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Spit, B.J. (author), Bretschneider, F. (author), Hendriksen, E.G.J. (author), Kuper, C.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The distribution of nerve fibres in the mucosa of the nasal septum of the rat was investigated by means of transmission electron microscopy on transverse and tangential ultrathin sections. Near the basement membrane of respiratory and squamous epithelium, a rather dense network of unmyelinated nerve fibres occurs. Some fibres in the respiratory...article 1993
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de Geus, B. (author), Hogenesch, H. (author), de Heer, E. (author), Bruijn, J.A. (author), van den Enden, M. (author), Rozing, J. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)This study was performed to characterize the intestinal lesions in chronic graft-versus-host disease (GVHD) in mice and to determine a possible role of intestinal intraepithelial lymphocytes (iIEL) in the development of these lesions. Chronic GVHD was induced by transfer of DBA/2 lymphocytes into non-irradiated (C57BL/10 x DBA/2)F1 (BDF1)...article 1993
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van Weerden, E.J. (author), Huisman, J. (author)In a study with twelve pigs of 60-70 kg live weight provided with a re-entrant cannula at the end of the ileum, and twelve intact, non-cannulated pigs, the fate of dietary doses of 100 and 200 g isomalt/kg during gastrointestinal passage was examined. From sugar analyses in ileal chyme it was calculated that 0.43 and 0.30 of the isomalt consumed...article 1993
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Centraal Instituut voor Voedingsonderzoek TNO (author), van Weerden, E.J. (author), Huisman, J. (author)In a study with ten pigs of 60-70 kg live weight, provided with a re-entrant cannula at the end of the ileum, and sixteen intact, non-cannulated pigs, the digestion and absorption of a dietary dose of 100 g isomalt/kg, and isomalt given between the meals as a 'sweet' on the basis of 50 and 100 g/kg feed consumption, were examined. In all three...article 1993
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Gezondheidsorganisatie TNO Instituut voor verouderings- en vaatziekten onderzoek TNO (author), HogenEsch, H. (author), Niewold, T.A. (author), Higuchi, K. (author), Tooten, P.C.J. (author), Gruys, E. (author), Radl, J. (author)The light microscopic and immunohistochemical features of a novel localized senile amyloidosis in the gastrointestinal tract of C57BL/Ka mice are described. Senile gastrointestinal amyloidosis was predominantly found in the lamina propria of the ileum, cecum and stomach and infrequently in other segments of the gastrointestinal tract. The Congo...article 1993
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Instituut voor Voedingsmiddelentechnologie TNO (author), Wortelboer, H.M. (author), de Kruif, C.A. (author), van Iersel, A.A.J. (author), Noordhoek, J. (author), Blaauboer, B.J. (author), van Bladeren, P.J. (author), Falke, H.E. (author)Male Wistar rats were given semi-synthetic diets supplemented with 0, 2.5, 5 and 20% cooked Brussels sprouts for 2, 7, 14 or 28 days. The effects on several cytochrome P-450 enzymes and phase II enzymes (glutathione S-transferase (GST), glucuronyl transferases 1 and 2 (GT1 and GT2) and DT-diaphorase (DTD)) in the liver and small intestinal...article 1992
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Centraal Instituut voor Voedingsonderzoek TNO (author), Huisman, J. (author), Heinz, T. (author), van der Poel, A.F.B. (author), van Leeuwen, P. (author), Souffrant, W.B. (author), Verstegen, M.W.A. (author)The faecal and ileal true protein digestibilities of the raw pea (Pisum sativum) varieties finale and frijaune and the ileal true protein digestibility of steam-processed common beans (Phaseolus vulgaris) were measured in piglets using the 15N-dilution technique. The faecal true protein digestibility of both pea varieties was about 97. The ileal...article 1992
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Instituut CIVO-Toxicologie en Voeding TNO (author), Groten, J.P. (author), Luten, J.B. (author), van Bladeren, P.J. (author)It has been shown that addition of extra calcium/phosphorus (Ca/P), zinc (Zn) and iron (Fe2+) to the diet results in a significant protection against cadmium (Cd) accumulation and toxicity in rats fed inorganic Cd salt. However, it is not clear whether the presence of these mineral supplements in the diet also protects against the Cd uptake from...article 1992
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Instituut voor Experimentele Gerontologie TNO Institute of Ageing and Vascular Research TNO (author), Dobber, R. (author), Hertogh-Huijbregts, A. (author), Rozing, J. (author), Bottomly, K. (author), Nagelkerken, L. (author)It is well known that immune reactivity declines with age. Recently, we demonstrated that the age-related decrease in IL-2 production by CD4+ T cells was accompanied by an increased production of IL-4 and interferon-gamma (IFN-gamma). This age-related shift in the profile of lymphokine production was related to phenotypic changes within the CD4+...article 1992
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Instituut voor Verouderings- en Vaatziekten Onderzoek TNO Gezondheidsorganisatie TNO (author), Geus, B.de (author), HogenEsch, H. (author), Kubo, R.T. (author), Rozing, J. (author)Murine intestinal intraepithelial lymphocytes (ilEL) represent a heterogeneous population of cells which contains both TCRαβ+ and TCRγδ+ cells. In contrast to the TCRαβ+ cell population in peripheral lymphoid organs, the TCRαβ+ ilEL contain high numbers of Thy-1-cells. This negativity of ilEL for Thy-1, a glycosylphosphatidyl inositol (GPI)...article 1992
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Centraal Instituut voor Voedingsonderzoek TNO (author), Schutte, J.B. (author), Jong, J.de (author), Polziehn, R. (author), Verstegen, M.W.A. (author)Hemicellulose consists primarily of pentose sugars, joined together in a polysaccharide chain with D-xylose as the most abundant component. Ileal digestibility and urinary excretion of D-xylose and associated effects of this pentose sugar on ileal and faecal digestibility of dry matter (DM), organic matter (OM), gross energy (GE) and nitrogen...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), Groten, J.P. (author), Sinkeldam, E.J. (author), Luten, J.B. (author), van Bladeren, P.J. (author)The distribution of cadmium was examined in rats fed diets containing either cadmium-metallothionein (CdMt) or cadmium chloride (CdCl2) for 4 weeks. The test diets contained 3, 10, or 30 mg Cd/kg diet (3, 10, or 30 ppm) as CdMt or 30 mg Cd/kg diet (30 ppm) as CdCl2. A second study was performed to establish the Cd content in liver and kidneys...article 1991
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Instituut CIVO-Toxicologie en Voeding TNO (author), van Vliet, T. (author), van Schaik, F. (author), van Schoonhoven, J. (author), Schrijver, J. (author)A method, using two different systems, is described for the high-performance liquid chromatographic analysis of retinol, retinal, retinoic acid, retinyl acetate, retinyl palmitate, α-, β- and γ-carotene, β-apo-6'-β-apo-8'-, β-apo-10'- and β-apo-12'-carotenal, ethyl β-apo-8'-carotenoate, α-tocopherol and α-tocopheryl acetate. The first system...article 1991
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Schutte, J.B. (author), Instituut voor Landbouwkundig Onderzoek en Biochemische Produkten TNO (author)An experiment was conducted to examine the effects of graded levels (2.5, 5.0, 7.5, 10.0, and 15.0%) of dietary D-xylose or L-arabinose on chick performance. As reference, D-glucose was included in the experiment. A second experiment was performed to determine the AMEn of D-xylose and L-arabinose. Results of Experiment 1 showed a significant...article 1990
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Hekman, P. (author), Rietveld, E.C. (author), Instituut voor Landbouwkundig Onderzoek en Biochemische Produkten TNO (author)Chyme concentrations and total recoveries of furazolidone (5 mg/kg body-weight) were determined by a HPLC-method, after oral administration of two different furazolidone formulations to piglets (n = 6) and pre-ruminant calves (n = 8), provided with an ileal re-entrant canula. Additional blood samples were taken from the calves to measure the...article 1988
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- Til, H.P. (author), Feron, V.J. (author), Immel, H.R. (author), Vogel, W.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author) article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), van Dokkum, W. (author), Wesstra, A. (author), Luyken, R. (author), Hermus, R.J.J. (author)Twelve young men were given for periods of 20 d, each of three mixed diets, namely a low-protein (LP) diet (9% total energy as protein, 67% of animal origin), a high-animal-protein (HA) diet (16% total energy as protein, 67% of animal origin) and a high-vegetable-protein (HV) diet (16% total energy as protein, 67% of vegetable origin). Retention...article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), Kroes, R. (author), Beems, R.B. (author), Bosland, M.C. (author), Bunnik, G.S.J. (author), Sinkeldam, E.J. (author)Dietary factors are now considered to be among the most important environmental risk determinations for cancer. In addition to epidemiological studies, experimental animal studies are an important tool to investigate dietary modulation in carcinogenesis. Results of recent experimental studies on the effect of some nutrients indicate that vitamin...conference paper 1986
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Janssen, P.J.M. (author), Bosland, M.C. (author), van Hees, J.P. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)The effects of feeding inorganic tin on the gastrointestinal tract were examined in rats. Three groups of male weanling Wistar rats were fed a diet to which 0, 250, or 500 ppm Sn2+ had been added as SnCl2. A fourth group was subjected to feed restriction by pair feeding with the 500-ppm group. Comparison of the data from the tin-fed groups with...article 1985
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Instituut CIVO-Toxicologie en voeding TNO (author), van Dokkum, W. (author), de Boer, B.C.J. (author), van Faassen, A. (author), Pikaar, N.A. (author), Hermus, R.J.J. (author)We suggest that a lower faecal pH may be correlated with a lower mortality of large-bowel cancer and that faecal pH should always be considered in epidemiological studies on the role of diet in colon carcinogenesis.article 1983