Impact of different climatic conditions on peak core temperature of elite athletes during exercise in the heat: a Thermo Tokyo simulation study

Objectives To evaluate how separate and combined climatic parameters affect peak core temperature during exercise in the heat using computer simulations fed with individual data. Methods The impact of eight environmental conditions on rectal temperature (Tre) was determined for exercise under heat stress using the Fiala-thermal-Physiology-and...

Proposed framework for forecasting heat-effects on motor-cognitive performance in the Summer Olympics

Ambient conditions prior to Tokyo 2020 Olympic and Paralympic games: Considerations for acclimation or acclimatization strategies

The Tokyo Olympics and Paralympic games in 2020 will be held in hot and humid conditions. Heat acclimation (in a climatic chamber) or heat acclimatization (natural environment) is essential to prepare the (endurance) athletes and reduce the performance loss associated with work in the heat. Based on the 1990-2018 hourly meteorological data of...

Natural versus anthropogenic inhalable aerosol chemistry of transboundary East Asian atmospheric outflows into western Japan

The eastward transport of aerosols exported from mainland Asia strongly influences air quality in the Japanese archipelago. The bulk of the inhalable particulate matter (PM10) in these intrusions comprises either natural, desert-derived minerals (mostly supermicron silicates) or anthropogenic pollutants (mostly submicron sulphates), in various...

Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma

We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations. © 2006 Cancer Research. Chemicals / CAS: adenine, 22177-51-1, 2922-28...

Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis

Francisella tularensis is a potent pathogen and a possible bioterrorism agent. Little is known, however, to explain the molecular basis for its virulence and the distinct differences in virulence found between the four recognized subspecies, F. tularensis subsp. tularensis, F. tularensis subsp. mediasiatica, F. tularensis subsp. holarctica, and...

Intelligent manufacturing through participation: a participative simulation environment for integral manufacturing enterprise renewal

This book deals with a 'Participative Simulation environment for Intelligent Manufacturing' (PSIM). PSIM is a software environment for use in assembly operations and it is developed and pilot-demonstrated in five companies: Volvo (Sweden), Finland Post, Fiat (Italy), Yamatake (Japan), Ford (USA). PSIM is a combination of expertise in the areas...

Verschillende rollen bij het toepassen van participatieve ergonomie

Wanneer bekend is wie en wanneer betrokken moeten worden bij een ontwerpproces, kan dat proces veel beter vorm krijgen. Om daar meer helderheid over te krijgen is uit de literatuur over participatieve ergonomie de theoretisch ideale situatie beschreven. Daarnaast is bij een aantal Nederlandse en Japanse ergonomen gepeild hoe zij in de praktijk...

Toxicology of chemical mixtures: International perspective

This paper reviews major activities outside the United States on human health issues related to chemical mixtures. In Europe an international study group on combination effects has been formed and has started by defining synergism and antagonism. Successful research programs in Europe include the development and application of statistically...

Quantitative analysis of O-isopropyl methylphosphonic acid in serum samples of Japanese citizens allegedly exposed to sarin: Estimation of internal dosage

A convenient and rapid micro-anion exchange liquid chromatography (LC) tandem electrospray mass spectrometry (MS) procedure was developed for quantitative analysis in serum of O-isopropyl methylphosphonic acid (IMPA), the hydrolysis product of the nerve agent sarin. The mass spectrometric procedure involves negative or positive ion electrospray...