Safety evaluation of Protaminobacter rubrum: Intravenous pathogenicity and toxigenicity study in rabbits and mice

The iv pathogenicity and toxigenicity of Protaminobacter rubrum was studied in New Zealand White rabbits and CF1 BR mice. Following a probe study, nine groups of six rabbits each were injected iv with: 1 ml of viable-cell suspension (VCS) at concentrations of 2.23 x 108, 106, 104 and 102 organisms/ml; the cell-free supernatants (CFS; in which...

The binding of sarin in the blood plasma of the rat

Sephadex filtration of serum from rats 10 min after injection of 50 μg/kg of 32P-sarin demonstrated that about 70 per cent of the radioactivity present in the serum was attached to molecules with a molecular weight above 10,000. Incubation of samples of this serum with oximes caused a decrease in the amounts of 32P attached to the large...