Searched for: subject:"Innovation"
(1 - 20 of 4,470)

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Schlunk, F. (author), Fisher, P. (author), Princen, H.M.G. (author), Rex, A. (author), Prinz, V. (author), Foddis, M. (author), Lütjohann, D. (author), Laufs, U. (author), Endres, M. (author)
Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PSCK9) neutralizing antibodies effectively lower plasma cholesterol levels and decrease cardiovascular events but also raised some concern that cognitive function could worsen as a side effect. Here, we performed experiments in mice to characterize the effect of anti-PCSK9 antibodies...
article 2021
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de Amorim Soares, G. (author), Carolus, J. (author), Daenen, M. (author), Masolin, A. (author), Birrenbach, T. (author), Gerber, A. (author), Wrigley, A. (author), Henzel, J. (author), Roosen, D. (author), Meuris, M. (author), Theelen, M.J. (author)
A round robin test was carried out in four PV laboratories to compare accelerated lifetime testing. Twenty commercial non-packaged CIGS solar cells of similar performance were spread and exposed to damp heat con-ditions (85 ◦C and 85% RH) for approximately 500 h. Their JV performance was monitored during the damp heat exposure. After the test,...
article 2021
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Caron, J.F. (author), Bäumer, S.M.B. (author)
The aberrations of reflective optical systems with one plane of symmetry are investigated in the most general case, with freeform surfaces and possibly different locations of the tangential and sagittal object and image. In this first paper in a series of two, we establish generalized ray-tracing equations including transverse aberrations up to...
article 2021
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Caron, J.F. (author), Bäumer, S.M.B. (author)
The aberrations of reflective optical systems with planar symmetry are investigated in the most general case, with freeform surfaces and possibly different locations of the tangential and sagittal object and image. In this second and last paper, closed-form expressions are derived for the aberrations created by an individual mirror. We study two...
article 2021
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Schenk, D. (author)
Over een aantal jaar moet op bijna 3 km hoogte, op een bergtop in Chili, ’s werelds grootste telescoop verrijzen. Deze Extremely Large Telescope (ELT) wordt gebouwd door de Europese Zuidelijke Sterrenwacht (ESO). De onderdelen worden momenteel op allerlei plekken ter wereld in elkaar gesleuteld, waaronder in Nederland. Zo zal TNO samen met het...
article 2021
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Smirnov, Y. (author), Schmengler, L. (author), Kuik, R. (author), Repecaud, P.A. (author), Najafi, M. (author), Zhang, D. (author), Theelen, M. (author), Aydin, E. (author), Veenstra, S. (author), de Wolf, S. (author), Morales-Masis, M. (author)
Sputtered transparent conducting oxides (TCOs) are widely accepted transparent electrodes for several types of high-efficiency solar cells. However, the different sputtering yield of atoms makes stoichiometric transfer of target material challenging for multi-compounds. Additionally, the high kinetic energies of the arriving species may damage...
article 2021
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Pil, A. (author)
TNO en Demcon Focal helpen bij het ontwerp en de bouw van het totale laser guide star-projectiesysteem voor de Extremely Large Telescope.
article 2021
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Kerstholt, J. (author), van den Berg, H. (author), van Hemert, D. (author)
Om het coronavirus te bestrijden moeten overheid en burgers samenwerken. De overheid kondigt daarbij maatregelen af om het virus in te dammen. Maar de tijd is voorbij dat burgers maatregelen blindelings opvolgen. Interventies die gestoeld zijn op kennis over menselijk gedrag zijn beter dan handhaving om gewenst gedrag af te dwingen.
article 2021
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Meessen, R. (author), van Berlo, M. (author)
De coronacrisis maakt duidelijk dat hybride dreigingen niet meer weg te denken zijn uit onze samenleving. Ze manifesteren zich overal en in verschillende vormen, en zullen de komende tijd ook onder ons blijven. Alleen een weerbare samenleving kan deze dreigingen enigszins pareren.
article 2021
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Pot, F. (author), Totterdill, P. (author), Dhondt, S. (author)
Workplace innovation, as it developed from the beginning of this century in Europe, is a member of the Sociotechnical Systems Design (STSD) family (Mohr & Van Amelsvoort, 2016), going back to the restructuring of Europe after the Second World War, starting more or less the same policies for productivity and industrial democracy in several...
bookPart 2021
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Oeij, P.R.A. (author), Preenen, P.T.Y. (author), Dhondt, S. (author)
Redesigning organisations and work processes can lead to better organisational performance and jobs in general (e.g., Bloom & van Reenen, 2010; Boxall, 2012; Boxall & Macky, 2009). Workplace innovation (WPI), a specific approach focusing on participative organisational redesign, is beneficial for both business performance and the quality of jobs...
bookPart 2021
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Prabowo, B. (author), Zheng, G. (author), Mehrpoo, M. (author), Patra, B. (author), Harvey-Collard, P. (author), Dijkema, J. (author), Sammak, A. (author), Scappucci, G. (author), Charbon, E. (author), Sebastiano, F. (author), Vandersypen, L.M.K. (author), Babaie, M. (author)
Quantum computers (QC) promise to solve certain computational problems exponentially faster than a classical computer due to the superposition and entanglement properties of quantum bits (qubits). Among several qubit technologies, spin qubits are a promising candidate for large-scale QC, since (1) they have a small footprint allowing them to be...
conference paper 2021
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Gopaul, V.S. (author), Pieterman, E.J. (author), Princen, H.M.G. (author), Bergenholm, L. (author), Lundborg, E. (author), Cavallin, A. (author), Johansson, M.J. (author), Hawthorne, G. (author), Björkbom, A. (author), Hammarberg, M. (author), Li, X. (author), Jarke, A. (author), Bright, J. (author), Svensson, L. (author), Jansson-Löfmark, R. (author), Abrahamsson, B. (author), Agrawal, R. (author), 1 Hurt-Camejo, E. (author)
We investigated the effects of mineral oil on statin pharmacokinetics and inflammatory markers in animal models. A new synthesis strategy produced regioisomers that facilitated the characterization of the main metabolite (M1) of atorvastatin, a lipophilic statin, in C57BL/6NCrl mice. The chemical structure of M1 in mice was confirmed as ortho...
article 2021
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van Gemert, Y. (author), Kozijn, A.E. (author), Pouwer, M.G. (author), Kruisbergen, N.N.L. (author), van den Bosch, M.H.J. (author), Blom, A.B. (author), Pieterman, E.J. (author), Weinans, H. (author), Stoop, R. (author), Princen, H.M.G. (author), van Lent, P.L.E.M. (author)
Objective: High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a potential treatment for OA. We investigated whether therapeutic high-intensive cholesterol-lowering attenuated OA development in dyslipidemic APOE*3Leiden.CETP mice. Methods:...
article 2021
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Luo, X. (author), Grossbichler, M. (author), Waschl, H. (author), Donkers, M.C.F. (author), de Jager, B. (author), Willems, F.P.T. (author)
When controlled in an open-loop fashion, both stationary and dynamical diesel engine performance can deteriorate due to disturbances. Although cycle-to-cycle fuel injection control has the potential of reducing the performance degradation by manipulating the fueling profile in real time, this potential has not been thoroughly studied. This is...
article 2021
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Ros, J.A. (author), Doedée, V. (author), van den Akker, J.T. (author), Vredeveldt, A.W. (author), Linders, M.J.G. (author), Goetheer, E.L.V. (author), Garcia Moretz-Sohn Monteiro, J. (author)
The maritime industry has set clear objectives towards reducing greenhouse gas emissions in the coming decades. Ship based carbon capture (SBCC) could play a large role in reducing these emissions on the short term. This study gives an update on the work that has been conducted towards carbon capture and storage on LNG fuelled vessels. This is...
conference paper 2021
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Steen, M. (author), Sand, M. (author), van de Poel, I. (author)
Governments and companies are increasingly promoting and organizing Responsible Innovation. It is, however, unclear how the seemingly incompatible demands for responsibility, which is associated with care and caution, can be harmonized with demands for innovation, which is associated with risk-taking and speed. We turn to the tradition of virtue...
article 2021
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Steen, M. (author)
In this essay, the author reflects on several personal experiences in projects and advocates Slow Innovation as an alternative to the putative need for speed, the primacy of efficiency and the assumption that faster is better. Yes, RI does take time. Let us wear Slow Innovation as a badge of honour. Let us promote reflexivity: make time for...
article 2021
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Koodly Ravishankara, A. (author), Özdemir, H. (author), van der Weide, E. (author)
The surface of wind turbine blades are prone to degradation due to exposure to the elements. Rain, hail, insects are among the many causes of turbine blade degradation or erosion. Surface degradation of the wind turbine blades leads to a reduction in the aerodynamic performance, resulting in power losses. The effect of surface degradation is...
article 2021
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González Díez, N. (author), Belfroid, S.P.C. (author), Iversen Solfeldt, T. (author)
Flow-induced pulsations (FLIP) are pressure oscillations generated inside of flexibles used in dry gas applications that can cause unacceptable vibration levels and eventually failure of equipment. Because of the design of inner layer of the flexibles, the carcass, the frequency of the pulsations is high, potentially leading to fatigue failures...
conference paper 2021
Searched for: subject:"Innovation"
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