Continuous Security Testing: a case study on integrating dynamic security testing tools in CI/CD pipelines

Continuous Integration (CI) and Continuous Delivery (CD) have become a well-known practice in DevOps to ensure fast delivery of new features. This is achieved by automatically testing and releasing new software versions, e.g. multiple times per day. However, classical security management techniques cannot keep up with this quick Software...

The Tropomi instrument: Last steps towards final integration and testing

The Tropospheric Monitoring Instrument TROPOMI is ready for system level verification. All sub-units have been integrated and tested and final integration at Dutch Space in Leiden has been completed. The instrument will be subjected to a testing and calibration program and is expected to be ready for delivery to the spacecraft early 2015. Using...

The ChemScreen project to design a pragmatic alternative approachto predict reproductive toxicity of chemicals

There is a great need for rapid testing strategies for reproductive toxicity testing, avoiding animal use.The EU Framework program 7 project ChemScreen aimed to fill this gap in a pragmatic manner prefer-ably using validated existing tools and place them in an innovative alternative testing strategy. In ourapproach we combined knowledge on...

Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs

To improve the predictability of the zebrafish embryotoxicity test (ZET) for developmental (neuro)toxicity screening, we used a multiple-endpoints strategy, including morphology, motor activity (MA), histopathology and kinetics. The model compounds used were antiepileptic drugs (AEDs): valproic acid (VPA), carbamazepine (CBZ), ethosuximide (ETH)...

The OSIRIS Weight of Evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS)

In the FP6 European project OSIRIS, Integrated Testing Strategies (ITSs) for relevant toxicological endpoints were developed to avoid new animal testing and thus to reduce time and costs. The present paper describes the development of an ITS for repeated-dose toxicity called RepDose ITS which evaluates the conditions under which in vivo non...

The OSIRIS Weight of Evidence approach: ITS for skin sensitisation

Within the EU FP6 project OSIRIS approaches to Integrated Testing Strategies (ITSs) were developed, with the aim to facilitate the use of non-test and non-animal testing information in regulatory risk assessment of chemicals. This paper describes an analytical Weight-of-Evidence (WoE) approach to an ITS for the endpoint of skin sensitisation. It...

OSIRIS, a quest for proof of principle for integrated testing strategies of chemicals for four human health endpoints

Chemical substances policies in Europe are aiming towards chemical safety and at the same time a reduction in animal testing. These goals are alleged to be reachable by mining as many relevant data as possible, evaluate these data with regard to validity, reliability and relevance, and use of these data in so-called Integrated Testing Strategies...

Respiratory sensitization: Advances in assessing the risk of respiratory inflammation and irritation

Respiratory sensitization provides a case study for a new approach to chemical safety evaluation, as the prevalence of respiratory sensitization has increased considerably over the last decades, but animal and/or human experimental/predictive models are not currently available. Therefore, the goal of a working group was to design a road map to...

Testing and evaluation of off-gas filters for bioreactors by a new aerosol challenge test method (TBAC)

A TNO bacterial aerosol challenge (TBAC) filter test rig was developed for direct assessment of the effectiveness of bioreactor off gas filters as an alternative to routinely applied indirect wet integrity testing (IT). This TBAC test rig is based on bacterial aerosol challenging with Pseudomouas diminuta and dual monitoring by laser particle...