Searched for: subject%3A%22Intraperitoneal%255C%2Bdrug%255C%2Badministration%22
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Korst, A.E.C. (author), Boven, E. (author), van der Sterre, M.L.T. (author), Fichtinger-Schepman, A.M.J. (author), van der Vijgh, W.J.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Amifostine (Ethyol, WR-2721) is in use in the clinic as a protector against platinum-induced toxicities. We have previously reported that amifostine induced a potentiation of the antitumour activity of carboplatin in human ovarian cancer xenografts. An influence of amifostine on the pharmacokinetics of carboplatin, resulting in higher platinum...
article 1998
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Schreuder, M.P. (author), Deen, C. (author), Boersma, W.J.A. (author), Pouwels, P.H. (author), Klis, F.M. (author), Gaubius Instituut TNO TNO Voeding (author)
The two major hydrophilic regions of the hepatitis B virus surface antigen (HBsAg) have been expressed in the outer mannoprotein layer of the cell wall of 'Bakers Yeast', Saccharomyces cerevisiae, by fusing them between the yeast invertase signal sequence and the yeast α-agglutinin carboxyterminal cell wall anchoring sequence. The fusion protein...
article 1996
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Dobber, R. (author), Tielemans, M. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
In the present study we investigated whether age-related changes in the composition and functional properties of murine CD4+ T cells are reflected in vivo by a changed humoral response to influenza vaccine in aged mice. After the primary immunization, the titers of influenza-specific IgM, IgG1, IgG2a, and IgG2b, but not of IgG3 and IgE, were...
article 1995
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Leenaars, P.P.A.M. (author), Hendriksen, C.F.M. (author), Koedam, M.A. (author), Claassen, I. (author), Claassen, E. (author), Gaubius Instituut TNO (author)
Four types of adjuvants were evaluated as alternatives to the use of Freund's complete adjuvant in mice. The adjuvants evaluated included a water-in-oil emulsion (Specol), a microorganism (Lactobacillus), preformed immune-stimulating complexes (ISCOM) containing rabies virus glycoprotein and a saponin, Quil A. The adjuvants and saline were...
article 1995
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van Raaij, J.A.G.M. (author), Frijters, C.M.G. (author), Wong Yen Kong, L. (author), van den Berg, K.J. (author), Notten, W.R.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
In the present study the effects of hexachlorobenzene (HCB) and the metabolite pentachlorophenol (PCP) were investigated with respect to uptake of thyroxine (T4) into cerebrospinal fluid (CSF) and brain structures of rats. [125I]T4 was taken up into CSF of control rats by a relatively slow process, reaching a steady state after about 3 h. Both...
article 1994
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van Raaij, J.A.G.M. (author), Kaptein, E. (author), Visser, T.J. (author), van den Berg, K.J. (author), Medisch Biologisch Laboratorium TNO (author)
Metabolism of thyroid hormones was investigated in WAG/MBL rats that had been exposed to hexachlorobenzene (HCB). Serum thyroxine (T4) levels were lowered by 35.5%, whereas triiodothyronine (T3) levels were not changed. Bile flow, as well as T4 excretion in bile were increased by HCB treatment. Analysis of bile by HPLC revealed a more than 3...
article 1993
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van den Berg, K.J. (author), Gramsbergen, J.B.P. (author), Medisch Biologisch Laboratorium TNO Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: calcium, 7440-70-2; kainic acid, 487-79-6; Biological Markers; Calcium, 7440-70-2; Glial Fibrillary Acidic Protein; Kainic Acid, 487-79-6; Neurotoxins
article 1993
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Emeis, J.J. (author), van den Hoogen, C.M. (author), Gaubius Laboratory IVVO-TNO, P.O. Box 430, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Pharmacological modulation of the in vivo induction of plasminogen activator inhibitor type-1 (PAI-1) synthesis was studied in rats using the induction of PAI-1 by endotoxin as a model system. Both the cyclooxygenase inhibitors acetylsalicylic acid and indomethacin enhanced PAI-1 induction. The combined cyclooxygenase-lipoxygenase inhibitor,...
article 1992
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van den Eertwegh, A.J.M. (author), Laman, J.D. (author), Schellekens, M.M. (author), Boersma, W.J.A. (author), Claassen, E. (author), Medisch Biologisch Laboratorium TNO (author)
In this study we demonstrate a hitherto undescribed phenomenon, namely that thymus-independent type-2 antigens (TI-2 Ag) localize in splenic follicles within 1 h after administration. The follicular localization of 2,4,6-trinitrophenyl (TNP)-Ficoll was not antibody mediated. In addition in case of high-dose administration we observed a...
article 1992
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Bosland, M.C. (author), Prinsen, M.K. (author), Dirksen, T.J.M. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
Carcinomas of the rat prostate induced by a single injection of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, after sequential treatment with cyproterone acetate and testosterone propionate, were evaluated as potential animal model for prostatic cancer. All ten carcinomas examined were located in the...
article 1990
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Prins Maurits Laboratorium TNO Medisch Biologisch Laboratorium TNO (author), Benschop, H.P. (author), Bijleveld, E.C. (author), de Jong, L.P.A. (author), van der Wiel, H.J. (author), van Helden, H.P.M. (author)
The toxicokinetics of the four stereoisomers of C(??)P(??)-soman were investigated in anesthetized, atropinized, and artificially ventilated rats at iv doses of 6 (495 ??g/kg) and 3 LD50. By integration of a thermodesorption/cold trap injector into our GLC analysis, the soman stereoisomers could be followed in rat blood down to a minimum...
article 1987
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Radiobiologisch Instituut TNO (author), Varekamp, A.E. (author), de Vries, A.J. (author), Hagenbeek, A. (author)
Interstitial pneumonitis (IP) is one of the major complications after allogeneic bone marrow transplantation (incidence: 30 to 50%, fatality rate: 50 to 60%). Cytomegalovirus is associated with 60% of the cases. When no infectious agent can be detected, it is classified as idiopathic IP (IIP). Factors related to IIP are: remission induction...
article 1986
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Medisch Biologisch Laboratorium TNO (author), Kulig, B.M. (author), Vanwersch, R.A.P. (author), Wolthuis, O.L. (author)
The effects of CNS-active drugs and neurotoxic agents on motor coordination in the rat were studied using a newly developed, automated technique. In this test, a tv/microprocessor-based system was utilized to detect and describe the movement and placement characteristics of one of the rat's hindpaws as the rat placed its paw from one rung to...
article 1985
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Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The effects of etiracetam, a structural analogue or piracetam, were investigated in rats on Y-maze discrimination acquisition, on open field behavior, on one-trial passive avoidance learning and on shuttlebox acquisition and extinction. The results indicate that this drug significantly enhances acquisition and may improve retention without...
article 1981
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Benschop, H.P. (author), van den Berg, G.R. (author), van Hooidonk, C. (author), de Jong, L.P.A. (author), Kientz, C.E. (author), Berends, F. (author), Kepner, L.A. (author), Meeter, E. (author), Visser, R.P.L.S. (author), Medisch Biologisch Laboratorium TNO (author)
Three new nonquaternary oximes have been evaluated with respect to their antidotal activities against organophosphate poisoning. The oximes 1,2,3-thiadiazole-5-carboxaldoxime (1, pKa = 7.6), 2-methyl-1,3,4-thiadiazole-5-carboxaldoxime (2, pKa = 8.4), and 3-methyl-1,2,4-thiadiazole-5-carboxaldoxime (3, pKa = 7.0) were prepared in yields of 56, 24...
article 1979
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Tanger, H.J. (author), Vanwersch, R.A.P. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
A method is described whereby open field behaviour of rats can be automatically registered using a TV camera, a video converter, an X-Y recorder and a papertape puncher. Use is made of the scanning properties of the TV camera to obtain the X and Y coordinates of the rat's position and to print this position on an X-Y recorder to obtain the...
article 1978
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Kepner, L.A. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The bisquaternary mono-oximes HS-6 and HI-6 may both be considered as potential therapeutic agents for soman intoxication. It has been found that HI-6 was superior to an equal dose of HS-6 in the treatment of soman intoxication in mice and rats. Not only did HI-6 protect against higher levels of soman, but also fewer 'delayed deaths' were seen...
article 1978
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Radiobiologisch Instituut TNO (author), Maat, B. (author)
Recent data on extrapulmonary colony formation after heparin administration are inconclusive. A systemic study of this topic was undertaken with 4 experimental tumour systems and 2 distinct periods of reduced clotting capacity in rats and mice. I.v. injection of various numbers of tumour cells into i.p. heparinized animals leads to: Significant...
article 1978
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Nickolson, V.J. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)
The effect of Piracetam on rat cerebral protein metabolism in vivo and in vitro was studied. It was found that the drug stimulates the uptake of labelled leucine by cerebral cortex slices, has no effect on the incorporation of leucine into cerebral protein, neither in slices nor in vivo, but inhibits the breakdown of newly formed protein in...
article 1976
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Radiobiologisch Instituut TNO (author), Sindram, P.J. (author), Snow, G.B. (author), van Putten, L.M. (author)
Chemicals/CAS: folinate calcium, 1492-18-8, 51057-63-7; folinic acid, 58-05-9, 68538-85-2; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; Leucovorin, 58-05-9; Methotrexate, 59-05-2
article 1974
Searched for: subject%3A%22Intraperitoneal%255C%2Bdrug%255C%2Badministration%22
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