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Nolte-'t Hoen, E.N.M. (author), Boot, E.P.J. (author), Wagenaar-Hilbers, J.P.A. (author), van Bilsen, J.H.M. (author), Arkesteijn, G.J.A. (author), Storm, G. (author), Everse, L.A. (author), van Eden, W. (author), Wauben, M.H.M. (author), TNO Kwaliteit van Leven (author)Major problems in the analysis of CD4+ effector cell and regulatory T cell (Treg) populations in an activated immune system are caused by the facts that both cell types can express CD25 and that the discriminatory marker forkhead box p3 can only be analyzed in nonviable (permeabilized) cells. Here, we show that CD134 (OX40) can be used as a...article 2008
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van Wijk, F. (author), Wehrens, E.J.M. (author), Nierkens, S. (author), Boon, L. (author), Kasran, A. (author), Pieters, R. (author), Knippels, L.M.J. (author), TNO Kwaliteit van Leven (author)Background: Naturally occurring CD4+CD25+ regulatory T cells (Tregs) play a critical role in the maintenance of self-tolerance and it has been suggested that these Tregs may also be involved in preventing allergic disease. Objective: The precise role of CD4+CD25+ T cells in the regulation of allergic responses to mucosal antigens remains to be...article 2007