Pages
- 1
- 2
- document
-
van der Ploeg, C. (author), Smit, R. (author), Teerhuis, A. (author), Silvas, E. (author)Developing safe automated vehicles that can be proactive, safe, and comfortable in mixed traffic requires improved planning methods that are risk-averse and that account for predictions of the motion of other road users. To consider these criteria, in this article, we propose a nonlinear model-predictive trajectory generator scheme, which...conference paper 2022
- document
-
van der Eerden, F. (author), van den Berg, F. (author), van Heijningen, A. (author)Noise contours around military training areas are calculated by using: a) the measured source strength for the impulsive sources and b) the calculated sound propagation using a representative set of meteorological situations. For high-energy impulsive sounds the source strength is measured at distances beyond 100 meters, where peak levels are...conference paper 2022
- document
-
Kim, Y. (author), Kim, Y. (author), Hwang, J. (author), van den Broek, T.J. (author), Oh, B. (author), Kim, J.Y. (author), Wopereis, S. (author), Bouwman, J. (author), Kwon, O. (author)Oxidative stress aggravates the progression of lifestyle-related chronic diseases. However, knowledge and practices that enable quantifying oxidative stress are still lacking. Here, we performed a proof-of-concept study to predict the oxidative stress status in a healthy population using retrospective cohort data from Boramae medical center in...article 2021
- document
-
Krone, T. (author), Boessen, R. (author), Bijlsma, S. (author), van Stokkum, R. (author), Clabbers, N.D.S. (author), Pasman, W.J. (author)Background. N-of-1 designs gain popularity in nutritional research because of the improving technological possibilities, practical applicability and promise of increased accuracy and sensitivity, especially in the field of personalized nutrition. This move asks for a search of applicable statistical methods. Objective. To demonstrate the...article 2020
- document
-
Keyvani Janbahan, A. (author), Sadeghian Marnani, H. (author), Goosen, H. (author), van Keulen, F. (author)The origin of amplitude reduction in Tapping Mode Atomic Force Microscopy (TM-AFM) is typically attributed to the shift in resonance frequency of the cantilever due to the nonlinear tip-sample interactions. In this paper, we present a different insight into the same problem which, besides explaining the amplitude reduction mechanism, provides a...article 2018
- document
-
van der Bent, G. (author), de Hek, A.P. (author), van Vliet, F.E. (author)A small-signal model of a Gallium Nitride (GaN) Field Effect Transistor (FET) is created which consists of a compact linear model of the intrinsic gate fingers and an Electro-Magnetic (EM)-based model of the extrinsic part. Accurate scaling of transistor size is obtained which means that larger transistors than supported by standard (foundry)...conference paper 2018
- document
-
de Jong, R. (author), van Buuren, S. (author), Spiess, M. (author)The sensitivity of multiple imputation methods to deviations from their distributional assumptions is investigated using simulations, where the parameters of scientific interest are the coefficients of a linear regression model, and values in predictor variables are missing at random. The performance of a newly proposed imputation method based...article 2016
- document
-
Vlaming, M.L. (author), van Duijn, E. (author), Dillingh, M.R. (author), Brands, R. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Bosgra, S. (author), Burggraaf, J. (author), de Koning, M.C. (author), Fidder, A. (author), Mocking, J.A. (author), Sandman, H. (author), de Ligt, R.A. (author), Fabriek, B.O. (author), Pasman, W.J. (author), Seinen, W. (author), Alves, T. (author), Carrondo, M. (author), Peixoto, C. (author), Peeters, P.A. (author), Vaes, W.H. (author)Preclinical development of new biological entities (NBEs), such as human protein therapeutics, requires considerable expenditure of time and costs. Poor prediction of pharmacokinetics in humans further reduces net efficiency. In this study, we show for the first time that pharmacokinetic data of NBEs in humans can be successfully obtained early...article 2015
- document
-
van der Meer, J.A. (author), Trap, H.C. (author), Noort, D. (author), van der Schans, M.J. (author), TNO Defensie en Veiligheid (author)Recently, several methods have been developed to verify exposure to nerve agents. Most of these methods, such as the fluoride reactivation technique and the analysis of inhibited phosphonylated butyrylcholinesterase (BuChE), are based on mass spectrometry. The high specificity of the mass spectrometer might also imply a disadvantage, because the...article 2010
- document
-
van der Eerden, F.J.M. (author), van der Berg, F. (author)In the densely populated area of the Netherlands, the objective of the Netherlands Ministry of Defence is to find an optimal balance between military training and the impact on the surrounding civilian community. A special case concerns large weapons, such as artillery or demolitions, which create high-energy blast waves. These waves have a low...conference paper 2010
- document
-
van den Ende, D.A. (author), Bos, B. (author), Groen, W.A. (author), TNO Industrie en Techniek (author)Piezoelectric bimorph bender actuators find application number of areas, ranging from automotive to health care. High voltage operation in harsh environments poses ever more stringent demands on functionality and lifetime. In these high performance benders, the trade-off between functionality and lifetime becomes of increasing importance, and a...article 2009
- document
-
Hrapko, M. (author), van Dommelen, J.A.W. (author), Peters, G.W.M. (author), Wismans, J.S.H.M. (author), TNO Industrie en Techniek (author)The objective of this work was to investigate the influences of constitutive non linearities of brain tissue in numerical head model simulations by comparing the performance of a recently developed non linear constitutive model [10, 11] with a simplified version, based on neo-Hookean elastic behaviour, and with a previously developed...article 2009
- document
-
Wang, J. (author), van der Heijden, R. (author), Spijksma, G. (author), Reijmers, T. (author), Wang, M. (author), Xu, G. (author), Hankemeier, T. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)A matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) method was developed for the high throughput and robust qualitative profiling of alkaloids in Fuzi-the processed lateral roots of the Chinese herbal medicine Aconitum carmichaeli Debx (A. carmichaeli). After optimization, powdered roots - without any further sample...article 2009
- document
-
Eijkemans, M. (author), Mommers, M. (author), de Vries, S.I. (author), van Buuren, S. (author), Stafleu, A. (author), Bakker, I. (author), Thijs, C. (author), TNO Kwaliteit van Leven (author)OBJECTIVE. Prevalence of asthma and overweight has increased simultaneously during the past decades. Several studies have reported an association between these two health problems, but it is unclear whether this relation is causal. We hypothesize that children with asthmatic symptoms are less physically active, which may contribute to the...article 2008
- document
-
Hughes, L.A.E. (author), Arts, I.C.W. (author), Ambergen, T. (author), Brants, H.A.M. (author), Dagnelie, P.C. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), Weijenberg, M.P. (author), TNO Kwaliteit van Leven (author)Background: Dietary flavonoids are suggested to have antiobesity effects. Prospective evidence of an association between flavonoids and body mass index (BMI) is lacking in general populations. Objective: We assessed this association between 3 flavonoid subgroups and BMI over a 14-y period in 4280 men and women aged 55-69 y at baseline from the...article 2008
- document
-
van den Berg, J.F. (author), Knvistingh Neven, A. (author), Tulen, J.H.M. (author), Hofman, A. (author), Witteman, J.C.M. (author), Miedema, H.M.E. (author), Tiemeier, H. (author), TNO Bouw en Ondergrond (author)Objective: The epidemiological evidence for the association between sleep duration and obesity in the elderly is inconsistent and has not been investigated with objective measures. Furthermore, the role of sleep fragmentation in this relationship is unknown. Our aim was to investigate the association of sleep measures with body mass index (BMI)...article 2008
- document
-
van der Eerden, F.J.M. (author), van den Berg, F. (author), van 't Hof, J. (author), van Arkel, E. (author), TNO Industrie en Techniek (author)A blast absorber test was conducted at the Aberdeen Test Centre from 13 to 17 June 2005. The test was set up to determine the absorbing and shielding effect of a gravel pile, of 1.5 meters high and 15 by 15 meters wide, on blasts from large weapons: e.g. armor, artillery or demolition. The blast was simulated with single brick C-4 charges of 570...conference paper 2006
- document
-
Perenboom, R.J.M. (author), van Herten, L.M. (author), Boshuizen, H.C. (author), van den Bos, G.A.M. (author)Objective. Life expectancy without chronic morbidity, or morbidity-free life expectancy (MFLE), was calculated to measure changes in population health status between 1989 and 2000 on the basis of gender and socioeconomic status. Methods. Sullivan's method was used to calculate morbidity-free life expectancy. Prevalence rates for chronic...article 2005
- document
-
Steenstra, I.A. (author), Koopman, F.S. (author), Knol, D.L. (author), Kat, E. (author), Bongers, P.M. (author), de Vet, H.C.W. (author), van Mechelen, W. (author), TNO Kwaliteit van Leven (author)Information on prognostic factors for duration of sick leave due to low-back pain (LBP) is growing. In this prospective cohort study, prognostic factors for duration of sick leave and course of disability were identified at a very early stage of sick leave due to LBP. A total of 615 workers calling in sick from work due to LBP at an occupational...article 2005
- document
-
Bos, J.E. (author), MacKinnon, S.N. (author), Patterson, A. (author), TNO Defensie en Veiligheid (author)Vehicle motion characteristics differ between air, road, and sea environments, both vestibularly and visually. Effects of vision on motion sickness have been studied before, though less systematically in a naval setting. It is hypothesized that appropriate visual information on self-motion is beneficial in a naval setting and that task...article 2005
Pages
- 1
- 2