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Li, L. (author), Hoefsloot, H. (author), de Graaf, A.A. (author), Acar, E. (author), Smilde, A.K. (author)Background: Analysis of dynamic metabolomics data holds the promise to improve our understanding of underlying mechanisms in metabolism. For example, it may detect changes in metabolism due to the onset of a disease. Dynamic or time-resolved metabolomics data can be arranged as a three-way array with entries organized according to a subjects...article 2022
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Wezeman, R.S. (author), Chiscop, I. (author), Anitori, L. (author), van Rossum, W.L. (author)Compressive sensing is a signal processing technique used to acquire and reconstruct sparse signals using significantly fewer measurement samples. Compressive sensing requires finding the most sparse solution to an underdetermined linear system, which is an NP-hard problem and as a consequence in practise is only solved approximately. In our...conference paper 2022
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- den Boef, P. (author), Cox, P.B. (author), Tóth, R. (author) conference paper 2021
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- Geilen, M.C.W. (author), Skelin, M. (author), van Kampenhout, J.R. (author), Ara, H.A. (author), Basten, T. (author), Stuijk, S. (author), Goossens, K.G.W. (author) bookPart 2020
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Elahi, H. (author), Geilen, M. (author), Basten, T. (author)The timing of discrete-event systems with synchronization is naturally modeled with canonical multi-rate max-plus linear equations. The main objectives of these models are to analyze and control the systems. As a system becomes more complex, determining its canonical model becomes more complicated. Moreover, these systems may change over time...conference paper 2020
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Dileep, D. (author), Michiels, W. (author), Fusco, M. (author), Verhaegh, J. (author), Hetel, L. (author), Richard, J.P. (author)A methodology is proposed to design stabilising and robust fixed-order decentralised controllers for heterogeneous vehicular platoons with Cooperative Adaptive Cruise Control (CACC). We consider Linear Time Invariant (LTI) models with constant time-delays at state, input and output. The closed-loop systems of (identical) local controllers and...conference paper 2019
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Fusco, M. (author), Semsar-Kazerooni, E. (author), Zegers, J.C. (author), Ploeg, J. (author)In this paper, a method to model the decision making system of Connected and Automated Vehicles (CAVs) is discussed. The method is based on an algebra different from the conventional, the so-called Max-Plus algebra. First, a literature-review on the application of Max-Plus algebra in different sectors is presented. Then, the Max-Plus linear...conference paper 2019
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van den Hout, A. (author), Fox, J.P. (author)Longitudinal data can be used to estimate the transition intensities between healthy and unhealthy states prior to death. An illness-death model for history of stroke is presented, where time-dependent transition intensities are regressed on a latent variable representing cognitive function. The change of this function over time is described by...article 2015
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Jolani, S. (author), Debray, T.P.A. (author), Koffijberg, H. (author), van Buuren, S. (author), Moons, K.G.M. (author)Individual participant data meta-analyses (IPD-MA) are increasingly used for developing and validating multivariable (diagnostic or prognostic) risk prediction models. Unfortunately, some predictors or even outcomes may not have been measured in each study and are thus systematically missing in some individual studies of the IPD-MA. As a...article 2015
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Kempker, P.L. (author), Ran, A.C.M. (author), van Schuppen, J.H. (author)Coordinated linear systems are a particular class of hierarchical systems with a top-to-bottom information structure, consisting of a coordinator system and two or more subsystems. This paper deals with the construction and minimality of coordinated linear systems. Construction procedures are given to transform unstructured or interconnected...article 2014
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Kempker, P.L. (author), Ran, A.C.M. (author), van Schuppen, J.H. (author)Coordinated linear systems are a special class of hierarchical linear systems, with a strict top-to-bottom information structure. The LQ problem over all structure-preserving static state feedbacks is discussed. The overall control problem separates into conditionally independent subproblems, a numerical approach to their solution is derived,...article 2014
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Weiss, M. (author), Shtessel, Y. (author)The paper considers the problem of bringing the state of a controllable linear system to the origin in a very short time. It takes the approach of considering an “ideal” control input consisting of a linear combination of the Dirac delta function and its derivatives that realizes this goal instantaneously. Three schemes are introduced to...bookPart 2013
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Sadowska, A. (author), van den Broek, T.H.A. (author), Huijberts, H. (author), van de Wouw, N. (author), Kostić, D. (author), Nijmeijer, H. (author)In this article, the formation control problem for unicycle mobile robots is studied. A distributed virtual structure control strategy with mutual coupling between the robots is proposed. The rationale behind the introduction of the coupling terms is the fact that these introduce additional robustness of the formation with respect to...article 2011
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Bucco, D. (author), Weiss, M. (author), TNO Defensie en Veiligheid (author)The COVAD toolbox is a MATLAB/Simulink based tool conceived and developed for the rapid analysis and simulation of stochastically driven dynamic systems. In addition to a generic Monte Carlo capability, the toolbox is also supported by traditional analytical techniques such as the adjoint and covariance analysis methods. However, these latter...conference paper 2009
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Beerends, J.G. (author), Busz, B. (author), Oudshoorn, P. (author), van Vugt, J. (author), Ahmed, K. (author), Niamut, O. (author), TNO Informatie- en Communicatietechnologie (author)The authors discuss the way we perceive the quality of a speech signal and how different degradations contribute to the overall perceived speech (listening) quality. More specifically, ITU-T Recommendation P.862 (perceptual evaluation of speech quality-PESQ), which provides a perceptual modeling approach with which the subjectively perceived...article 2007
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de Groot, D.M.G. (author), Hartgring, S. (author), van de Horst, L. (author), Moerkens, M. (author), Otto, M. (author), Bos-Kuijpers, M.H.M. (author), Kaufmann, W.S.H. (author), Lammers, J.H.C.M. (author), O'Callaghan, J.P. (author), Waalkens-Berendsen, I.D.H. (author), Pakkenberg, B. (author), Gundersen, H.G. (author), TNO Kwaliteit van Leven (author)To evaluate the ability of a tiered quantitative morphological approach to reveal developmental neurotoxicity, morphometric parameters were measured in the offspring of rats treated with methylazoxymethanol (MAM) during days 13-15 of pregnancy. Treatment was aimed at inhibiting the proliferation phase of hippocampal neurons while leaving...article 2005
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Schellen, A. (author), Ooms, B. (author), van de Lagemaat, D. (author), Vreeken, R. (author), van Dongen, W.D. (author), TNO Voeding (author)A generic method was developed for the fast determination of a wide range of drugs in serum or plasma. The methodology comprises generic solid-phase extraction, on-line coupled to gradient HPLC with tandem mass spectrometric detection (SPE-LC-MS/MS). The individual components of the SPE-LC-MS/MS system were optimized in an integrated approach to...article 2003
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TNO Technische Menskunde (author), Bijl, P. (author), Valeton, J.M. (author), Hogervorst, M.A. (author)The traditional test pattern for end-to-end EO system performance testing in the laboratory has been the static 3- or 4-bar target. This choice was governed by linear systems approach. The introduction of under-sampled imagers such as IRFPAs (infrared focal plane array cameras) has challenged the testing community to develop an alternative test,...conference paper 2001
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Radiologische Dienst TNO (author), van Dijk, J.W.E. (author), Julius, H.W. (author)In constant temperature hot gas TLD systems the heating profile of the TL chip is an exponential function of time. A method is presented which enables glow curve deconvolution for non-linear heating systems. The reproducibility of the heating process of constant temperature hot gas systems can be such that a fast linear optimisation procedure...article 1993