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Salic, K. (author), Gart, E. (author), Verschuren, L. (author), van Duyvenvoorde, W. (author), Wong, K.E. (author), Keijer, J. (author), Bobeldijk-Pastorova, I. (author), Wielinga, P.Y. (author), Kleemann, R. (author)Obesity characterized by adiposity and ectopic fat accumulation is associated with the development of non-alcoholic fatty liver disease (NAFLD). Treatments that stimulate lipid utilization may prevent the development of obesity and comorbidities. This study evaluated the potential anti-obesogenic hepatoprotective effects of combined treatment...article 2019
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Tsikas, D. (author), Pham, V.V. (author), Suchy, M.T. (author), van de Ree, M.A. (author), Huisman, M.V. (author), Frölich, J.C. (author), Princen, H.M.G. (author)The present study describes the effects of atorvastatin on whole body synthesis of nitric oxide (NO), prostacyclin (PGI2), and thromboxane A2 (TxA2), on oxidative stress and nitrite/nitrate-related renal carbonic anhydrase (CA) activity in patients with type 2 diabetes mellitus (T2DM). A double-blind, randomized, placebo-controlled parallel...article 2015
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van Tits, L.J.H. (author), van Heerde, W.L. (author), van der Vleuten, G.M. (author), de Graaf, J. (author), Grobbee, D.E. (author), van de Vijver, L.P.L. (author), Stalenhoef, A.F. (author), Princen, H.M. (author), TNO Kwaliteit van Leven (author)Exogenous radiolabeled annexin A5 is taken up by atherosclerotic tissue. We measured endogenous plasma annexin A5 and circulating oxidized low-density lipoprotein (oxLDL), a biochemical marker of atherosclerosis, in men with either severe angiographically determined coronary stenosis (n = 90) or no or only minor stenosis (n = 96). Men without...article 2007
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Oudshoorn, J.H. (author), Lecluse, A.L.Y. (author), van den Berg, R. (author), Vaes, W.H.J. (author), van der Laag, J. (author), Houwen, R.H.J. (author), TNO Kwaliteit van Leven (author)OBJECTIVES: Coenzyme Q10 (CoQ10) is an effective lipophilic antioxidant and protects against lipid peroxidation by scavenging radicals. Patients with cystic fibrosis generally have fat malabsorption; thus, we hypothesized that overall plasma CoQ10 concentration in pediatric patients with cystic fibrosis might be diminished. Because these...article 2006
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van Dijk, B.A.C. (author), Schouten, L.J. (author), Kiemeney, L.A.L.M. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding (author)Data from the Netherlands Cohort Study on Diet and Cancer were used to investigate the association between anthropometry, energy intake, and physical activity and risk of renal cell carcinoma (RCC). The Netherlands Cohort Study on Diet and Cancer consists of 120,852 men and women aged 55-69 years who completed a self-administered questionnaire...article 2004
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Dommels, Y.E.M. (author), Haring, M.M.G. (author), Keestra, N.G.M. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author)This study was conducted to investigate the role of the enzyme cyclooxygenase (COX) and its prostaglandin product PGE2 in n-6 and n-3 polyunsaturated fatty acid (PUFA)-mediated effects on cellular proliferation of two human colorectal carcinoma cell lines. The long chain PUFAs eicosapentaenoic acid (EPA; 20:5n-3) and arachidonic acid (AA; 20:4n...article 2003
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Broekmans, W.M.R. (author), Klöpping-Ketelaars, I.A.A. (author), Weststrate, J.A. (author), Tijburg, L.B.M. (author), van Poppel, G. (author), Vink, A.A. (author), Berendschot, T.T.J.M. (author), Bots, M.L. (author), Castenmiller, W.A.M. (author), Kardinaal, A.F.M. (author)Excessive consumption of energy and fat increases the risk for obesity. Snacks containing sucrose polyesters (SPE) as a dietary fat replacer are on the market in the United States. SPE products have been shown to lower concentrations of serum carotenoids in short-term studies. Experimental studies on the longer-term effects on health of...article 2003
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Dommels, Y.E.M. (author), Heemskerk, S. (author), van den Berg, H. (author), Alink, G.M. (author), van Bladeren, P.J. (author), van Ommen, B. (author)Modulating effects of high fat fish oil (HFFO) and high fat corn oil (HFCO) diets on azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) were studied in male F344 rats following 8 weeks of dietary treatment. The incidence of AOM-induced ACF was significantly lower in the proximal colon of rats fed the HFFO diets compared with rats fed...article 2003
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Rhodes, L.E. (author), Shahbakhti, H. (author), Azurdia, R.M. (author), Moison, R.M.W. (author), Steenwinkel, M.J.S.T. (author), Homburg, M.I. (author), Dean, M.P. (author), McArdle, F. (author), Beijersbergen van Henegouwen, G.M.J. (author), Epe, B. (author), Vink, A.A. (author)Dietary omega-3 polyunsaturated fatty acids (ω-3 PUFAs) protect against photocarcinogenesis in animals, but prospective human studies are scarce. The mechanism(s) underlying the photoprotection are uncertain, although ω-3 PUFAs may influence oxidative stress. We examined the effect of supplementation on a range of indicators of ultraviolet...article 2003
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van den Berg, R. (author), Haenen, G.R.M.M. (author), van den Berg, H. (author), van der Vijgh, W. (author), Bast, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The antioxidant capacity of a series of structurally related flavonoids is quantified by the amount of ABTS [2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate)] radical anions (ABTS(.)-) that is able to react with the flavonoid and expressed as the Trolox equivalent antioxidant capacity (TEAC). To evaluate the predictive value of the TEAC, the...article 2000
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Anderson, D. (author), Phillips, B.J. (author), Yu, T-W. (author), Edwards, A.J. (author), Ayesh, R. (author), Butterworth, K.R. (author)Twenty-four men and 24 women, all nonsmoking, and maintaining normal dietary habits were assigned to 3 groups of 16. Each group comprising 4 males with "low" cholesterol levels (<6 mmol/L) matched for age and build with 4 males with "high" cholesterol levels (>6 mmol/L) and 8 similarly matched females. A three-treatment, three-treatment period,...article 2000
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van de Vijver, L.P.L. (author), Kardinaal, A.F.M. (author), van Duyvenvoorde, W. (author), Kruijssen, D.A.C.M. (author), Grobbee, D.E. (author), van Poppel, G. (author), Princen, H.M.G. (author), TNO Preventie en Gezondheid (author)Evidence has accumulated for oxidative modification of low-density lipoproteins (LDL) to play an important role in the atherogenic process. Therefore, we investigated the relation between susceptibility of LDL to oxidation and risk of peripheral atherosclerosis among 249 men between 45 and 80 years of age. The ankle-arm index was calculated for...article 1999
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Klipstein-Grobusch, K. (author), Grobbee, D.E. (author), den Breeijen, J.H. (author), Boeing, H. (author), Hofman, A. (author), Witteman, J.C.M. (author)Free iron has been implicated in lipid peroxidation and ischemic myocardial damage, and it has been suggested that iron is an independent risk factor for myocardial infarction. The authors investigated whether dietary iron is associated with an increased risk of fatal and nonfatal myocardial infarction in the Rotterdam Study, a community-based...article 1999
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Bast, A. (author), Haenen, G.R.M.M. (author), van den Berg, R. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Surprisingly, neither the precise pharmacological effect nor the toxicological profile is usually established for food components. Carotenoids are no exception in this regard. Only limited insight into the pharmacology and toxicology of carotenoids exists. It is known that the antioxidant action of carotenoids is determined by 1. electron...article 1998
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Effect of methylglyoxal on the physico-chemical and biological properties of low-density lipoproteinSchalkwijk, C.G. (author), Vermeer, M.A. (author), Stehouwer, C.D.A. (author), te Koppele, J. (author), Princen, H.M.G. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)In patients with diabetes, non-enzymatic glycation of low-density lipoprotein (LDL) has been suggested to be involved in the development of atherosclerosis. α-Dicarbonyl compounds were identified as intermediates in the non-enzymatic glycation and increased levels were reported in patients with diabetes. We studied the effect of the α-dicarbonyl...article 1998
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Centraal Instituut voor Voedingsonderzoek TNO (author), Oostenbrug, G.S. (author), Mensink, R.P. (author), Al, M.D.M. (author), van Houwelingen, A.C. (author), Hornstra, G. (author)During pregnancy, maternal plasma concentrations of the peroxidation-susceptible polyunsaturated fatty acids (polyenes) increase. In addition, the proportion of polyenes is higher in neonatal plasma than in maternal plasma. To study whether these increased amounts of polyenes affect antioxidant levels, we measured lipid-soluble antioxidants in...article 1998
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- van de Vijver, L.P.L. (author), van Duyvenvoorde, W. (author), Buytenhek, R. (author), van der Laarse, A. (author), Kardinaal, A.F.M. (author), van den Berg, H. (author), Princen, H.M.G. (author) article 1997
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Bast, A. (author), van der Plas, R.M. (author), van den Berg, H. (author), Haenen, G.R.M.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: Beta-carotene has been shown to exhibit a good radical-trapping antioxidant activity in vitro. We were interested to see if dietary β-carotene in combination with various intake levels for vitamin A would also inhibit lipid peroxidation. Design: Sixty male Wistar rats received vitamin A (as retinyl palmitate) for 14 weeks in the diet ...article 1996
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te Velthuis- Wierik, E.J.M. (author), van den Berg, H. (author), Weststrate, J.A. (author), van het Hof, K.H. (author), de Graaf, C. (author), TNO Voeding (author)Objective: Dietary fat intake is higher than recommended in most western countries and is associated with the prevalence of cardiovascular diseases, obesity and cancer. The growing public concern about the adverse effects of a high fat intake has led to an increased availability of 'reduced-fat' products. Consumption of reduced-fat products...article 1996
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Hau, M.-F. (author), Smelt, A.H.M. (author), Bindels, A.J.G.H. (author), Sijbrands, E.J.G. (author), van der Laarse, A. (author), Onkenhout, W. (author), van Duyvenvoorde, W. (author), Princen, H.M.G. (author), Gaubius Instituut TNO (author)In hypertriglyceridemic (HTG) patients the addition of fish oil to the diet causes a marked reduction in the concentration of triglyceride-rich lipoproteins in the serum. To investigate the effects of fish oil on the oxidation resistance of VLDL and LDL in HTG patients, nine male patients received 1 g/d fish oil (containing 55.7% n-3...article 1996
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