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Straat, C. (author), Maarleveld, J.M. (author), Smit, D.J.M. (author), Visch, L, (author), Hulsegge, G. (author), Huirne, J.A.F. (author), van Dongen, J.M. (author), van Geenen, R.C. (author), Kerkhoff, G.M.M.J. (author), Anema, J.R. (author), Coenen, P. (author), Kuijer, P.P.F.M. (author)Background: With the worldwide rising obesity epidemic and the aging population, it is essential to deliver (cost-)effective care that results in enhanced societal participation among knee arthroplasty patients. The purpose of this study is to describe the development, content, and protocol of our (cost-)effectiveness study that assesses a...article 2023
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Kim, C. (author), Colborn, K. (author), van Buuren, S. (author), Loar, T. (author), Stevens-Lapsley, J.E. (author), Kittelson, A.J. (author)The purpose of this study was to develop and test personalized predictions for functional recovery after Total Knee Arthroplasty (TKA) surgery, using a novel neighbors-based prediction approach. We used data from 397 patients with TKA to develop the prediction methodology and then tested the predictions in a temporally distinct sample of 202...article 2021
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Kloek, C.J.J. (author), Bossen, D. (author), de Vries, H.J. (author), de Bakker, D.H. (author), Veenhof, C. (author), Dekker, J. (author)E-Exercise is an effective 12-week blended intervention consisting of around five face-to-face physiotherapy sessions and a web-based application for patients with hip/knee osteoarthritis. In order to facilitate effective implementation of e-Exercise, this study aims to identify physiotherapists' experiences and determinants related to the usage...article 2020
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Coenen, P. (author), Hulsegge, G. (author), Daams, J.G. (author), van Geenen, R.G. (author), Kerkhoffs, G.M. (author), van Tulder, M.W. (author), Huirne, J.A. (author), Anema, J.R. (author), Kuijser, P.P. (author)Objectives Orthopaedic surgery is primarily aimed at improving function and pain reduction. Additional integrated care may enhance patient’s participation in sports and work, possibly improving performance of physical activities and quality of life (QoL). We aimed to assess the effectiveness of integrated care among orthopaedic surgery patients....article 2020
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Straat, A.C. (author), Coenen, P. (author), Smit, D.J.M. (author), Hulsegge, G. (author), Bouwsma, E.V.A. (author), Huirne, J.A. (author), van Geenen, R.G. (author), Janssen, R.P.A. (author), Boymans, T.A.E.J. (author), Kerkhoffs, G.M. (author), Anema, J.R. (author), Kuijer, P.P.E.M. (author)Evidence for recommendations concerning the resumption of activities of daily life, including work and sport, after knee arthroplasty is lacking. Therefore, recommendations vary considerably between hospitals and healthcare professionals. We aimed to obtain multidisciplinary consensus for such recommendations. Using a Delphi procedure, we...article 2020
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Bongers, C.C.W.G. (author), ten Haaf, D.S.M. (author), Catoire, M. (author), Kersten, B. (author), Wouters, J.A. (author), Eijsvogels, T.M.H. (author), Hopman, M.T.E. (author)The purpose of this study was to examine the effects of 12 weeks collagen peptide (CP) supplementation on knee pain and function in individuals with self-reported knee pain. Healthy physically active individuals (n = 167, aged 63 [interquartile range = 56-68] years) with self-reported knee pain received 10 g/day of CP or placebo for 12 weeks....article 2020
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Kittelson, A. (author), Elings, J. (author), Colborn, K. (author), Hoogeboom, T.J. (author), Christensen, J.C. (author), van Meeteren, N.L.U. (author), van Buuren, S. (author), Stevens-Lapsley, J.E. (author)Background: Clinicians and patients lack an evidence-based framework by which to judge individual-level recovery following total knee arthroplasty (TKA) surgery, thus impeding personalized treatment approaches for this elective surgery. Our study aimed to develop and validate a reference chart for monitoring recovery of knee flexion following...article 2020
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Holden, M.A. (author), Burke, D.L. (author), Runhaar, J. (author), van der Windt, D. (author), Riley, R.D. (author), Dziedzic, K. (author), Legha, A. (author), Evans, A.L. (author), Abbott, J.H. (author), Baker, K. (author), Brown, J. (author), Bennell, K.L. (author), Bossen, D. (author), Brosseau, L. (author), Chaipinyo, K. (author), Christensen, R. (author), Cochrane, T, (author), de Rooij, M. (author), Doherty, M. (author), French, H.P. (author), Hickson, S. (author), Hinman, R.S. (author), Hopman-Rock, M. (author), Hurley, M.V. (author), Ingram, C. (author), Knoop, J. (author), Krauss, I., (author), McCarthy, C. (author), Messier, S.P. (author), Patrick, D.L. (author), Sahin, N. (author), Talbot, L.A. (author), Taylor, R. (author), Teirlinck, C.H. (author), van Middelkoop, M. (author), Walker, C. (author), Foster, N.E. (author)INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physical function are small to moderate. This may be due to insufficient targeting of exercise to...article 2017
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van Tiel, J. (author), Siebelt, M. (author), Reijman, M. (author), Bos, P.K. (author), Waarsing, J.H. (author), Zuurmond, A.M. (author), Nasserinejad, K. (author), van Osch, G.J.V.M. (author), Verhaar, J.A.N. (author), Krestin, G.P. (author), Weinans, H. (author), Oei, E.H.G. (author)Objective. Recently, computed tomography arthrography (CTa) was introduced as quantitative imaging biomarker to estimate cartilage sulphated glycosaminoglycan (sGAG) content in human cadaveric knees. Our aim was to assess the correlation between in vivo CTa in human osteoarthritis (OA) knees and ex vivo reference standards for sGAG and collagen...article 2016
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Klein-Wieringa, I.R. (author), de Lange-Brokaar, B.J. (author), Yusuf, E. (author), Andersen, S.N. (author), Kwekkeboom, J.C. (author), Kroon, H.M. (author), van Osch, G.J. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Nelissen, R.G. (author), Toes, R.E. (author), Kloppenburg, M. (author), Ioan-Facsinay, A. (author)Objective: To get a better understanding of inflammatory pathways active in the osteoarthritic (OA) joint, we characterized and compared inflammatory cells in the synovium and the infrapatellar fat pad (IFP) of patients with knee OA. Methods: Infiltrating immune cells were characterized by flow cytometry in 76 patients with knee OA (mean age 63...article 2016
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Differences in injury risk and characteristics between Dutch amateur and professional soccer playersvan Beijsterveldt, A.M.C. (author), Stubbe, J.H. (author), Schmikli, S.L. (author), van de Port, I.G.L. (author), Backx, F.J.G. (author)Objectives: To compare the incidence and characteristics of injuries between Dutch amateur and professional male soccer players during one entire competition season. Design: A prospective two-cohort design. Methods: During the 2009-2010 season, 456 Dutch male amateur soccer players and 217 professional players were prospectively followed....article 2015
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de Lange-Brokaar, B.J.E. (author), Ioan-Facsinay, A. (author), Yusuf, E. (author), Visser, A.W. (author), Kroon, H.M. (author), van Osch, G.J.V.M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Bloem, J.L. (author), Nelissen, R.G.H.H. (author), Huizinga, T.W. (author), Kloppenburg, M. (author)Objective To determine possible patterns of synovitis on contrast-enhanced magnetic resonance imaging (CE-MRI) and its relation to pain and severity in patients with radiographic knee osteoarthritis (OA). Methods In total, 86 patients (mean age 62 years, 66% women, median body mass index 29 kg/m2) with symptomatic knee OA (Kellgren/Lawrence...article 2015
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Hoogeboom, T.J. (author), van Meeteren, N.L.U. (author), Schank, K. (author), Kim, R.H. (author), Miner, T. (author), Stevens-Lapsley, J.E. (author)Purpose. To determine the predictive value of surgery-related variables for delayed inpatient functional recovery (i.e., ≥3 days to reach functional independence) after TKA. Method. 193 consecutive people undergoing TKA were included in this prospective cohort study. Inpatient functional recovery was measured daily using the Iowa Level of...article 2015
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van der Sluis, G. (author), Goldbohm, R.A. (author), Bimmel, R. (author), Galindo Garre, F. (author), Eling, J. (author), Hoogeboom, T.J. (author), van Meeteren, N.L.U. (author)Background. In the routine setting of the 20-bed orthopaedic ward of a regional hospital in Netherlands, we developed, implemented, and evaluated a new, function-tailored perioperative care pathway for patients receiving total knee replacement (TKR), aimed at faster functional recovery by reduction of inactivity and stimulation of self-efficacy...article 2015
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van Beijsterveldt, A.M.C. (author), van der Knaap, E.T.W. (author), Jongert, M.W.A. (author), Backx, F.J.G. (author), Stubbe, J.H. (author)De doelen van dit onderzoek zijn het in kaart brengen van voetbalblessures bij Nederlandse prof- en amateurvoetballers en in het bijzonder knieblessures. Tijdens seizoen 2009-2010 zijn 673 mannelijke voetballers prospectief gevolgd. Van hen is zowel indivuduele expositie (aantal minuten besteed aan traininge en wedstrijden) als informatie over...article 2014
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de Lange-Brokaar, B.J.E. (author), Ioan-Facsinay, A. (author), Yusuf, E. (author), Visser, A.W. (author), Kroon, H.M. (author), Andersen, S.N. (author), Herb-van Toorn, L. (author), van Osch, G.J.V.M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), Bloem, J.L. (author), Nelissen, R.G.H.H. (author), Huizinga, T.W.J. (author), Kloppenburg, M. (author)Objective: To evaluate the association between synovitis on contrast enhanced (CE) MRI with microscopic and macroscopic features of synovial tissue inflammation. Method: Forty-one patients (mean age 60 years, 61% women) with symptomatic radiographic knee OA were studied: twenty underwent arthroscopy (macroscopic features were scored (0-4),...article 2014
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Gierman, L.M. (author), Kühnast, S. (author), Koudijs, A. (author), Pieterman, E.J. (author), Kloppenburg, M. (author), van Osch, G.J.V.M. (author), Stojanovic-Susulic, V. (author), Huizinga, T.W.J. (author), Princen, H.M.G. (author), Zuurmond. A.M., (author)Objective Hypercholesterolaemia, a risk factor for atherosclerosis (ATH), has been suggested to have a role in the development of osteoarthritis (OA). To test this hypothesis, the effect of cholesterol and different cholesterol-lowering treatments on OA was investigated in a mouse model resembling human lipoprotein metabolism. Methods Female...article 2014
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Bastiaansen-Jenniskens, Y.M. (author), Siawash, M. (author), van de Lest, C.H.A. (author), Verhaar, J.A.N. (author), Kloppenburg, M. (author), Zuurmond, A.M. (author), Stojanovic-Susulic, V. (author), van Osch, G.J.V.M. (author), Clockaerts, S. (author)Purpose: Osteoarthritis (OA) is associated with obesity in which altered fatty acid levels have been observed. We investigated whether the most common fatty acids in synovial fluid influence cartilage deterioration in OA. Design: Cartilage was obtained from OA patients undergoing total knee arthroplasty. Chondrocytes or cartilage explants were...article 2013
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de Lange-Brokaar, B.J.E. (author), Ioan-Facsinay, A. (author), van Osch, G.J.V.M. (author), Zuurmond, A.-M. (author), Schoones, J. (author), Toes, R.E.M. (author), Huizinga, T.W.J. (author), Kloppenburg, M. (author)Objective: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is widely accepted that synovial inflammation is a feature of OA. However, the role of immune cells and their cytokines in OA is largely unknown. This narrative systematic review summarizes the knowledge of inflammatory properties, immune cells and their...article 2012
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Vos, P.A.J.M. (author), Mastbergen, S.C. (author), Huisman, A.M. (author), de Boer, T.N. (author), de Groot, J. (author), Polak, A.A. (author), Lafeber, F.P.J.G. (author)Objectives: Age is the most prominent predisposition for development of osteoarthritis (OA). Age-related changes of articular cartilage are likely to play a role. Advanced glycation endproducts (AGEs) accumulate in cartilage matrix with increasing age and adversely affect the biomechanical properties of the cartilage matrix and influence...article 2012