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Remels, A.H.V. (author), Derks, W.J.A. (author), Cillero-Pastor, B. (author), Verhees, K.J.P. (author), Kelders, M.C. (author), Heggermont, W. (author), Carai, P. (author), Summer, G. (author), Ellis, S.R. (author), de Theije, C.C. (author), Heeren, R.M.A. (author), Heymans, S. (author), Papageorgiou, A.P. (author), van Bilsen, M. (author)Acute viral myocarditis (VM), characterised by leukocyte infiltration and dysfunction of the heart, is an important cause of sudden cardiac death in young adults. Unfortunately, to date, the pathological mechanisms underlying cardiac failure in VM remain incompletely understood. In the current study, we investigated if acute VM leads to cardiac...article 2018
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Kooter, I.M. (author), Grollers-Mulderij, M. (author), Duistermaat, E. (author), Kuper, C.F. (author)Mucilair 3D bronchial airway models, cultured at an air-liquid interface, were exposed to aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules. Four cell donors, four exposure modules and four exposure concentrations were varied within four different exposure sessions using a statistical experimental design called a...article 2017
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- de Jong, T. (author), Kamphuis, M. (author), Kivit-Schwengle, L. (author) article 2014
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Wolterbeek, A.P.M. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Piersma, A.H. (author), van Loveren, H. (author)The susceptibility of developing immune system to chemical disruption warrants the assessment of immune parameters in reproductive and developmental testing protocols. In this study, a wide range of immune endpoints was included in an extended one-generation reproduction toxicity study (EOGRTS) design to determine the relative sensitivity of...article 2013
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Bastiaansen-Jenniskens, Y.M. (author), Siawash, M. (author), van de Lest, C.H.A. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), van Osch, G.J.V.M. (author), Clockaerts, S. (author)Purpose: Osteoarthritis (OA) is associated with obesity in which altered fatty acid levels have been observed. We investigated whether the most common fatty acids in synovial fluid influence cartilage deterioration in OA. Design: Cartilage was obtained from OA patients undergoing total knee arthroplasty. Chondrocytes or cartilage explants were...article 2013
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Menke, A. (author), Wolterbeek, A. (author), Snel, C. (author), Bruijntjes, J. (author), Groot, D.D. (author), Oostrum, L.V. (author), Waalkens, I. (author), Kuper, C.F. (author)Characteristic susceptibility to environmental and pharmaceutical exposure may occur during periods in life of marked histophysiological changes of the immune system. Perinatal development is such a period; pregnancy followed by lactation is potentially another one. Here, we explored the influence of pregnancy and lactation on the model...article 2012
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van Wouwe, J.P. (author), Lanting, C.I. (author), van Dommelen, P. (author), Treffers, P.E. (author), van Buuren, S. (author), TNO Kwaliteit van Leven (author)Aim: The aim of this study was to gain insight into contraception practised and related to breastfeeding duration. Methods: Mothers with infants up to 6 months received a questionnaire on infant feeding (breast or formula feeding) and contraception (hormonal or non-hormonal methods). Estimates of the time interval between resuming contraception...article 2009
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Wierckx, N. (author), Ruijssenaars, H.J. (author), de Winde, J.H. (author), Schmid, A. (author), Blank, L.M. (author), TNO Kwaliteit van Leven (author)The physiological effects of genetic and transcriptional changes observed in a phenol producing mutant of the solvent-tolerant Pseudomonas putida S12 were assessed with metabolic flux analysis. The upregulation of a malate/lactate dehydrogenase encoding gene could be connected to a flux increase from malate to oxaloacetate. A mutation in the...article 2009
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Hellebrekers, B.W.J. (author), Trimbos-Kemper, T.C.M. (author), Boesten, L. (author), Jansen, F.W. (author), Kolkman, W. (author), Trimbos, J.B. (author), Press, R.R. (author), van Poelgeest, M.I.E. (author), Emeis, S.J. (author), Kooistra, T. (author), TNO Kwaliteit van Leven (author)Objective: To identify predictors of postsurgical adhesion formation in peritoneal fluid and plasma, and assess efficacy and safety of reteplase (recombinant plasminogen activator [r-PA]). Design: Prospective randomized study. Setting: University Medical Center. Patient(s): Twenty-six abdominal myomectomy patients with early second-look...article 2009
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He, T. (author), Venema, K. (author), Priebe, M.G. (author), Welling, G.W. (author), Brummer, R.J.M. (author), Vonk, R.J. (author), TNO Kwaliteit van Leven (author), KvL (author)Lactose maldigestion and intolerance affect a large part of the world population. The underlying factors of lactose intolerance are not fully understood. In this review, the role of colonic metabolism is discussed, i.e. fermentation of lactose by the colonic microbiota, colonic processing of the fermentation metabolites and how these processes...article 2008
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Kuper, C.F. (author), van Zijverden, M. (author), Klaassen, C. (author), Tegelenbosch-Schouten, M. (author), Wolterbeek, A.P.M. (author), TNO Kwaliteit van Leven (author)The effects of cyclosporin A (CY) and cyclophosphamide (CPS) on Peyer's patches (PP) were studied in Wistar rats, exposed in utero and neonatally or during adult age. In one study, pregnant dams received 5 or 15 mg/kg bw/day CY from gestation day 6 to day 21 of lactation. In two other studies, animals were exposed at young adult age: female rats...article 2007
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TNO Kwaliteit van Leven (author), Rist, L. (author), Mueller, A. (author), Barthel, C. (author), Snijders, B. (author), Jansen, M. (author), Simões-Wüst, A.P. (author), Huber, M. (author), Kummeling, I. (author), von Mandach, U. (author), Steinhart, H. (author), Thijs, C. (author)The aim of the present study was to find out whether the incorporation of organic dairy and meat products in the maternal diet affects the contents of the conjugated linoleic acid isomers (CLA) and trans-vaccenic acid (TVA) in human breast milk. To this purpose, milk samples from 312 breastfeeding mothers participating in the KOALA Birth Cohort...article 2007
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Lina, B.A.R. (author), Wolterbeek, A.P.M. (author), Suwa, Y. (author), Fujikawa, S. (author), Ishikura, Y. (author), Tsuda, S. (author), Dohnalek, M. (author), TNO Kwaliteit van Leven (author)Polyunsaturated fatty acids (PUFAs), such as arachidonic acid (ARA) and docosahexaenoic acid (DHA) are natural constituents found in human milk, fish oil or egg yolk. Until recently, infant formulas, though providing the essential fatty acid precursors for these PUFAs, did not contain preformed ARA or DHA. In this study the safety of SUNTGA40S...article 2006
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Belstra, B.A. (author), Flowers, W.L. (author), Croom, W.J. (author), de Groot, J. (author), See, M.T. (author), TNO Preventie en Gezondheid (author)Incomplete uterine involution is the putative cause of the increased embryo mortality and reproductive failure often exhibited by sows that lactate for less than 21 days. Since such short lactation lengths are common in American swine production, an effective technique to monitor the postpartum involution process and test this hypothesis might...article 2005
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Vreugdenhil, H.J.I. (author), Emmen, H.H. (author), Mulder, P.G.H. (author), Weisglas-Kuperus, N. (author), TNO Voeding (author)PCBs are known for their neurotoxic properties, especially on the developing brain. To increase insight into the neurotoxic effects of PCB exposure, the authors studied the effects of perinatal exposure to environmental levels of these compounds on different neuropsychological domains. In 9-year-old children of the Rotterdam PCB-dioxin cohort,...article 2004
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Arts, J.H.E. (author), Bloksma, N. (author), Leusink-Muis, T. (author), Kuper, C.F. (author)Occupational exposure to low-molecular-weight (LMW) allergens such as acid anhydrides can result in occupational asthma, an allergic disease characterized by episodic airway obstruction, airways inflammation, and non specific airways hyperresponsiveness. Since LMW irritants can provoke rather similar effects and since most, if not all, LMW...article 2003
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Stekelenburg, F.K. (author), TNO Voeding (author)Frankfurter-type sausages were prepared with potassium lactate, sodium diacetate and various levels of a mixture of potassium lactate and sodium diacetate. The development of Lactobacillus sake and Listeria monocytogenes and the sensory quality were compared with a reference product without any of these additions. It was shown that addition of 2...article 2003
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Clary, J.J. (author), Feron, V.J. (author), van Velthuijsen, J.A. (author), TNO Voeding (author)Organo psycho syndrome (OPS) or chronic toxic encephalopathy (CTE) is a neurotoxic condition reported following long-term exposure to paints containing organic solvent and to other solvents. Lactate esters are finding wider use as solvents. Lactate esters have been well studied in standard toxicity tests, but specific neurotoxicity studies have...article 2001
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Stekelenburg, F.K. (author), Knat-Muermans, M.L.T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Cooked cured ham products were produced according to a standard recipe for cooked ham with various levels of sodium lactate, sodium diacetate or buffered sodium citrate. They were compared with a reference ham product with respect to sensory quality and growth of Lactobacillus curvatus and Listeria monocytogenes. For this, a part of the products...article 2001
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Reichl, F.X. (author), Walther, U.I. (author), Durner, J. (author), Kehe, K. (author), Hickel, R. (author), Kunzelmann, K.H. (author), Spahl, W. (author), Hume, W.R. (author), Benschop, H.P. (author), Forth, W. (author)Objective: The effect of dental composite components triethyleneglycoldimethacrylate (TEGDMA) and hydroxyethylmethacrylate (HEMA), as well as mercuric chloride (HgCl2) and methylmercury chloride (MeHgCl) was investigated on the release of lactatedehydrogenase (LDH) from alveolar epithelial lung cell lines in vitro. Methods: The confluent cell...article 2001