Searched for: subject%3A%22Intoxication%22
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Medisch Biologisch Laboratorium TNO (author), Muijser, H. (author), Hoogendijk, E.M.G. (author), Hooisma, J. (author), Twisk, D.A.M. (author)
In a group of workers exposed to high levels of lead during five months nerve conduction velocity parameters were evaluated at the termination of exposure, and also three and fifteen months later. At the termination of exposure the mean blood lead level was 4.0 ??mol/l, and motor conduction velocities in the median and the ulnar nerves were...
article 1987
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van Graft, M. (author), Spit, B.J. (author), Immel, H.R. (author), Feron, V.J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
In a one-year serial sacrifice study 10 mg glass fibres (length, 95% ?? 20 ??m, 89% ?? 12 ??m, 58% ?? 5 ??m and 25% ?? 2 ??m; diameter, 88% ?? 1.0 ??m, 60% ?? 0.5 ??m and 31% ??0.25 ??m) suspended in 0.2 ml saline solution were administered to Syrian golden hamsters by a single intratracheal instillation to determine the clearance of the glass...
article 1986
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Feron, V.J. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
Despite increasing standardisation and international harmonisation of the long-term carcinogenicity study in rodents there are still areas of controversy such as high-dose selection, duration of the test period, combining or not combining the chronic toxicity and the carcinogenicity study, the use of historical control data, conditions for...
article 1986
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Appelman, L.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The toxicity data of 66 compounds adequately tested in the rat (as 'prime animal species') and in the dog (as 'second animal species') were studied to find out for how many of these compounds the study in dogs led to a lower 'no-toxic-effect level' (NTEL) than that found in the rat. From a quantitative point of view such information would...
article 1986
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Til, H.P. (author), Feron, V.J. (author), Immel, H.R. (author), Vogel, W.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
article 1986
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Appelman, L.M. (author), Woutersen, R.A. (author), Feron, V.J. (author), Hooftman, R.N. (author), Notten, W.R.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The effects of exposure pattern on the toxicity of acetaldehyde vapour were investigated in 4-week inhalation studies. Male rats were exposed to 500 or 150 and 110 ppm for 6 h per day/5 days per week. One group of animals was exposed without interruption, the exposure of a second group was interrupted for 1.5 h between the first and second 3-h...
article 1986
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Radiobiologisch Instituut TNO (author), Varekamp, A.E. (author), de Vries, A.J. (author), Hagenbeek, A. (author)
Interstitial pneumonitis (IP) is one of the major complications after allogeneic bone marrow transplantation (incidence: 30 to 50%, fatality rate: 50 to 60%). Cytomegalovirus is associated with 60% of the cases. When no infectious agent can be detected, it is classified as idiopathic IP (IIP). Factors related to IIP are: remission induction...
article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), Woutersen, R.A. (author), Appelman, L.M. (author), van Garderen-Hoetmer, A. (author), Feron, V.J. (author)
Male and female Wistar rats were exposed to acetaldehyde vapour at nominal concentrations 0, 750, 1500 or 3000/1000 ppm during 6 h/day, 5 days/week for up to 28 months. Major compound-related effects included increased mortality, growth retardation, nasal tumours, and non-neoplastic nasal changes in each of the test groups. The treatment-related...
article 1986
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Centraal Instituut voor Voedingsonderzoek TNO (author), ten Berge, W.F. (author), Zwart, A. (author), Appelman, L.M. (author)
This report presents the re-evaluation of the raw data of previously published acute inhalation toxicity studies of some volatile industrial chemicals. In these studies both concentration and exposure time were varied. The raw data were obtained from an extensive literature search and were subjected to probit analysis. The results show that the...
article 1986
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Janssen, P.J.M. (author), Bosland, M.C. (author), van Hees, J.P. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)
The effects of feeding inorganic tin on the gastrointestinal tract were examined in rats. Three groups of male weanling Wistar rats were fed a diet to which 0, 250, or 500 ppm Sn2+ had been added as SnCl2. A fourth group was subjected to feed restriction by pair feeding with the 500-ppm group. Comparison of the data from the tin-fed groups with...
article 1985
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Medisch Biologisch Laboratorium TNO (author), Kulig, B.M. (author), Vanwersch, R.A.P. (author), Wolthuis, O.L. (author)
The effects of CNS-active drugs and neurotoxic agents on motor coordination in the rat were studied using a newly developed, automated technique. In this test, a tv/microprocessor-based system was utilized to detect and describe the movement and placement characteristics of one of the rat's hindpaws as the rat placed its paw from one rung to...
article 1985
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Instituut CIVO-Toxicologie en Voeding TNO (author), Willems, M.I. (author), de Raat, W.K. (author)
article 1985
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de Vos, R.H. (author), van Dokkum, W. (author), Olthof, P.D.A. (author), Quirijns, J.K. (author), Muys, T. (author), van der Poll, J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Over a period of 2 yr 126 different food items of a market basket of 16-18 yr old males were purchased every 2 months. The foodstuffs were prepared as for eating, and were combined in 12 commodity groups. Twelves samples of each food group were homogenized and analysed for 78 different chemicals, including pesticides, PCBs, bromine, heavy metals...
article 1984
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Prins Maurits Laboratorium TNO Medisch Biologisch Laboratorium TNO (author), Benschop, H.P. (author), Konings, C.A.G. (author), van Genderen, J. (author), de Jong, L.P.A. (author)
The four stereoisomers of the nerve agent pinacolyl methylphosphonofluoridate (soman), designated as C(+)P(+), C(+)P(-), C(-)P(+), and C(-)P(-), have different toxicologic properties due to stereospecific interactions in living organisms. We report the isolation of these stereoisomers with more than 99% optical purity. This result was realized...
article 1984
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Ko√ęter, H.B.W.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Toxicity data of 37 compounds tested in both a subchronic study and one or more studies focused on reproduction were evaluated to obtain information on the significance of fertility and reproduction parameters in setting no-effect levels (NEL). It appeared that a) the test system aimed at reproduction and development was more sensitive than the...
article 1983
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Hooisma, J. (author), Medisch Biologisch Laboratorium TNO (author)
Application of tissue culture in neurotoxicology may serve two purposes. First, they may be used to unravel the mechanism of action of neurotoxic compounds and secondly, they may be used for the screening of neurotoxic agents. Studies belonging to the first group can be subdivided into those aiming at the replication of neurotoxic processes in...
article 1982
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Appelman, L.M. (author), ten Berge, W.F. (author), Reuzel, P.G.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The acute inhalation toxicity of ammonia was examined in rats using various exposure concentrations and exposure periods. Groups of male and female rats were exposed to dynamic atmospheres containing different concentrations of ammonia for 10, 20, 40 or 60 min. The aim of the study was to establish the relationship between exposure concentration...
article 1982
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Centraal Instituut voor Voedingsonderzoek TNO (author), Appelman, L.M. (author), Woutersen, R.A. (author), Feron, V.J. (author)
The 4-h LC50 of acetaldehyde in rats was determined and found to be 13,300 ppm (24.0 g/m3 air). In a 4-week study groups of 10 male and 10 female rats were exposed to 0, 400, 1000, 2200 or 5000 ppm acetaldehyde for 6 h/day, 5 days/week. Treatment-related changes observed at the 5000 ppm level included dyspnoea and excitation during the first 30...
article 1982
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Hooisma, J. (author), Dam, E.W. (author), Medisch Biologisch Laboratorium TNO (author)
Chemicals/CAS: 2 hexanone, 591-78-6; acetonylacetone, 110-13-4; hexane, 110-54-3
article 1981
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Appelman, L.M. (author), Hendriksen, C.F.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The subacute inhalation toxicity of ??-ethylacrolein was examined in rats by repeated exposure of 4 groups of 10 males and 10 females each to ??-ethylacrolein vapour at concentrations of 0, 2.0, 9.8 or 48.4 ppm, respectively, (6 h/day, 5 days/week) for a period of 13 weeks. The effects at 48.4 ppm were found to include growth retardation, focal...
article 1981
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