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Defective postreperfusion metabolic recovery directly associates with incident delayed graft function

Wijermars, L.G.M. (author), Schaapherder, A.F. (author), de Vries, D.K. (author), Verschuren, L. (author), Wüst, R.C.I. (author), Kostidis, S. (author), Mayboroda, O.A. (author), Prins, F. (author), Ringers, J. (author), Bierau, J. (author), Bakker, J.A. (author), Kooistra, T. (author), Lindeman, J.H.N. (author)

Delayed graft function (DGF) following kidney transplantation affects long-term graft function and survival and is considered a manifestation of ischemia reperfusion injury. Preclinical studies characterize metabolic defects resulting from mitochondrial damage as primary driver of ischemia reperfusion injury. In a comprehensive approach that...

article 2016

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Job Strain and the risk of stroke: An individual-participant data meta-analysis

Fransson, E.I. (author), Nyberg, S.T. (author), Heikkilä, K. (author), Alfredsson, L. (author), Bjorner, J.B. (author), Borritz, M. (author), Burr, H. (author), Dragano, N. (author), Geuskens, G.A. (author), Goldberg, M. (author), Hamer, M. (author), Hooftman, W.E. (author), Houtman, I.L. (author), Joensuu, M. (author), Jokela, M. (author), Knutsson, A. (author), Koskenvuo, M. (author), Koskinen, A. (author), Kumari, M. (author), Leineweber, C. (author), Lunau, T. (author), Madsen, I.E.H. (author), Hanson, L.L.M. (author), Nielsen, M.L. (author), Nordin, M. (author), Oksanen, T. (author), Pentti, J. (author), Pejtersen, J.H. (author), Rugulies, R. (author), Salo, P. (author), Shipley, M.J. (author), Steptoe, A. (author), Suominen, S.B. (author), Theorell, T. (author), Toppinen-Tanner, S. (author), Vahtera, J. (author), Virtanen, M. (author), Väänänen, A. (author), Westerholm, P.J.M. (author), Westerlund, H. (author), Zins, M. (author), Britton, A. (author), Brunner, E.J. (author), Singh-Manoux, A. (author), Batty, G.D. (author), Kivimäki, M. (author)

BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain. METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between...

article 2015

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Critical role of tissue kallikrein in vessel formation and maturation: Implications for therapeutic revascularization

Stone, O.A. (author), Richer, C. (author), Emanueli, C. (author), van Weel, V. (author), Quax, P.H.A. (author), Katare, R. (author), Kraenkel, N. (author), Campagnolo, P. (author), Barcelos, L.S. (author), Siragusa, M. (author), Sala-Newby, G.B. (author), Baldessari, D. (author), Mione, M. (author), Vincent, M.P. (author), Benest, A.V. (author), Al Haj Zen, A. (author), Gonzalez, J. (author), Bates, D.O. (author), Alhenc-Gelas, F. (author), Madeddu, P. (author), TNO Kwaliteit van Leven (author)

OBJECTIVE : Human Tissue Kallikrein (hKLK1) overexpression promotes an enduring neovascularization of ischemic tissue, yet the cellular mechanisms of hKLK1-induced arteriogenesis remain unknown. Furthermore, no previous study has compared the angiogenic potency of hKLK1, with its loss of function polymorphic variant, rs5515 (R53H), which...

article 2009

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Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis

TNO Kwaliteit van Leven (author), van Solingen, C. (author), Seghers, L. (author), Bijkerk, R. (author), Duijs, J.M.G.J. (author), Roeten, M.K. (author), Oeveren van - Rietdijk, A.M. (author), Baelde, H.J. (author), Monge, M. (author), Vos, J.B. (author), de Boer, H.C. (author), Quax, P.H.A. (author), Rabelink, T.J. (author), van Zonneveld, A.J. (author)

MicroRNAs are negative regulators of gene expression that play a key role in cell-type specific differentiation and modulation of cell function and have been proposed to be involved in neovascularization. Previously, using an extensive cloning and sequencing approach, we identified miR-126 to be specifically and highly expressed in human...

article 2009

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Vascular Growth in Ischemic Limbs: A Review of Mechanisms and Possible Therapeutic Stimulation

van Weel, V. (author), van Tongeren, R.B. (author), van Hinsbergh, V.W.M. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)

Stimulation of vascular growth to treat limb ischemia is promising, and early results obtained from uncontrolled clinical trials using angiogenic agents, e.g., vascular endothelial growth factor, led to high expectations. However, negative results from recent placebo-controlled trials warrant further research. Here, current insights into...

article 2008

document

Natural killer cells and CD4+ T-cells modulate collateral artery development

van Weel, V. (author), Toes, R.E.M. (author), Seghers, L. (author), Deckers, M.M.L. (author), de Vries, M.R. (author), Eilers, P.H. (author), Sipkens, J. (author), Schepers, A. (author), Eefting, D. (author), van Hinsbergh, V.W.M. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)

OBJECTIVE - The immune system is thought to play a crucial role in regulating collateral circulation (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease. Here, we studied the role of lymphocytes in a murine model of hindlimb ischemia. METHODS AND RESULTS - Lymphocytes, detected with markers for NK1.1,...

article 2007

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P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injury

Huls, M. (author), Kramers, C. (author), Levtchenko, E.N. (author), Wilmer, M.J.G. (author), Dijkman, H.B.P.M. (author), Kluijtmans, L.A.J. (author), van der Hoorn, J.W.A. (author), Russel, F.G.M. (author), Masereeuw, R. (author), TNO Kwaliteit van Leven (author)

The multidrug resistance gene 1 product, P-glycoprotein (P-gp), is expressed in several excretory organs, including the apical membrane of proximal tubules. After inducing acute renal failure, P-gp expression is upregulated and this might be a protective function by pumping out toxicants and harmful products of oxidative stress. We characterized...

article 2007

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CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms

Kraaijeveld, A.O. (author), de Jager, S.C.A. (author), de Jager, W.J. (author), Prakken, B.J. (author), McColl, S.R. (author), Haspels, I. (author), Putter, H. (author), van Berkel, T.J.C. (author), Nagelkerken, L. (author), Jukema, J.W. (author), Biessen, E.A.L. (author), TNO Kwaliteit van Leven (author)

BACKGROUND - Chemokines play an important role in atherogenesis and in ischemic injury and repair; however, prospective data on individual chemokines in unstable angina pectoris (UAP) are scarce. Therefore, we assessed chemokine patterns in a prospective cohort of patients with UAP. METHODS AND RESULTS - Plasma samples of 54 patients with...

article 2007

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Expression of vascular endothelial growth factor, stromal cell-derived factor-1, and CXCR4 in human limb muscle with acute and chronic ischemia

van Weel, V. (author), Seghers, L. (author), de Vries, M.R. (author), Kuiper, E.J. (author), Schlingemann, R.O. (author), Bajema, I.M. (author), Lindeman, J.H.N. (author), van Delis-Diemen, P.M. (author), van Hinsbergh, V.W.M. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)

OBJECTIVE - Vascular endothelial growth factor (VEGF)-induced stromal cell-derived factor-1 (SDF-1) has been implicated in angiogenesis in ischemic tissues by recruitment of CXCR4-positive bone marrow-derived circulating cells with paracrine functions in preclinical models. Here, evidence for this is provided in patients with peripheral artery...

article 2007

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The effects of the fibrin-derived peptide Bβ15-42 in acute and chronic rodent models of myocardial ischemia-reperfusion

Zacharowski, K. (author), Zacharowski, P.A. (author), Friedl, P. (author), Mastan, P. (author), Koch, A. (author), Boehm, O. (author), Rother, R.P. (author), Reingruber, S. (author), Henning, R. (author), Emeis, J.J. (author), Petzelbauer, P. (author), TNO Kwaliteit van Leven (author)

Many compounds have been shown to prevent reperfusion injury in various animal models, although to date, translation into clinic has revealed several obstacles. Therefore, the National Heart, Lung, and Blood Institute convened a working group to discuss reasons for such failure. As a result, the concept of adequately powered, blinded, randomized...

article 2007

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Plasma levels of apolipoprotein E and risk of stroke in old age

van Vliet, P. (author), Mooijaart, S.P. (author), de Craen, A.J.M. (author), Rensen, P.C.N. (author), van Heemst, D. (author), Westendorp, R.G.J. (author), TNO Kwaliteit van Leven (author)

Recently, high plasma apoE levels have been shown to be related to increased cardiovascular mortality, independent of APOE genotype. Here we studied the association of plasma apoE levels with risk of stroke. Within the Leiden 85-plus Study, a prospective population-based study of 561 subjects aged 85 years, we measured plasma apoE level and...

bookPart 2007

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Alcohol and ischaemic heart disease [7]

Beulens, J.W.J. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)

article 2006

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Hypercholesterolemia reduces collateral artery growth more dominantly than hyperglycemia or insulin resistance in mice

van Weel, V. (author), de Vries, M. (author), Voshol, P.J. (author), Verloop, R.E. (author), Eilers, P.H.C. (author), van Hinsbergh, V.W.M. (author), van Bockel, J.H. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)

OBJECTIVE - Collateral artery development (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease, may be deregulated by vascular risk factors, eg, diabetes or hypercholesterolemia. Here, we compared the effects of either disturbed glucose metabolism or disturbed lipid metabolism on arteriogenesis. METHODS...

article 2006

document

Tumor necrosis factor-α plays an important role in restenosis development

Monraats, P.S. (author), Pires, N.M.M. (author), Schepers, A. (author), Agema, W.R.P. (author), Boesten, L.S.M. (author), de Vries, M.R. (author), Zwinderman, A.H. (author), de Maat, M.P.M. (author), Doevendans, P.A.F.M. (author), de Winter, R.J. (author), Tio, R.A. (author), Waltenberger, J. (author), 't Hart, L.M. (author), Frants, R.R. (author), Quax, P.H.A. (author), van Vlijmen, B.J.M. (author), Havekes, L.M. (author), van der Laarse, A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)

Genetic factors appear to be important in the restenotic process after percutaneous coronary intervention (PCI), as well as in inflammation, a pivotal factor in restenosis. TNFα, a key regulator of inflammatory responses, may exert critical influence on the development of restenosis after PCI. The GENetic DEterminants of Restenosis (GENDER)...

article 2005

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Vascular endothelial growth factor overexpression in ischemic skeletal muscle enhances myoglobin expression in vivo

van Weel, V. (author), Deckers, M.M.L. (author), Grimbergen, J.M. (author), van Leuven, K.J.M. (author), Lardenoye, J.W.H.P. (author), Schlingemann, R.O. (author), van Nieuw Amerongen, G.P. (author), van Bockel, J.H. (author), van Hinsbergh, V.W.M. (author), Quax, P.H.A. (author), Gaubius Instituut TNO (author)

Therapeutic angiogenesis using vascular endothelial growth factor (VEGF) is considered a promising new therapy for patients with arterial obstructive disease. Clinical improvements observed consist of improved muscle function and regression of rest pain or angina. However, direct evidence for improved vascularization, as evaluated by angiography...

article 2004

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An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men

Agema, W.R.P. (author), de Maat, M.P.M. (author), Zwinderman, A.H. (author), Kastelein, J.J.P. (author), Rabelink, T.J. (author), van Boven, A.J. (author), Feskens, E.J.M. (author), Boer, J.M.A. (author), van der Wall, E.E. (author), Jukema, J.W. (author), Gaubius Instituut TNO (author)

In the present study, we sought to evaluate the role of three polymorphisms in the ecNOS (endothelial constitutive nitric oxide synthase) gene in relation to the existence, severity and progression of CAD (coronary artery disease), MI (myocardial infarction) and the occurrence of ischaemia in a predominantly Caucasian population. Patients with...

article 2004

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Evidence of the regulatory effect of Ginkgo biloba extract on skin blood flow and study of its effects on urinary metabolites in healthy humans

Boelsma, E. (author), Lamers, R.-J.A.N. (author), Hendriks, H.F.J. (author), van Nesselrooij, J.H.J. (author), Roza, L. (author), TNO Voeding (author)

Ginkgo biloba extract has been advocated for the improvement of blood circulation in circulatory disorders. This study investigated the effect of the Gingko biloba extract EGb 761 on skin blood flow in healthy volunteers and accompanying changes in urinary metabolites. Twenty-seven healthy middle-aged subjects participated in a randomized,...

article 2004

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Cardiovascular disease and mortality in statin-treated patients with familial hypercholesterolemia

Mohrschladt, M.F. (author), Westendorp, R.G.J. (author), Gevers Leuven, J.A. (author), Smelt, A.H.M. (author), Gaubius Instituut TNO (author)

Patients with familial hypercholesterolemia (FH) are at an increased risk of premature cardiovascular disease (CVD). The benefits of statin therapy are not well known since no placebo controlled studies have been performed in these patients. The aim of this study was to determine the CVD event and mortality risk in statin-treated patients with...

article 2004

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Influence of inhibition of nitric oxide synthesis on cardiac function in the newborn lamb after hypoxic-ischemic injury

Dorrepaal, C.A. (author), van Bel, F. (author), Steendijk, P. (author), Shadid, M. (author), van de Velde, E.T. (author), Baan, J. (author), TNO Preventie en Gezondheid (author)

The aim of the present study was to investigate the effect of immediate post-hypoxic-ischemic (HI) inhibition of nitric oxide synthesis by N(ω)- nitro-L-arginine (NLA) on cardiac function and reactive oxygen species production. Fifteen newborn lambs were subjected to severe HI. Upon resuscitation 5 received 10 mg NLA/kg, 4 40 mg NLA/kg and 6 a...

article 2000

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Dietary iron and risk of myocardial infarction in the Rotterdam Study

Klipstein-Grobusch, K. (author), Grobbee, D.E. (author), den Breeijen, J.H. (author), Boeing, H. (author), Hofman, A. (author), Witteman, J.C.M. (author)

Free iron has been implicated in lipid peroxidation and ischemic myocardial damage, and it has been suggested that iron is an independent risk factor for myocardial infarction. The authors investigated whether dietary iron is associated with an increased risk of fatal and nonfatal myocardial infarction in the Rotterdam Study, a community-based...

article 1999