Searched for: subject:"Life"
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Schlunk, F. (author), Fisher, P. (author), Princen, H.M.G. (author), Rex, A. (author), Prinz, V. (author), Foddis, M. (author), Lütjohann, D. (author), Laufs, U. (author), Endres, M. (author)
Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PSCK9) neutralizing antibodies effectively lower plasma cholesterol levels and decrease cardiovascular events but also raised some concern that cognitive function could worsen as a side effect. Here, we performed experiments in mice to characterize the effect of anti-PCSK9 antibodies...
article 2021
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Goemans, B.F. (author), Noort, S. (author), Blink, M. (author), Wang, Y.D. (author), Peters, S.T.C.J. (author), van Wouwe, J.P. (author), Kaspers, G. (author), de Haas, V. (author), Kollen, W.J. (author), van der Velden, V.H.J. (author), Gruber, T.A. (author), Zwaan, C.M. (author)
The aim of this study was to define a population-based frequency of TAM in DS newborns. The Dutch Pediatric Surveillance Unit (DPSU) registers newborns with DS and TAM screening was added to this registration from Jan 1, 2008, until Jan 1, 2013 (Erasmus MC MEC-2007-168, Netherlands Trial Register NL1587). Based on the live birth prevalence of DS...
article 2021
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Kaptein, F. (author), Broekens, J. (author), Hindriks, K. (author), Neerincx, M.A. (author)
Current developments in Artificial Intelligence (AI) led to a resurgence of Explainable AI (XAI). New methods are being researched to obtain information from AI systems in order to generate explanations for their output. However, there is an overall lack of valid and reliable evaluations of the effects on users' experience of, and behavior in...
article 2021
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Pablo Sigüenza, C.P. (author), Cucurachi, S. (author), Tukker, A. (author)
Among European countries, The Netherlands is boosting the transformation to a circular economy creat- ing and deploying circular business models across different sectors, including the home appliances sector. Although in recent years shared access-based business models have attracted the attention of the scien- tific community from a...
article 2021
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Hooftman, W.E. (author), van Dam, L.M.C. (author)
De COVID-19 pandemie heeft voor een forse toename van tijd- en plaatsonafhankelijk werken gezorgd. Maar dit proces was al eerder in gang gezet. Uit de Arbobalans 2020 blijkt dat het aandeel werknemers dat tijden plaatsonafhankelijk kan werken tussen 2014 en 2019 is toegenomen. Vakmedianet
article 2021
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Blom, W.M. (author), van Dijk, L.M. (author), Michelsen-Huisman, A. (author), Houben, G.F. (author), Knulst, A.C. (author), Linders, Y.F.M. (author), Verhoeckc, K.C.M. (author), Holleman, B.C. (author), Lentz, L.R. (author)
Background: Allergen information on product labels is crucial in food allergy management, though inadequacy in current labelling practices is one of the major causes for accidental reactions upon consuming prepacked food products. Objective: This study analyses current status of communicating allergen information on food labels and provides...
article 2021
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Wetselaar, P. (author), Vermaire, E.J.H. (author), Lobbezoo, F. (author), Schuller, A.A. (author)
Objectives: This study aimed to assess the prevalence of awake bruxism and sleep bruxism in the Dutch adolescent population. Materials and methods: As part of a large epidemiologic survey on oral health of the general Dutch adolescent population in 2017, a total of 920 subjects were asked about their bruxism behaviour during daytime and during...
article 2021
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Ligthart, M.E.U. (author), Neerincx, M.A. (author), Hindriks, K.V. (author)
While interacting with a social robot, children have a need to express themselves and have their expressions acknowledged by the robot. A need that is often unaddressed by the robot, due to its limitations in understanding the expressions of children. To keep the child-robot interaction manageable the robot takes control, undermining children's...
conference paper 2021
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Deksren, G.C.H. (author), Holthoon, F.L. (author), Willemen, H.M. (author), Krul, C.A.M. (author), Franssen, M.C.R. (author), van Beek, T.A. (author)
Madder, used as a red dye, contains anthraquinones, and some of these can react with DNA possibly causing mutagenic effects. This is especially true for 1,3-dihydroxyanthraquinones with a hydroxymethyl (e.g., lucidin 6, ibericin 10) or methyl group (e.g., rubiadin 9) at C-2. In this research, a new process was developed through which the...
article 2021
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van Zoelen, E.M. (author), van den Bosch, K. (author), Neerincx, M.A. (author)
A team develops competency by progressive mutual adaptation and learning, a process we call co-learning. In human teams, partners naturally adapt to each other and learn while collaborating. This is not self-evident in human-robot teams. There is a need for methods and models for describing and enabling co-learning in human-robot partnerships....
conference paper 2021
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Schwarz, A.E. (author), Ligthart, T.N. (author), Godoi Bizarro, D.E. (author), de Wild, P.J. (author), Vreugdenhil, B.J. (author), van Harmelen, A.K. (author)
To ensure a circular economy for plastics, insights in the environmental impacts of recycling and optimal recycling choices for specific plastic polymers are crucial. This was obtained by determining the environmental performance of 10 selected recycling technologies with varying TRL levels, using the chemical properties of the top 25 produced...
article 2021
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Rijnders, M. (author), Jans, S (author), Groesen, K. (author)
Reduced antenatal care services and an acute halt to Centeringbased antenatal group care were one of the results of the COVID-19 lockdown in the Netherlands. The pandemic and the subsequent reduction in antenatal services gave rise to anxiety and stress in pregnant women, increasing the need for group antenatal care more than ever. Throughout...
article 2021
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van der Ploeg, C.P.B. (author), Grevinga, M. (author), Eekhout, I. (author), Vlasblom, E. (author), Lanting, C.I. (author), van Minderhout, H.M. (author), Dijk-van der Poel, J. (author), van den Akker-van Marle, M.E. (author), Verkerk, P.H. (author)
Background: Little is known about costs and effects of vision screening strategies to detect amblyopia. Aim of this study was to compare costs and effects of conventional (optotype) vision screening, photoscreening or a combination in children aged 3-6 years. Methods: Population-based, cross-sectional study in preventive child health care in The...
article 2021
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Naafs, J.C. (author), Marchal, J.P. (author), Verkerk, P.H. (author), Fliers, E. (author), van Trotsenburg, A.S.P. (author), Zwaveling-Soonawala, N. (author)
Context. Central congenital hypothyroidism (CH) requires lifelong medical treatment. The majority of children with central CH have multiple pituitary hormone deficiencies (MPHD), but in some cases central CH is isolated. Most pituitary hormone deficiencies are associated with impaired health-related quality of life (HRQoL). However, studies on...
article 2021
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Vooijs, M. (author), van Kesteren, N. (author), Hazelzet, A.M. (author), Otten, W. (author)
Background: Work participation is an important determinant of public health; being unemployed leads to a decrease in an individual's health. In the Netherlands, people with a work disability can apply for disability benefits, in which people also receive support to return to work (RTW). A method, currently used in the medical sector, that can...
article 2021
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Gopaul, V.S. (author), Pieterman, E.J. (author), Princen, H.M.G. (author), Bergenholm, L. (author), Lundborg, E. (author), Cavallin, A. (author), Johansson, M.J. (author), Hawthorne, G. (author), Björkbom, A. (author), Hammarberg, M. (author), Li, X. (author), Jarke, A. (author), Bright, J. (author), Svensson, L. (author), Jansson-Löfmark, R. (author), Abrahamsson, B. (author), Agrawal, R. (author), 1 Hurt-Camejo, E. (author)
We investigated the effects of mineral oil on statin pharmacokinetics and inflammatory markers in animal models. A new synthesis strategy produced regioisomers that facilitated the characterization of the main metabolite (M1) of atorvastatin, a lipophilic statin, in C57BL/6NCrl mice. The chemical structure of M1 in mice was confirmed as ortho...
article 2021
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Hooftman, W.E. (author), van Dam, L.M.C. (author)
De ervaren fysieke zwaarte van het werk is toegenomen tijdens de covid-19 pandemie. In november 2020 gaf ruim 18 procent van de werknemers die tijdens de Covid-19 pandemie op locatie bleven werken aan dat het werk door de maatregelen lichamelijk zwaarder voelt dan normaal. Werknemers die volledig op locatie werken (21%) vinden relatief vaker dat...
article 2021
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Hooftman, W.E. (author), van Dam, L.M.C. (author)
Het aandeel werknemers met burnoutklachten is tussen 2014 en 2018 toegenomen van 14 naar 17 procent, om daarna te stabiliseren. Ook tijdens de covid-19 pandemie blijft het aandeel werknemers met burn-outklachten redelijk stabiel. Vakmedianet
article 2021
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van der Ploeg, C.P.B. (author), Grevinga, M. (author), Eekhout, I. (author), Vlasblom, E. (author), Lanting, C.I. (author), van Minderhout, H.M. (author), Dijk-van der Poel, J. (author), van den Akker-van Marle, M.E. (author), Verkerk, P.H. (author)
Comment on the article: Costs and effects of conventional vision screening and photoscreening in the Dutch preventive child health care system. We thank professor Simonsz for his comments, since it gives us the opportunity to clarify some of our findings. Indeed, with the price for the photoscreening device of €2.29 per child as calculated in...
article 2021
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Bizarro, D.E.G. (author), Steinmann, Z. (author), Nieuwenhuijse, I. (author), Keijzer, E. (author), Hauck, M. (author)
article 2021
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