma CETP [CE (cholesteryl ester) transfer protein]. The relevance of apoCI overexpression as a method for CETP blockade in vivo was addressed in the present study in CETPTg/apoCITg mice (mice expressing both human CETP and apoCI). Despite a significant reduction in specific CETP activity in...
article 2005
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Sierksma, A. (author), Sarkola, T. (author), Eriksson, C.J.P. (author), van der Gaag, M.S. (author), Grobbee, D.E. (author), Hendriks, H.F.J. (author), TNO Voeding (author)
Background: Moderate alcohol consumption is inversely associated with cardiovascular diseases. Changes in hormone levels might in part help explain the positive health effect. This study was performed to examine the effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate (DHEAS), testosterone, and estradiol levels....
article 2004
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Beulens, J.W.J. (author), Sierksma, A. (author), van Tol, A. (author), Fournier, N. (author), van Gent, T. (author), Paul, J.L. (author), Hendriks, H.F.J. (author), TNO Voeding (author)
Moderate alcohol consumption increases HDL cholesterol, which is involved in reverse cholesterol transport (RCT). The aim of this study was to investigate the effect of moderate alcohol consumption on cholesterol efflux, using J774 mouse macrophages and Fu5AH cells, and on other parameters in the RCT pathway. Twenty-three healthy men (45-65...
article 2004
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Out, R. (author), Kruijt, J.K. (author), Rensen, P.C.N. (author), Hildebrand, R.B. (author), de Vos, P. (author), van Eck, M. (author), van Berkel, T.J.C. (author), TNO Preventie en Gezondheid (author)
The function of scavenger receptor class B type I (SR-BI) in mediating the selective uptake of high density lipoprotein (HDL) cholesterol esters is well established. However, the potential role of SR-BI in chylomicron and chylomicron remnant metabolism is largely unknown. In the present investigation, we report that the cell association of 160...
article 2004
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van Tol, A. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Light to moderate alcohol consumption is associated with a reduced risk of coronary heart disease, as well as ischaemic stroke and possibly type 2 diabetes. Epidemiological and physiological data are in favour of a causal relationship. Proposed protective mechanisms include the stimulation of HDL-mediated processes such as reverse cholesterol...
article 2001
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van der Gaag, M.S. (author), van Tol, A. (author), Vermunt, S.H.F. (author), Scheek, L.M. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Alcohol consumption is associated with increased HDL cholesterol levels, which may indicate stimulated reverse cholesterol transport. The mechanism is, however, not known. The aim of this study was to evaluate the effects of alcohol consumption on the first two steps of the reverse cholesterol pathway: cellular cholesterol efflux and plasma...
article 2001
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te Loo, D.M.W.M. (author), Monnens, L.A.H. (author), van der Velden, T.J.A.M. (author), Vermeer, M.A. (author), Preyers, F. (author), Demacker, P.N.M. (author), van den Heuvel, L.P.W.J. (author), van Hinsbergh, V.W.M. (author), Gaubius instituut TNO (author)
The hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children. The role of a verocytotoxin (VT)-producing Escherichia coli has been strongly implicated in the epidemic form of HUS. Although direct toxicity of VT on glomerular endothelial cells has been demonstrated, it remained still unclear how the VT is...
article 2000
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van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), Couet, C. (author), Aro, A. (author), Kafatos, A. (author), Steingrimsdottir, L. (author), Amorim Cruz, J.A. (author), Moreiras, O. (author), Becker, W. (author), van Amelsvoort, J.M.M. (author), Vidal-Jessel, S. (author), Salminen, I. (author), Moschandreas, J. (author), Sigfússon, N. (author), Martins, I. (author), Carbajal, A. (author), Ytterfors, A. (author), van Poppel, G. (author)
Background: High intakes of trans fatty acids (TFA) have been found to exert an undersirable effect on serum lipid profiles, and thus may increase the risk for cardiovascular disease. Objective: Investigation of the association between TFA intake and serum lipids. Design: Cross-sectional study in eight European countries (Finland, France, Greece...
article 2000
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van der Gaag, M.S. (author), van Tol, A. (author), Scheek, L.M. (author), James, R.W. (author), Urgert, R. (author), Schaafsma, G. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Moderate alcohol consumption is associated with a reduced risk of coronary heart disease. Part of this inverse association may be explained by its effects on HDL. Paraoxonase, an HDL-associated enzyme, has been suggested to protect against LDL oxidation. We examined the effects of moderate consumption of red wine, beer and spirits in comparison...
article 1999
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van Tol, A. (author), van der Gaag, M.S. (author), Scheek, L.M. (author), van Gent, T. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
We measured the effects of consumption of moderate amounts of beer, wine or spirits with evening dinner on plasma LDL and HDL levels as well as composition in 11 healthy middle-aged men. Forty grams of alcohol were consumed daily with dinner for a period of 3 weeks. Mineral water was used as a negative control. Dinner was served at 6 pm and...
article 1998
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Ehnholm, S. (author), van Dijk, K.W. (author), van Hof, B. (author), van Zee, A.D. (author), Olkkonen, V.M. (author), Jauhiainen, M. (author), Hofker, M. (author), Havekes, L. (author), Ehnholm, C. (author), Gaubius Instituut TNO (author)
To study the function of plasma phospholipid transfer protein (PLTP) in vivo, a liver directed adenoviral gene transfer system was used to overexpress human PLTP in mice. For the experiments, two strains of mice, wild type (C57/B1) and mice transgenic for the human apoA-I gene (HuApoA- ITg), were utilized. Five days after injection of the...
article 1998
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van Vlijmen, B.J.M. (author), Mensink, R.P. (author), van 't Hof, H.B. (author), Offermans, R.F.G. (author), Hofker, M.H. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
Studying the effects of dietary fish oil on VLDL metabolism in humans is subject to both large intra- and interindividual variability. In the present study we therefore used hyperlipidentic apolipoprotein (APO) E*3-Leiden mice, which have impaired chylomicron and very low density lipoprotein (VDL) remnant metabolism, to study the effects of...
article 1998
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van Ree, J.H. (author), Hofker, M.H. (author), van den Broek, J.A.A. (author), van Deursen, J.M.A. (author), van der Boom, H. (author), Frants, R.R. (author), Wieringa, B. (author), Havekes, L.M. (author), Gaubius Instituut TNO (author)
The function of apolipoprotein (apo) C1 in vivo is not well understood. From in vitro studies it has been reported that an excess of apoC1 relative to apoE inhibits receptor-mediated uptake of remnant lipoproteins. In order to gain a better understanding of the role of apoC1 in lipoprotein metabolism in vivo, we have generated apoC1-deficient...
article 1995
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Pikaar, N.A. (author), Wedel, M. (author), van der Beek, E.J. (author), van Dokkum, W. (author), Kempen, H.J.M. (author), Kluft, C. (author), Ockhuizen, T. (author), Hermus, R.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
To investigate the effect of moderate alcohol consumption on blood constituents related to cardiovascular disease, 12 male volunteers consumed (instead of their usual alcoholic drinks) four different standardized amounts of red wine in addition to their habitual diet. Each dose was given to the subjects during a period of 5 weeks in a randomized...
article 1987
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Kempen, H.J. (author), Kuipers, F. (author), van Berkel, T.J.C. (author), Vonk, R.J. (author), Gaubius instituut TNO (author)
As shown by us previously (van Berkel et al. 1985. J. Biol. Chem. 260: 2694-2699 and van Berkel et al. 1985. J. Biol. Chem. 260: 12203-12207) the clearance of both low density lipoproteins (LDL) and high density lipoproteins (HDL) from the blood can be greatly enhanced by pretreatment of these lipoproteins with a tris-galactosylated cholesterol...
article 1987
Searched for: subject:"Lipoproteins%2C%5C+HDL"
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