Searched for: subject:"Intestines"
(1 - 20 of 205)

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Donkers, J.M. (author), Eslami Amirabadi, H. (author), van de Steeg, E. (author)
Over the past decade, microfluidic intestine-on-a-chip models have been emerging as a novel platform to study intestinal function in health and disease. These microphysiological systems surpass conventional in vitro intestinal model systems, as they add microenvironmental context in the form of mechanical cues or by the incorporation of multiple...
article 2021
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Rahman, S. (author), Davids, M. (author), van Hamersveld, P.H.P. (author), Welting, O. (author), Rahaoui, H. (author), Schuren, F. (author), Meijer, S.L. (author), van den Wijngaard, R.M. (author), Hakvoort, T.B.M. (author), de Jonge, W.J. (author), Heinsbroek, S.E.M. (author)
β-glucan consumption is known for its beneficial health effects, but the mode of action is unclear. While humans and mice lack the required enzymes to digest β-glucans, certain intestinal microbes can digest β-glucans, triggering gut microbial changes. Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive...
article 2021
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Smits, M. (author), Nooijen, I. (author), Redegeld, F. (author), de Jong, A. (author), Le, T.M. (author), Knulst, A. (author), Houben, G.F. (author), Verhoeckc, K.C.M. (author)
Scope: No accepted and validated methods are currently available which can accurately predict protein allergenicity. In this study, the role of digestion and transport on protein allergenicity is investigated. Methods and results: Peanut allergens (Ara h 1, 2, 3, and 6) and a milk allergen (β-lactoglobulin) are transported across pig intestinal...
article 2021
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Pieterman, E.J. (author), Princen, H.M.G. (author), Jarke, A. (author), Nilsson, R. (author), Cavallin, A. (author), Bergenholm, L. (author), Henricsson, M. (author), Gopaul, V.S. (author), Agrawal, R. (author), Nissen, S.E. (author), Hurt-Camejo, E. (author)
We investigated the effects of chronic oral administration of mineral oil, versus corn oil as control, on intestinal permeability, inflammatory markers, and plasma lipids in APOE*3-Leiden.CETP mice. Mice received mineral oil or corn oil 15 or 30 μL/mouse/day for 16 weeks (15 mice/group). Intestinal permeability was increased with mineral versus...
article 2021
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Griffiths, J.C. (author), de Vries, J. (author), McBurney, M.I. (author), Wopereis, S. (author), Serttas, S. (author), Marsman, D.S. (author)
Commonly, it is the end of life when our health is deteriorating, that many will make drastic lifestyle changes to improve their quality of life. However, it is increasingly recognized that bringing good health-promoting behaviors into practice as early in life as possible has the most significant impact across the maximal healthspan. The WHO...
article 2020
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Stevens, L.J. (author), Donkers, J.M. (author), Dubbel, J. (author), Vaes, W.H.J. (author), van de Steeg, E. (author), Knibbe, C.A.J. (author), Alwayn, I.P.J. (author), van de Steeg, E. (author)
To predict the absorption, distribution, metabolism and excretion (ADME) profile of candidate drugs a variety of preclinical models can be applied. The ADME and toxicological behavior of newly developed drugs are often investigated prior to assessment in humans, which is associated with long time-lines and high costs. Therefore, good predictions...
article 2020
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Verhoeckx, K. (author), Bogh, K.L. (author), Dupont, D. (author), Egger, L. (author), Gadermaier, G. (author), Larre, C. (author), Mackie, A. (author), Menard, O. (author), Adel-Patient, K. (author), Picariello, G. (author), Portmann, R. (author), Smit, J. (author), Turner, P. (author), Untersmayr, E. (author), Epstein, M.M. (author)
The current allergenicity assessment of novel proteins is based on the EFSA GMO guidance. Recently, EFSA launched a new guidance document on allergenicity assessment of GM plants (2017). This document describes, amongst other topics, the new scientific and regulatory developments on in vitro protein digestibility tests. The EFSA GMO Panel stated...
article 2019
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Stevens, L.J. (author), van Lipzig, M.M.H. (author), Erpelinck, S.L.A. (author), Pronk, A. (author), van Gorp, J. (author), Wortelboer, H.M. (author), van de Steeg, E. (author)
A majority of the preclinical intestinal screening models do not properly reflect the complex physiology of the human intestinal tract, resulting in low translational value to the clinical situation. The often used cell lines such as Caco-2 or HT-29 are not well suited to investigate the different processes that predict oral bioavailability in...
article 2019
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Kubbinga, M. (author), Augustijns, P. (author), Garcia, M.A. (author), Heinen, C. (author), Wortelboer, H.M. (author), Verwei, M. (author), Langguth, P. (author)
Chitosan is object of pharmaceutical research as a candidate permeability enhancer. However, chitosan was recently shown to reduce the oral bioavailability of acyclovir in humans. The effect of chitosan on two processes determining the oral bioavailability of acyclovir, bioaccessibility and intestinal absorption, was now investigated. Acyclovir...
article 2019
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Bellmann, S. (author), Krishnan, S. (author), de Graaf, A. (author), de Ligt, R.A. (author), Pasman, W.J. (author), Minekus, M. (author), Havenaar, R. (author)
The expected increase of global obesity prevalence makes it necessary to have information about the effects of meal intakes on the feeling of appetite. Because human clinical studies are time and cost intensive, there is a need for a reliable alternative. The aim of this study was to develop and evaluate an in vitro-in silico technology to...
article 2019
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Erpelinck, E. (author), Meijers, T. (author), Ariga, K. (author)
The TNO InTESTine™ system is developed to study the absorption and translocation of pharmaceutical, biological and nutritional compounds across the intestinal wall in a physiologically relevant model. In this medium-throughput system, fresh ex vivo intestinal tissue from human or animal origin is mounted into a two compartment model with an...
other 2019
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Erpelinck, S.L.A. (author), Meijers, T. (author), Ariga, K. (author)
other 2019
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Amirabadi, H. Eslami (author), Wierenga, E. (author), Stevens, L.J. (author), Donkers, J. (author), Donkers, T. (author), Ingenhut, B.L.J. (author), Usta, B. (author), Pieters, L. (author), Gröllers, M. (author), Nooijen, I.H.G. (author), Erpelinck, S.L.A. (author), Schuren, F. (author), Masereeuw, R. (author), van de Steeg, E. (author)
The majority of screening and predictive models do not reflect the physiology of the human intestinal tract since they show major limitations to include the processes that determine the oral bioavailability1,2. A major drawback of current intestinal models is the use of single cell lines and the static environment, which is in contrast with the...
public lecture 2019
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Atukunda, P. (author), Muhoozi, G.K.M. (author), van den Broek, T.J. (author), Kort, R. (author), Diep, L.M. (author), Kaaya, A.N. (author), Iversen, P.O. (author), Westerberg, A.C. (author)
Background Undernutrition impairs child development outcomes and growth. In this follow-up study of an open cluster-randomized intervention trial we examined the effects of an education package delivered to mothers in rural Uganda on their children's development, growth and gut microbiota at 36 months of age. Methods The parental trial included...
article 2019
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Fieten, K.B. (author), Totté, J.E.E. (author), Levin, E. (author), Reyman, M. (author), Meijer, Y. (author), Schuren, F.H.J. (author), Pasmans, S.G.M.A. (author), Pasmans, S.G.M.A. (author)
Background: Exposure to microbes may be important in the development of atopic disease. Atopic diseases have been associated with specific characteristics of the intestinal microbiome. The link between intestinal microbiota and food allergy has rarely been studied, and the gold standard for diagnosing food allergy (double-blind placebo...
article 2018
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Botschuijver, S. (author), Welting, O. (author), Levin, E. (author), Maria-Ferreira, D. (author), Koch, E. (author), Montijn, R.C. (author), Seppen, J. (author), Hakvoort, T.B.M. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), van den Wijngaard, R.M. (author)
Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder associated with altered gastrointestinal microflora and increased nociception to colonic distension. This visceral hypersensitivity can be reversed in our rat maternal separation model by fungicides. Menthacarin® is a proprietary combination of essential oils from...
article 2018
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Bogerd, C.P. (author), Velt, K.B. (author), Annaheim, S. (author), Bongers, C.C.W.G. (author), Eijsvogels, T.M.H. (author), Daanen, H.A.M. (author)
OBJECTIVE: The discomfort caused by rectal probes and esophageal probes for the estimation of body core temperature has triggered the development of gastrointestinal (GI) capsules that are easily accepted by athletes and workers due to their non-invasive characteristics. We compare two new GI capsule devices with rectal temperature during cycle...
article 2018
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Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)
Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...
article 2017
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Botschuijver, S. (author), Roeselers, G. (author), Levin, E. (author), Jonkers, D.M. (author), Welting, O. (author), Heinsbroek, S.E.M. (author), de Weerd, H.H. (author), Boekhout, T. (author), Fornai, M. (author), Masclee, A.A. (author), Schuren, F.H.J. (author), de Jonge, W.J. (author), Seppen, J. (author), van den Wijngaard, R.M. (author)
Background & Aims Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in the activation of nociceptive sensory pathways, but there have been few studies of the role of the mycobiome (the fungal microbiome) in the development of IBS. We analyzed intestinal mycobiomes of patients with...
article 2017
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Aguirre, M. (author), Venema, K. (author)
There is an elevated incidence of cases of obesity worldwide. Therefore, the development of strategies to tackle this condition is of vital importance. This review focuses on the necessity of optimising in vitro systems to model human colonic fermentation in obese subjects. This may allow to increase the resolution and the physiological...
article 2017
Searched for: subject:"Intestines"
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